Design and Synthesis of Benzodiazepines Bearing Benzimidazole/Benzothiazole and Indole Moieties as a Potent Antimicrobial and Antioxidant Agents

Abstract

Objective: The present work deals with the synthesis and characterization of biologically active new indole derivatives, namely, 2-Methods: All these newly synthesized compounds were screened for their in vitro antimicrobial activity by an agar plate diffusion method, antioxidant activities such as 1,1-diphenyl-2-picrylhydrazyl (DPPH), radical scavenging activity (RSA), ferric ions (Fe Result:The structures of all the newly synthesized compounds were characterized by their infrared, 1 H nuclear magnetic resonance, mass spectral studies, and elemental analysis. Compounds 7a and 7b exhibited good RSA at a concentration 100 µg/ml, compounds 6d, 7a-d and 8a-c displayed good FRAP at a concentration 100 µg/ml, compounds 7b-d and 8b-d showed good Fe 2+ ion metal chelating activity. Compounds 6b, 6d, 7a-d, and 8a-d exhibited good activity against all the screened bacteria and fungi.Conclusion: Some of the compounds have shown potent antimicrobial activity against all the screened bacteria and fungi, and some have exhibited very good antioxidant activity.

Green synthesis of pyrazolines as anti-inflammatory, antimicrobial and antioxidant agents

“…% Haemolysis = 100-absorbance of sample /absorbance of control ×100 3.3 Antimicrobial activity: All the synthesized compounds were screened for their antibacterial activities against Staphylococcus aureus and Escherichia coli using a modi ed agar diffusion assay method Streptomycin was used as the positive control. Incubation temperature and period for antibacterial activity was at 37 for 24 hrs Results of antimicrobial activities are expressed in terms of zone of inhibition [19]. The result of activity of the synthesized compounds is shown in table 3.…”