Nowadays, the most of studies about the digestive physiology and structure changes during the initial ontogeny of cultured fish, have been focused to describe the indicators (associated with those changes), punctual and reclusively. Moreover, there are not enough indicators, when the digestive morphological and functional changes, are described in certain fish in particular. The present review, try to describe and compile the indicators of digestive morpho functional development, attending the feed habits, as well as the kind of ontogeny that undergo the teleost fish, which, it almost not be considered. The review tries to explain, the importance of show possible synergy between biochemistry (enzymology), histological, histochemical, molecular, mainly genomic aspects (among others); towards an integral and reliable description of the morpho functional changes in the digestive tract of fish. In this sense, the present work, try to elucidate a particular case of Mayaheros urophthalmus (a native species from the Southeast of Mexico), where it has described a pool of indicators associated to the morpho functional changes of its digestive tract. The indicators of digestive morpho functional development can be therefore, complementary mutually. Finally, it has compiled and summarized some indicators of digestive morpho functional changes, towards a better knowledge of the digestive physiology, during the initial ontogeny of teleost fish.