A Facile, Viable Approach Toward the Preparation of ³²P Patches for the Treatment of Skin Cancer

Abstract

A facile, viable, "green" two-step, inexpensive technique was developed for the preparation of (32)P patch for the treatment of skin cancer. This technique consists of impregnation of H(3)(32)PO(4) solution into an inert solid carrier followed by immobilization into a nonleachable matrix by lamination. The morphology of the impregnated paper was evaluated by scanning electron microscope and energy-dispersive spectral analyses. Radioactive patches containing up to ∼37 MBq/cm(2) of (32)P could be prepared. Distribution of (32)P on sources was uniform and release of (32)P from the sealed source in water and saline was found to be well within the permissible levels of 185 Bq. Custom-shaped (32)P-patches after quality assurance were supplied to AIIMS, New Delhi, for clinical evaluation. (32)P-impregnated paper protected by a laminated film holds promise for treatment of superficial cancers.

Comparison of the Effectiveness of Phosphorus 32 Application and 10 Mg/Cc Triamcinolone Acetonide Intralesional Injection on Keloid

“…7,10 This is easy to use, noninvasive, painless, as well as convenient for the patients. 11,12 This application can cause mild side effects, such as hypopigmentation, edema, erosion, erythema, ulceration, dermatitis, and hyperpigmentation. However, these side effects commonly subside spontaneously in two weeks.…”

“…Although the difference is not statistically significant, the 32 P application is shown to be easy to use, noninvasive, painless, and convenient for the patients. 11,12 …”

Determination of surface dose rate of indigenous 32 P patch brachytherapy source by experimental and Monte Carlo methods

“…Well established therapeutic efficacy, established calibration procedures, fixed radionuclidic properties, high specific activity and miniature size of sources are some of the additional advantages of radioactive patch brachytherapy over emerging electronic brachytherapy. Considering these advantages of patch brachytherapy over electronic brachytherapy and to fulfill the national requirements of treating the superficial lesions, 32 P patch sources were designed and fabricated indigenously at the Isotope Production and Application Division (IP&AD) of Bhabha Atomic Research Centre (Saxena et al, 2011(Saxena et al, , 2012.…”

An electrochemical pathway to prepare circular planar 90Sr/90Y sources for the calibration of surface contamination monitors

“…In pursuit of a pragmatic approach to undertake routine preparation of circular planar 90 Sr/ 90 Y source for the above application, various radioactive source preparation strategies explored in our laboratory [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] were scrupulously evaluated. Among the various options exploited, the scope of using electrodeposition technique is enticing from the viewpoints of technical simplicity, scalability, rapidity and reproducibility [4][5][6][7][8][9][10][11].…”