Design, characterization, teratogenicity testing, antibacterial, antifungal and DNA interaction of few high spin Fe(II) Schiff base amino acid complexes

Abdel‐Rahman, Laila H.; El‐Khatib, Rafat M.; Nassr, Lobna A. E.; Abu‐Dief, Ahmed M.; Lashin, Fakhr El-Din

doi:10.1016/j.saa.2013.03.061

Cited by 148 publications

(88 citation statements)

References 56 publications

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“…The (COO -) bands at 1541 cm -1 and 1390 cm -1 for asymmetric and symmetric stretching in ligands are shifted to 1496 cm -1 and 1311 cm -1 in complexes. A new band at 3404 cm -1 is ascertained in the spectra of complex only and is assigned to υ(H 2 O) [8,10,12].…”

Section: Infrared Studiesmentioning

confidence: 99%

“…Amino acids have importance in Schiff base complexes formation in which these can act as ligands due to their physiological and pharmacological activities. Moreover, these metal chelates appear to be involved in many of biological processes, such as transamination, racemization and carboxylation [10]. In particular histidine is a very important bioactive amino acid.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of Schiff bases derived from 2-hydroxy-1- naphth- aldehyde and their tin(II) complexes for antimicribial and antioxidant activities

Neelofar¹,

Ali²,

Khan³

et al. 2018

Bull. Chem. Soc. Eth.

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ABSTRACT.The current studies were designed to prepare tin(II) complexes of various Schiff base derivatives of 2-hydroxy-1-naphthaldehyde (HN) with L-histidine and sulfamethazine have been prepared and characterized by different physiochemical studies such as elemental analysis, atomic absorption, UV-Vis spectra, FTIR spectra, 1 H-NMR, 13 C-NMR and conductance studies. Antimicrobial and antioxidant activities were also calculated. Antibacterial activity was evaluated by the agar-well diffusion method. Two Gram-negative (Klebsiella pneumoniae and Escherichia coli) and three Gram-positive (Staphylococcus aureus, Staphylococcus epidermidis and Bacillus subtilis) bacterial strains were used. Antifungal activity was resolute against three fungal strains (Aspergillus niger, Aspergillus flavus and Alternaria solani) by using the agar tube dilution method. The antioxidant activity of ligands and their complexes was measured on the basis of the radical scavenging effect of 1,1-diphenyl-2-picryl-hydrazyl (DPPH)-free radical activity. Ligand HNSM exhibited excellent activities as antibacterial activity (22 mm), antifungal activity (55%) and antioxidant activity (119 ppm).

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Section: Infrared Studiesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Synthesis of Schiff bases derived from 2-hydroxy-1- naphth- aldehyde and their tin(II) complexes for antimicribial and antioxidant activities

Neelofar¹,

Ali²,

Khan³

et al. 2018

Bull. Chem. Soc. Eth.

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show abstract

“…Typical vibrational bands of the Schiff bases, 3-hmp, 4-hmp and hmyp, related to the stretching mode of the hydroxyl and the imine bond were in the region of 3280 and 1621 cm -1 , respectively [9][10][11]. Upon coordination, the vibrational band of the imine bond shifted almost 10 cm -1 towards low frequency in complex-1 and 2 and 28 cm -1 towards high frequency in complex-3.…”

Section: Infrared Spectroscopymentioning

confidence: 99%

Synthesis, Characterisation and Antimicrobial Activity of Dimeric and Monomeric Copper(II)-Schiff base Complexes

Santos¹,

Oliveira²,

Maia³

2017

IOSR JAC

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“…Transition metal ions are essential for the normal functioning of living organisms. Therefore, it is not surprising that transition metal complexes are of great interest as effective drugs and these complexes with tunable coordination environments and versatile spectral and electrochemical properties offer a great scope for design of new species that are suitable for DNA interactions [9][10][11]. The literature survey revealed that more attention has been given to Schiff base complexes derived by using 4-aminoantipyrine as a basic fundamental moiety.…”

Section: Introductionmentioning

confidence: 99%

Biological Screening Studies of DNA Relate Metal Complexes from Benzylidene-4-imino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one and 2-aminothiazole

Palanimurugan¹,

Kulandaisamy²

2018

Asian J. Chem.

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Novel terdentate cationic complexes of Cu(II), Ni(II), Co(II), Mn(II) and Zn(II) ion have been prepared using a Schiff base derived from benzylidene-4-imino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one and 2-aminothiazole. The structural features of metal-chelates have been confirmed by micro-analytical data, FAB-Mass spectra, powder XRD, SEM, FTIR, UV-visible, 1 H NMR, EPR, CV and thermal analysis techniques. The analytical data of the complexes correspond well with the general formula [ML2]Cl2. The high conductance data of metal chelates supports their 1:2 electrolytic nature. The magnetic susceptibility and electronic absorption spectra of the complexes indicate that all the metal-chelates exhibit octahedral geometry around the central metal ion. Powder XRD data and SEM images persist that the complexes are nano size grain with polycrystalline structure. DNA interaction studies of [CuL2]Cl2 complex have been done by electronic spectral and cyclic voltammetric measurements which revealed that the binding occurs through intercalation between complex and DNA interaction of [CuL2]Cl2 complex with CT-DNA leads to hypochromism. The MIC values against the growth of microorganisms are lower for metal chelates than the ligand. This is mainly due to lipophilicity of metal ion in complexes.

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Design, characterization, teratogenicity testing, antibacterial, antifungal and DNA interaction of few high spin Fe(II) Schiff base amino acid complexes

Cited by 148 publications

References 56 publications

Synthesis of Schiff bases derived from 2-hydroxy-1- naphth- aldehyde and their tin(II) complexes for antimicribial and antioxidant activities

Synthesis of Schiff bases derived from 2-hydroxy-1- naphth- aldehyde and their tin(II) complexes for antimicribial and antioxidant activities

Synthesis, Characterisation and Antimicrobial Activity of Dimeric and Monomeric Copper(II)-Schiff base Complexes

Biological Screening Studies of DNA Relate Metal Complexes from Benzylidene-4-imino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one and 2-aminothiazole

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