Descriptive case series of patients presenting with cancer of the prostate and their management at Kenyatta National Hospital, Nairobi

Wasike, Ronald; Magoha, G. A. O.

doi:10.4314/eamj.v84i9.9559

Cited by 14 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The means ages of Ogonis and Ijaw patients fell to the lower limits of these observations in Nigerians. The low mean and average ages of these patients agree with findings of mean age of prostate cancer patients of 61 years (peak of 66–70 years) observed by Wasike et al [ 19 ] in Nairobi Kenya. Factors that might have contributed to the lower average ages at the presentation of Ijaws and Ogonis include small sample sizes of patient population from these ethnic groups.…”

Section: Discussionsupporting

confidence: 90%

Ethnicity and prostate cancer in Southern Nigeria: A preliminary report

2015

View full text Add to dashboard Cite

Introduction:The natural history of prostate cancer varies among patients. The aim of this study is to detect any variations in clinical and pathological characteristics of the tumor in patients from different ethnic groups in Southern Nigeria.Patients and Methods:Consecutive patients who presented with features of prostatic diseases at the Urology Units of University of Port Harcourt Teaching Hospital, Port Harcourt and Nnamdi Azikiwe University Teaching Hospital, Nnewi, were evaluated prospectively with history, physical examination, and relevant investigations using a proforma. Data obtained were collated and analyzed statistically using the Chi-square test and Microsoft Excel.Results:Of 187 patients studied, 169 were analyzed. Eighty-six were Ibos, 31 Ijaws, 25 Ikwerres, and 12 Ogonis. Two were from each Etche, Urhobo, Opobo, and Effik; 4 from Andoni, and 3 Ibibio. Fifty-seven (66.3%) Ibos presented with the disease at higher ages (70–80 years) than 19 (61.3%) Ijaws and 11 (91.7%) Ogonis. These age differences were statistically significant with 95% and 99.9% confidence, respectively. All cases were adenocarcinomas. Clinical features, pattern of serum prostate-specific antigen levels, grades of the tumors, tumor metastases, and complications were similar for all ethnic groups. Although more Ibos had tumors with relatively more aggressive metastatic features, there was no statistical significance.Conclusion:Clinical and pathological features of adenocarcinoma of the prostate in Ibos, Ikwerres, Ijaws, and Ogonis were found to be similar. However, Ibos presented with the disease at older ages than Ijaws and Ogonis.

show abstract

Section: Discussionsupporting

confidence: 90%

Ethnicity and prostate cancer in Southern Nigeria: A preliminary report

2015

View full text Add to dashboard Cite

show abstract

“…Prostate cancer treatment is contingent to the clinical presentation and to the available treatment options. Because of the advanced disease at diagnosis observed in the large majority of patients, the commonest treatment option is hormone replacement treatment, mostly orchiectomy [16,31,[39][40][41]. Treatment with intent to cure such as radical prostatectomy and radiation therapy are limited by rarity of localized disease at diagnosis.…”

Section: Prostate Cancer Treatmentmentioning

confidence: 99%

Prostate Cancer in Sub Saharan Africa

Jalloh¹

2013

J. Nephrol. Urol. Res.

View full text Add to dashboard Cite

Prostate cancer is the leading male cancer worldwide. While there are abundant data on the epidemiology, natural history, treatment and outcomes of the disease in the US and many developed countries, prostate cancer is a good example of cancer disparity in that a little is known about the disease in Sub Saharan Africa. Because of the dominant black race in this region and the fact that black men suffer the higher burden of the disease, it is important to understand that cancer in this population. The purpose of this review is to describe the literature of prostate cancer in Sub Saharan Africa. The authors reviewed the published studies on prostate cancer in Sub Saharan Africa available on PubMed. In addition any other accessible study on the topic was included.

show abstract

“…However, limited data are available pertaining to PCa status within Africa. Clinically aggressive disease phenotypes have been reported within selected populations from Western Africa , Eastern Africa , and within an ethnically admixed population from Southern Africa .…”

Section: Introductionmentioning

confidence: 99%

Clinical presentation of prostate cancer in Black South Africans

et al. 2014

View full text Add to dashboard Cite

BackgroundCompared with White Americans, Black American men are at a significant increased risk of presenting with prostate cancer (PCa) and associated mortality, suggesting a link to African-ancestry. However, PCa status within Africa is largely unknown. We address the clinical presentation of PCa within Black South African men.MethodsOver 1,000 participants with or without PCa have enrolled in the Southern African Prostate Cancer Study (SAPCS). Using genome-wide profiling we establish a unique within Africa population substructure. Adjusting for age, clinical variables were assessed, compared against Black Americans and between rural and urban localities while addressing potential socio-demographic confounders.ResultsWe report a significant difference in the distribution of prostate specific antigen (PSA) levels skewed towards higher PSA levels in the PCa cases (83.0% present with a PSA ≥ 20 µg/L; median PSA = 98.8 µg/L) relative to men with no detectable PCa (18.5% present with a PSA ≥ 20 µg/L; median PSA = 9.1 µg/L). Compared with Black Americans, Black South Africans presented with significantly more aggressive disease defined by Gleason score >7 (17% and 36%, respectively) and PSA ≥ 20 µg/L (17.2% and 83.2%, respectively). We report exasperated disease aggression defined by Gleason score >7 (P = 0.0042) and poorly differentiated tumor grade (P < 0.0001) within rural versus urban localities.ConclusionBlack South African men present with higher PSA levels and histopathological tumor grade compared with Black Americans, which is further escalated in men from rural localities. Our data suggests that lack of PSA testing may be contributing to an aggressive PCa disease phenotype within South African men.

show abstract

Descriptive case series of patients presenting with cancer of the prostate and their management at Kenyatta National Hospital, Nairobi

Cited by 14 publications

References 0 publications

Ethnicity and prostate cancer in Southern Nigeria: A preliminary report

Ethnicity and prostate cancer in Southern Nigeria: A preliminary report

Prostate Cancer in Sub Saharan Africa

Clinical presentation of prostate cancer in Black South Africans

Contact Info

Product

Resources

About