Design and synthesis of polymeric membranes using water-soluble pore formers: an overview

Malik, Tabassum; Razzaq, Humaira; Razzaque, Shumaila; Nawaz, Hifza; Siddiqa, Asima; Siddiq, Muhammad; Qaisar, Sara

doi:10.1007/s00289-018-2616-3

Cited by 39 publications

(24 citation statements)

References 143 publications

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“…2 d, emulsions with PVP/VA in the oil phase and lecithin and maltose in the water phase, with the formation of microneedles with interconnected pores, evenly distributed throughout the length of the cone. Different types of PVP are reported to be able to produce high-porosity structures, such as cross-linked PVP, homopolymers (with different molecular weights) or copolymers (Malik et al 2019 ). Likewise, an enhancement of porosity into biomedical formulations has been reported using PVP as additive (Franco and De Marco 2020 ).…”

Section: Resultsmentioning

confidence: 99%

Engineered PLGA-PVP/VA based formulations to produce electro-drawn fast biodegradable microneedles for labile biomolecule delivery

et al. 2020

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Biodegradable polymer microneedles (MNs) are recognized as non-toxic, safe and stable systems for advanced drug delivery and cutaneous treatments, allowing a direct intradermal delivery and in some cases a controlled release. Most of the microneedles found in the literature are fabricated by micromolding, which is a multistep thus typically costly process. Due to industrial needs, mold-free methods represent a very intriguing approach in microneedle fabrication. Electro-drawing (ED) has been recently proposed as an alternative fast, mild temperature and one-step strategy to the mold-based techniques for the fabrication of poly(lactic-co-glycolic acid) (PLGA) biodegradable MNs. In this work, taking advantage of the flexibility of the ED technology, we engineered microneedle inner microstructure by acting on the water-in-oil (W/O) precursor emulsion formulation to tune drug release profile. Particularly, to promote a faster release of the active pharmaceutical ingredient, we substituted part of PLGA with poly(1-vinylpyrrolidone-co-vinyl acetate) (PVP/VA), as compared to the PLGA alone in the matrix material. Moreover, we introduced lecithin and maltose as emulsion stabilizers. Microneedle inner structural analysis as well as collagenase entrapment efficiency, release and activity of different emulsion formulations were compared to reach an interconnected porosity MN structure, aimed at providing an efficient protein release profile. Furthermore, MN mechanical properties were examined as well as its ability to pierce the stratum corneum on a pig skin model, while the drug diffusion from the MN body was monitored in an in vitro collagen-based dermal model at selected time points.

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Section: Resultsmentioning

confidence: 99%

Engineered PLGA-PVP/VA based formulations to produce electro-drawn fast biodegradable microneedles for labile biomolecule delivery

et al. 2020

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“…[ 34 , 35 , 36 , 37 , 38 , 39 ] and water-soluble polymers (WSPs) (e.g., polyvinyl pyrrolidone (PVP), polyethylene glycol (PEG), etc.) [ 40 , 41 , 42 ]. Since small molecule additives have limitations in controlling over the pore structure of film, WSPs having the potential to tune the pore morphology due to their greater incompatibility with the substrate are an ideal candidate for porous film production.…”

Section: Introductionmentioning

confidence: 99%

Porous Film Coating Enabled by Polyvinyl Pyrrolidone (PVP) for Enhanced Air Permeability of Fabrics: The Effect of PVP Molecule Weight and Dosage

Jiang

Shen

et al. 2020

Polymers

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This study developed a versatile and facile method for creating pores and tuning the porous structure in the polymer latex films by selectively etching the added functional polyvinyl pyrrolidone (PVP) molecules. The pore formed in the latex films had a similar morphology to that of PVP aggregation before etching. This observation promotes us to regulate the pore morphology that determines the film’s property, such as air permeability through varying the PVP molecule weight and dosage. To this end, the effects of PVP molecule weight and dosage on the pore formation were systematically studied. The results showed that the average pore size of porous film decreased from >10 μm to sub-micron (about 0.4 μm) as the molecular weight or the dosage of PVP increased. This was ascribed to the strong adsorption affinity of PVP molecule onto the latex particle surface, which further hindered the diffusion and self-assembly of PVP molecule. In addition, this interaction became much stronger when the higher molecule weight of PVP or the higher dosage of PVP was employed, leading to the decreased size of PVP aggregation, as well as the formed pores in the latex films. Furthermore, the addition of PVP had little effect on the color of coated fabric based on the results of CIE L*a*b* measurement. The proposed facile method can be used to improve the air permeability of coated fabrics.

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“…Moreover, using pore precursors such aspoly(vinyl pyrrolidone) or poly(ethylene glycol) can improve the hydrophilicity and mechanical properties of membranes. This is important due to the hydrophobic nature of most synthetic polymers used for scaffold manufacturing [ 67 , 75 ]…”

Section: Scaffold For Articular Cartilage Repair: Requirements Mamentioning

confidence: 99%

Review of Synthetic and Hybrid Scaffolds in Cartilage Tissue Engineering

2020

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Cartilage tissue is under extensive investigation in tissue engineering and regenerative medicine studies because of its limited regenerative potential. Currently, many scaffolds are undergoing scientific and clinical research. A key for appropriate scaffolding is the assurance of a temporary cellular environment that allows the cells to function as in native tissue. These scaffolds should meet the relevant requirements, including appropriate architecture and physicochemical and biological properties. This is necessary for proper cell growth, which is associated with the adequate regeneration of cartilage. This paper presents a review of the development of scaffolds from synthetic polymers and hybrid materials employed for the engineering of cartilage tissue and regenerative medicine. Initially, general information on articular cartilage and an overview of the clinical strategies for the treatment of cartilage defects are presented. Then, the requirements for scaffolds in regenerative medicine, materials intended for membranes, and methods for obtaining them are briefly described. We also describe the hybrid materials that combine the advantages of both synthetic and natural polymers, which provide better properties for the scaffold. The last part of the article is focused on scaffolds in cartilage tissue engineering that have been confirmed by undergoing preclinical and clinical tests.

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Design and synthesis of polymeric membranes using water-soluble pore formers: an overview

Cited by 39 publications

References 143 publications

Engineered PLGA-PVP/VA based formulations to produce electro-drawn fast biodegradable microneedles for labile biomolecule delivery

Engineered PLGA-PVP/VA based formulations to produce electro-drawn fast biodegradable microneedles for labile biomolecule delivery

Porous Film Coating Enabled by Polyvinyl Pyrrolidone (PVP) for Enhanced Air Permeability of Fabrics: The Effect of PVP Molecule Weight and Dosage

Review of Synthetic and Hybrid Scaffolds in Cartilage Tissue Engineering

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