Design and bioevaluation of a 32P-patch for brachytherapy of skin diseases

A Facile, Viable Approach Toward the Preparation of 32P Patches for the Treatment of Skin Cancer

“…Salgueiro et al have reported the procedure for preparation of 32 P sources for treatment of skin diseases. 10 However, their procedure needs multistage processing and makes the source preparation time consuming. They have also shown significant radioactivity leakage from their patches over a period of time.…”

“…In recent years, specially designed patches containing 32 P have been developed for contact brachytherapy of skin lesions. [8][9][10][11] In a previous work, the authors of the present study have reported the preliminary results on the preparation of 32 P-based skin patch to test the efficacy of 32 P in controlling tumor growth. 12 In this communication, a detailed investigation on the preparation, properties, and quality of 32 P-based skin patch has been evaluated.…”

Radioactive treatment of a murine melanoma using a 32P-patch

“…Our group, in particular, has been working on the preparation of a 32 P-patch, as this is the b-emitter available in our country, which showed promising results in the treatment of an NMSC animal model using Sencar mice [21,22]. This study describes our research work on the therapeutic effect of a 32 P-patch in a murine melanoma.…”

“…The activity concentration of patches was measured as described earlier [21,22]. Briefly, a sample of the patches was dissolved with hyamine hydroxide (MP Biomedicals, LLC, Ohio, USA) at room temperature overnight, and an aliquot was added to a vial containing 3 ml of a complete phase-combining system for liquid scintillation-counting (PCS; Amersham Biosciences, Piscataway, New Jersey, USA).…”

“…The patches were prepared as described earlier [21,22]. Briefly, we used chromic 32 P-phosphate (30-70 nm) and silicone (Silastic J-White 80, Dow Corning, The Dow Chemical Company and Corning Inc., Michigan, USA).…”