Radioactive treatment of a murine melanoma using a 32P-patch

Salgueiro, M.; Collia, N.; Barreiro, María L. Arcos; Medina, Vanina Araceli; Nicolini, J.O.; Cremaschi, Graciela; Zubillaga, Marcela

doi:10.1097/mnm.0b013e32832b9aad

Cited by 9 publications

(2 citation statements)

References 23 publications

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“…In recent years, specially designed patches containing 32 P have been developed for contact brachytherapy of skin lesions. [8][9][10][11] In a previous work, the authors of the present study have reported the preliminary results on the preparation of 32 P-based skin patch to test the efficacy of 32 P in controlling tumor growth. 12 In this communication, a detailed investigation on the preparation, properties, and quality of 32 P-based skin patch has been evaluated.…”

Section: Introductionmentioning

confidence: 99%

A Facile, Viable Approach Toward the Preparation of ³²P Patches for the Treatment of Skin Cancer

Saxena

Kumar

Pandey

et al. 2011

Cancer Biotherapy and Radiopharmaceuticals

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A facile, viable, "green" two-step, inexpensive technique was developed for the preparation of (32)P patch for the treatment of skin cancer. This technique consists of impregnation of H(3)(32)PO(4) solution into an inert solid carrier followed by immobilization into a nonleachable matrix by lamination. The morphology of the impregnated paper was evaluated by scanning electron microscope and energy-dispersive spectral analyses. Radioactive patches containing up to ∼37 MBq/cm(2) of (32)P could be prepared. Distribution of (32)P on sources was uniform and release of (32)P from the sealed source in water and saline was found to be well within the permissible levels of 185 Bq. Custom-shaped (32)P-patches after quality assurance were supplied to AIIMS, New Delhi, for clinical evaluation. (32)P-impregnated paper protected by a laminated film holds promise for treatment of superficial cancers.

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Section: Introductionmentioning

confidence: 99%

A Facile, Viable Approach Toward the Preparation of ³²P Patches for the Treatment of Skin Cancer

Saxena

Kumar

Pandey

et al. 2011

Cancer Biotherapy and Radiopharmaceuticals

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“…Combination therapies include surgery and radiotherapy are considered the best therapy for keloids that do not respond to conventional therapy 3 . Salgueiro (2009) has conducted research to see whether the effects of radioisotopes as open sources can have the same effect as a sealed source 4 . In this study, 32 P solution was converted into chromic phosphate powder which was then mixed with silicon to form 32 P sheets or plaster.…”

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confidence: 99%

Preliminary Study on Production Of 32P – Labeled Phosphate Chromic as A Material for Skin Patch

Rahman¹,

Sarmini²,

Herlina³

et al. 2019

IJPST

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Keloids are skin disorders or benign tumours that are due to abnormal wound healing in the binding tissue after trauma, inflammation, surgical wounds, or burns. Low activity radioisotopes have shown to be effective in curing or eliminating keloids on the skin. One of these radioisotopes is phosphorus-32 (32 P), a beta (β-) emitter with a half-life of 14.3 days. This radioisotope can also be developed for the treatment of keloid and skin tumours. Currently, the keloid is treated by conventional methods where a filter paper which has been wetted with 32 P in form of its sodium phosphate directly applied on the area of the keloid. However, this method is considered inefficient and less secure. The purpose of this research is to obtain technology for preparing of 32 P-labeled skin patch which is expected to be which will not decompose easily. The first step of this research is to produce 32 P-labeled chromic phosphate (Cr 32 PO 4) colloids, a precursor of skin patch, through condensation which involves oxidation-reduction reaction. In this step, Cr (VI) is reduced to Cr (III) to form Cr 32 PO 4 with a particle size of <1 μm. These particles (Cr 32 PO 4) are expected to evenly distributed when mixed with silicon to form skin patch. The reaction gave a yield of 97,8%. The results of characterization show that the prepared Cr 32 PO 4 colloids have a particle size of > 1μm. Further study needs to be performed in due time in order to have Cr 32 PO 4 colloids with suitable particle size.

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Radionuclide Therapy for Skin Malignancies

Cho

Lee

2012

Therapeutic Nuclear Medicine

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Radioactive treatment of a murine melanoma using a 32P-patch

Cited by 9 publications

References 23 publications

A Facile, Viable Approach Toward the Preparation of ³²P Patches for the Treatment of Skin Cancer

A Facile, Viable Approach Toward the Preparation of ³²P Patches for the Treatment of Skin Cancer

Preliminary Study on Production Of 32P – Labeled Phosphate Chromic as A Material for Skin Patch

Radionuclide Therapy for Skin Malignancies

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Radioactive treatment of a murine melanoma using a 32P-patch

Cited by 9 publications

References 23 publications

A Facile, Viable Approach Toward the Preparation of 32P Patches for the Treatment of Skin Cancer

A Facile, Viable Approach Toward the Preparation of 32P Patches for the Treatment of Skin Cancer

Preliminary Study on Production Of 32P – Labeled Phosphate Chromic as A Material for Skin Patch

Radionuclide Therapy for Skin Malignancies

Contact Info

Product

Resources

About

A Facile, Viable Approach Toward the Preparation of ³²P Patches for the Treatment of Skin Cancer

A Facile, Viable Approach Toward the Preparation of ³²P Patches for the Treatment of Skin Cancer