Design and Development of Neomycin Sulfate Gel Loaded with Solid Lipid Nanoparticles for Buccal Mucosal Wound Healing

Hosny, Khaled M.; Naveen, N. Raghavendra; Kurakula, Mallesh; Sindi, Amal M.; Sabei, Fahad Y.; Fatease, Adel Al; Jali, Abdulmajeed M.; Alharbi, Waleed S.; Mushtaq, Rayan Y.; Felemban, Majed; Tayeb, Hossam H.; Alfayez, Eman; Rizg, Waleed Y.

doi:10.3390/gels8060385

Cited by 24 publications

(12 citation statements)

References 46 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This evaluation is done by identifying and studying the interaction between independent and dependent variables and how they affect product performance; an approach that results in fewer experiments that are time-and cost-efficient. The main elements of QbD are defining desired product profiles, designing product and manufacturing processes, and identifying critical quality parameters and variables [35][36][37][38][39][40]. For developing mucoadhesive gels containing MIC, a D-optimal design with three variables was used.…”

Section: Introductionmentioning

confidence: 99%

Structural Characterization and Optimization of a Miconazole Oral Gel

Pintea

Vlad²,

Antonoaea³

et al. 2022

Polymers

View full text Add to dashboard Cite

The development of semisolid formulations, gels in particular, has raised the attention of scientists more and more over the last decades. Because of their biocompatibility, hydrophilic nature, and capacity of absorbing large quantities of water, hydrogels are still one of the most promising pharmaceutical formulations in the pharmaceutical industry. The purpose of this study is to develop an optimal formulation capable of incorporating a water-poorly soluble active ingredient such as miconazole used in the treatment of fungal infections with Candida albicans and Candida parapsilosis. A D-optimal design was applied to study the relationship between the formulation parameter and the gel characteristics. The independent parameters used in this study were the Carbopol 940 concentration (the polymer used to obtain the gel matrix), the sodium hydroxide amount, and the presence/absence of miconazole. Ten different dependent parameters (Y1–Y10) were evaluated (penetrometry, spreadability, viscosity, and tangential tension at 1 and 11 levels of speed whilst destructuring and during the reorganization of the gel matrix). The consistency of the gels ranged from 23.2 mm (GO2) to 29.6 mm (GM5). The least spreadable gel was GO7 (1384 mm2), whilst the gel that presented the best spreadability was GO1 (3525 mm2). The viscosity and the tangential stress at the selected levels (1 and 11) varied due to the different compositions of the proposed gels. The gels were also tested for drug content and antifungal activity. All determinations had satisfying results; the drug content was within limits accepted by Ph. Eur. 10 and all formulations containing miconazole exhibited antifungal activity. An optimal formulation with miconazole was attained, consisting of 0.84% Carbopol 940 and 0.32% sodium hydroxide.

show abstract

Section: Introductionmentioning

confidence: 99%

Structural Characterization and Optimization of a Miconazole Oral Gel

Pintea

Vlad²,

Antonoaea³

et al. 2022

Polymers

View full text Add to dashboard Cite

show abstract

“…The bands at 1119 and 1521 cm −1 were moving toward lower wavenumbers. Also, compared to the NS curve, the strength of the bands at 2927 and 1628 cm −1 (which have to do with the bending vibration of OH groups) was lower (Hosny et al., 2022 ). The bending vibrations of CeH groups in phenyl rings caused the peak to show up at 857 cm −1 .…”

Section: Resultsmentioning

confidence: 99%

Optimization of process parameters for fabrication of electrospun nanofibers containing neomycin sulfate and Malva sylvestris extract for a better diabetic wound healing

Islam

Ramesh²,

Bhavani³

et al. 2022

Drug Delivery

Self Cite

View full text Add to dashboard Cite

Diabetes mellitus is one of the most concerning conditions, and its chronic consequences are almost always accompanied by infection, oxidative stress, and inflammation. Reducing excessive reactive oxygen species and the wound’s inflammatory response is a necessary treatment during the acute inflammatory phase of diabetic wound healing. Malva sylvestris extract (MS) containing nanofibers containing neomycin sulfate (NS) were synthesized for this investigation, and their impact on the healing process of diabetic wounds was assessed. Using Design Expert, the electrospinning process for the fabrication of NS nanofibers (NS-NF) was adjusted for applied voltage ( X 1 ), the distance between the needle’s tip and the collector ( X 2 ), and the feed rate ( X 3 ) for attaining desired entrapment efficacy [EE] and average nanofiber diameter (ND). The optimal formulation can be prepared with 19.11 kV of voltage, 20 cm of distance, and a flow rate of 0.502 mL/h utilizing the desirability approach. All the selected parameters and responses have their impact on drug delivery from nanofibers. In addition, M. sylvestris extracts have been added into the optimal formulation [MS-NS-NF] and assessed for their surface morphology, tensile strength, water absorption potential, and in vitro drug release studies. The NS and MS delivery from MS-NS-NF has been extended for more than 60 h. M. sylvestris -loaded nanofibers demonstrated superior antibacterial activity compared to plain NS nanofibers. The scaffolds featured a broad aspect and a highly linked porous fibrous network structure. Histomorphometry study and the in vitro scratch assay demonstrate the formulation’s efficacy in treating diabetic wound healing. The cells treated with MS-NS-NF in vivo demonstrated that wound dressings successfully reduced both acute and chronic inflammations. To improve the healing of diabetic wounds, MS-NS-NF may be regarded as an appropriate candidate for wound dressing.

show abstract

“…This novel formulation also promoted neomycin bioavailability because of successful mucosal membrane permeation. Furthermore, it could preserve its efficacious properties after one month of storage at 25 °C, enhancing its effect on wound healing [ 54 ]. Simvastatin (SIM), an HMG-Co reductase inhibitor known for its cholesterol-lowering effect, had been encapsulated in self-gelling SLNs to evaluate its wound-repairing activity.…”

Section: Mechanism Of Lipid-based Drug Delivery Systemsmentioning

confidence: 99%

Combinational System of Lipid-Based Nanocarriers and Biodegradable Polymers for Wound Healing: An Updated Review

Far

Naimi-Jamal

Sedaghat

et al. 2023

JFB

View full text Add to dashboard Cite

Skin wounds have imposed serious socioeconomic burdens on healthcare providers and patients. There are just more than 25,000 burn injury-related deaths reported each year. Conventional treatments do not often allow the re-establishment of the function of affected regions and structures, resulting in dehydration and wound infections. Many nanocarriers, such as lipid-based systems or biobased and biodegradable polymers and their associated platforms, are favorable in wound healing due to their ability to promote cell adhesion and migration, thus improving wound healing and reducing scarring. Hence, many researchers have focused on developing new wound dressings based on such compounds with desirable effects. However, when applied in wound healing, some problems occur, such as the high cost of public health, novel treatments emphasizing reduced healthcare costs, and increasing quality of treatment outcomes. The integrated hybrid systems of lipid-based nanocarriers (LNCs) and polymer-based systems can be promising as the solution for the above problems in the wound healing process. Furthermore, novel drug delivery systems showed more effective release of therapeutic agents, suitable mimicking of the physiological environment, and improvement in the function of the single system. This review highlights recent advances in lipid-based systems and the role of lipid-based carriers and biodegradable polymers in wound healing.

show abstract

Design and Development of Neomycin Sulfate Gel Loaded with Solid Lipid Nanoparticles for Buccal Mucosal Wound Healing

Cited by 24 publications

References 46 publications

Structural Characterization and Optimization of a Miconazole Oral Gel

Structural Characterization and Optimization of a Miconazole Oral Gel

Optimization of process parameters for fabrication of electrospun nanofibers containing neomycin sulfate and Malva sylvestris extract for a better diabetic wound healing

Combinational System of Lipid-Based Nanocarriers and Biodegradable Polymers for Wound Healing: An Updated Review

Contact Info

Product

Resources

About