Design and Synthesis of New Porphyrin Analogues as Potent Photosensitizers for Photodynamic Therapy: Spectroscopic Approach

Nonionic omnisoluble photosensitizer reference material for the estimation of singlet oxygen quantum yield

“…Studies of 1 O 2 photosensitization using organic chromophores are usually conducted in the solution state with estimations of Φ SO based on comparison with a known reference standard material such as RB, 12,31 PN derivatives 14,32 or tetraphenylporphyrin (TPP) derivatives. 15–19,33 TPP derivatives are well known 1 O 2 photosensitizers and their related properties and mechanisms of action have been well known for decades. 34,35 Selection of a material as reference is dictated partly by the solubility of the prospective reference in the required solvent(s) and its absorption spectrum in those solvents (it should have a significant absorbance at the required excitation wavelength for normalization).…”

An Anti‐inflammatory Fe3O4‐Porphyrin Nanohybrid Capable of Apoptosis through Upregulation of p21 Kinase Inhibitor Having Immunoprotective Properties under Anticancer PDT Conditions

“…The efficient generation of singlet oxygen by the target PSs was determined through photooxidation of 9,10-dimethylanthracene (DMA) [36][37][38] using H 2 TPP (Φ Δ = 0.64 in DMF) as a standard. [37] The details of the experiment performed are given below. Compared to the reference H 2 TPP, the quantum yield of singlet oxygen generation for E-NP was 0.78 (Table S2).…”

“…The dark stability of any PS and its ability to resist degradation post-exposure to radiation is a marker of its photostability. [36][37][38] It was observed that the absorption spectra recorded before running each set of photophysical and photobiological experiments with the same solution did not show any variation in spectral data. To further assess the photostability of the freebase porphyrins and the corresponding Fe 3 O 4 -porphyrin nanohybrids, 10 μM aqueous solution of compounds E and E-NP were prepared.…”

“…The efficient generation of singlet oxygen by the target PSs was determined through photooxidation of 9,10-dimethylanmthracene (DMA). [36][37][38] Time-dependent decrease in absorbance of DMA at 402 nm was monitored separately in presence of E and E-NP. DMA reacts with singlet oxygen generated by the PSs forming endoperoxide.…”

Simple Nonionic Omnisoluble Tetraphenylporphyrin for Relative Referencing of Singlet Oxygen Quantum Yield

“…Studies of 1 O2 photosensitization using organic chromophores are usually conducted in the solution state with estimations of ΦSO based on comparison with a known reference standard material such as RB, 12,29 PN derivatives 14,30 or tetraphenylporphyrin derivatives. [15][16][17][18][19]31 Selection of a material as reference is dictated by the solubility of the prospective reference in the required solvent(s) and its absorption spectrum in those solvents (it should have a significant absorbance at the required excitation wavelength for normalization). TEG12PH2 is a tetraphenylporphyrin (TPPH2) derivative exhibiting sufficient solubility/miscibility (it is a liquid at r.t.p.)…”