Design, fabrication, and characterization of a scalable tissue-engineered-electronic-nerve-interface (TEENI) device

Desai, Vidhi H.; Spearman, Benjamin S.; Shafor, Chancellor S.; Natt, Sruthi; Teem, Brandon; Graham, James B.; Atkinson, Eric W.; Wachs, Rebecca A.; Nunamaker, Elizabeth A.; Otto, Kevin J.; Schmidt, Christine E.; Judy, Jack W.

doi:10.1109/ner.2017.8008326

Cited by 15 publications

(8 citation statements)

References 10 publications

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“…In addition, the extensive use of hydrogels and natural ECM components in the field of tissue engineering has found a natural application in regenerative nerve interfaces. Hybrid tissue-engineered electronic nerve interfaces (TEENIs) have been developed to promote nerve regrowth within a hydrogel-based scaffold, while guaranteeing high precision in stimulation and recording through microelectrodes patterned on PI threads [232].…”

Section: Soft Materials and Non-conventional Fabrication Strategiesmentioning

confidence: 99%

Compliant peripheral nerve interfaces

et al. 2021

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Peripheral nerve interfaces (PNIs) record and/or modulate neural activity of nerves, which are responsible for conducting sensory-motor information to and from the central nervous system, and for regulating the activity of inner organs. PNIs are used both in neuroscience research and in therapeutical applications such as precise closed-loop control of neuroprosthetic limbs, treatment of neuropathic pain and restoration of vital functions (e.g. breathing and bladder management). Implantable interfaces represent an attractive solution to directly access peripheral nerves and provide enhanced selectivity both in recording and in stimulation, compared to their non-invasive counterparts. Nevertheless, the long-term functionality of implantable PNIs is limited by tissue damage, which occurs at the implant-tissue interface, and is thus highly dependent on material properties, biocompatibility and implant design. Current research focuses on the development of mechanically compliant PNIs, which adapt to the anatomy and dynamic movements of nerves in the body thereby limiting foreign body response. In this paper, we review recent progress in the development of flexible and implantable PNIs, highlighting promising solutions related to materials selection and their associated fabrication methods, and integrated functions. We report on the variety of available interface designs (intraneural, extraneural and regenerative) and different modulation techniques (electrical, optical, chemical) emphasizing the main challenges associated with integrating such systems on compliant substrates.

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Section: Soft Materials and Non-conventional Fabrication Strategiesmentioning

confidence: 99%

Compliant peripheral nerve interfaces

et al. 2021

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“…This increased selectively can ultimately translate to improved prosthetic control ( Tyler and Durand, 2002 ; Ghafoor et al, 2017 ; Straka et al, 2018 ). The downside of such intimate contact is the potential for damage resulting from micro-motion ( Branner et al, 2004 ; Desai et al, 2017 ; Wurth et al, 2017 ). Additionally, the classification of sieve electrodes as most invasive is based on the neurorrhaphy model in which they are tested ( Navarro et al, 2005 ) and are not necessarily reflective of the amputation setting.…”

Section: Discussionmentioning

confidence: 99%

“…Sieve electrodes represent a type of PNI with the greatest potential for selectivity resulting from their well-spaced specificity within the nerve. These devices involve invasive nerve transection ( Navarro et al, 2005 ; MacEwan et al, 2016 ; Desai et al, 2017 ; Ghafoor et al, 2017 ), and rely on robust neural regeneration through electrode transit zones, assimilating the PNI into the nerve. In the amputation setting, it may be possible to simply interface the sieve array with the residual nerve end, taking advantage of the regenerative process that would otherwise lead to neuroma formation.…”

Section: Introductionmentioning

confidence: 99%

Improving the Selectivity of an Osseointegrated Neural Interface: Proof of Concept For Housing Sieve Electrode Arrays in the Medullary Canal of Long Bones

et al. 2021

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Sieve electrodes stand poised to deliver the selectivity required for driving advanced prosthetics but are considered inherently invasive and lack the stability required for a chronic solution. This proof of concept experiment investigates the potential for the housing and engagement of a sieve electrode within the medullary canal as part of an osseointegrated neural interface (ONI) for greater selectivity toward improving prosthetic control. The working hypotheses are that (A) the addition of a sieve interface to a cuff electrode housed within the medullary canal of the femur as part of an ONI would be capable of measuring efferent and afferent compound nerve action potentials (CNAPs) through a greater number of channels; (B) that signaling improves over time; and (C) that stimulation at this interface generates measurable cortical somatosensory evoked potentials through a greater number of channels. The modified ONI was tested in a rabbit (n = 1) amputation model over 12 weeks, comparing the sieve component to the cuff, and subsequently compared to historical data. Efferent CNAPs were successfully recorded from the sieve demonstrating physiological improvements in CNAPs between weeks 3 and 5, and somatosensory cortical responses recorded at 12 weeks postoperatively. This demonstrates that sieve electrodes can be housed and function within the medullary canal, demonstrated by improved nerve engagement and distinct cortical sensory feedback. This data presents the conceptual framework for housing more sophisticated sieve electrodes in bone as part of an ONI for improving selectivity with percutaneous connectivity toward improved prosthetic control.

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“…The multielectrode TEENI threads are supported by a triple-component hydrogel scaffold, which has mechanical properties designed to hold the TEENI threads in place while also reducing foreign-body response. The hydrogel is also designed to degrade gradually during nerve regeneration and to ultimately be replaced by regrown and maturing axons and vasculature [4].…”

Section: Designmentioning

confidence: 99%

Robust and Scalable Tissue-Engineerined Electronic Nerve Interfaces (Teeni)

Kuliasha¹,

Spearman²,

Atkinson³

et al. 2018

2018 Solid-State, Actuators, and Microsystems Workshop Technical Digest

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Peripheral nerves are excellent targets for neural interfaces designed to help amputees control prosthetic limbs. However, existing nerve interfaces have designs that significantly limit system performance. To overcome these limitations, we have combined micromachined neural interfaces with tissue-engineered hydrogel-based scaffolds. These tissue-engineered electronic nerve interfaces (TEENI) enable highly scalable nerve interfaces that provide significant interface-design freedom. The use of a hightemperature reactive-accelerated-aging (RAA) soak test sped the identification of a microfabrication processes that can yield robust nerve interfaces. Electrophysiological experiments demonstrate the high-SNR recording performance of chronically implanted TEENI devices.

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Design, fabrication, and characterization of a scalable tissue-engineered-electronic-nerve-interface (TEENI) device

Cited by 15 publications

References 10 publications

Compliant peripheral nerve interfaces

Compliant peripheral nerve interfaces

Improving the Selectivity of an Osseointegrated Neural Interface: Proof of Concept For Housing Sieve Electrode Arrays in the Medullary Canal of Long Bones

Robust and Scalable Tissue-Engineerined Electronic Nerve Interfaces (Teeni)

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