Depth-Resolved Physiological Response of Retina to Transcorneal Electrical Stimulation Measured With Optical Coherence Tomography

Sun, Pengcheng; Li, Qian; Li, Heng; Di, Liqing; Su, Xiaofan; Chen, Jianping; Zheng, Hao; Chen, Yao; Zhou, Chuanqing; Chai, Xinyu

doi:10.1109/tnsre.2019.2912168

Cited by 6 publications

(5 citation statements)

References 56 publications

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“…An initial inflammatory phase following Optic neuritis is characterized by decreased contrast sensitivity across all spatial frequencies (Sun et al, 2019). The current study showed that reduced contrast sensitivity was found among patients with ON.…”

Section: Discussionsupporting

confidence: 54%

Optic Neuritis: Evaluation of Visual Acuity and Contrast Sensitivity. A Hospital Based Cross Sectional Study

Islam

2023

MJMR

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Objective: To assess visual acuity and contrast sensitivity in various form of Optic neuritis patients. Study Design and Settings: It was a hospital based cross sectional study conducted in eye department of Teaching hospital, University of Lahore Pakistan. Total duration of the study was 4 months from January 2022-April 2022. Methods: A total of 32 patients were included in the study. Purposive sampling technique was adopted for sampling. Patients age 15-45 were included in the study. A detailed eye examination was done in patients presented to eye department with pain and evaluated for optic neuritis, and demographics along with clinical signs and symptoms were documented using a proforma. Results: Total 32 patients were included in the study having Optic Neuritis. Mean age of the patients was 29 ±8.3SD (Range 15-45). The optic neuritis was divided into further sub-divisions, i.e. Pappilits 11 patients, Retrobulbar Neuritis 14 patients and neuroretinitis 7 patients. A paired t test comparing contrast sensitivity before and after treatment showed a significance of .03 improvement after treatment. In spite of the fact that the results demonstrated that contrast sensitivity did not return to normal, they did show that with prompt treatment, a substantial improvement in contrast sensitivity was possible. Same significance of .02 was found for improvement in VA post-operatively when a paired t test was applied. Conclusion: Vision and contrast sensitivity both are affected in ON, however VA can be improved to normal vision after treatment, but contrast seldom improve to its normal value.

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Section: Discussionsupporting

confidence: 54%

Optic Neuritis: Evaluation of Visual Acuity and Contrast Sensitivity. A Hospital Based Cross Sectional Study

Islam

2023

MJMR

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“…To exclude these possible causes, our previous work has demonstrated that TES within 3.0 mA would not cause image quality degradation without discernible mosaic imaging artifacts or detectable distortion or thickness changes of retina. 34 And results conflicted with aforementioned studies may be due to the different stimulating electrodes and recording methods.…”

Section: Discussionmentioning

confidence: 87%

“…33 Moreover, our previous study has also discussed the possibility that TES might activate the outer retina. 34 Although the activated TES-evoked retinal layers should be further investigated using methods with higher spatial and depth resolution, there is no doubt that scattering changes are related with the retinal neural responses.…”

Section: Discussionmentioning

confidence: 99%

“…In order to evaluate the IOS changes in different layers, the retina was segmented into three parts in depth: inner retina from inner limiting membrane to outer plexiform layer (OPL), outer retina from OPL to the junction between inner segment of photoreceptor and outer segment of photoreceptor (IS/OS), and subretinal space from IS/OS to retinal pigment epithelium (RPE)-Bruch’s membrane, which was applied by an open source toolbox of OCT retinal segmentation in MATLAB. 34 For each trail, the differential images ΔI were obtained by subtracting the reference image I, which is the mean intensity of OCT signals averaged from the first four images, from all the remaining images in the trail. To increase the SNR, the final ΔI were averaged by two consecutive ΔI.…”

Section: Methodsmentioning

confidence: 99%

“…Our previous work has already demonstrated that TES could elicit neural responses in all retinal segmented layers. 34 Herein, the present study was designed to evaluate neural and vascular responses of retina under TES simultaneously, in order to further investigate neurovascular responses in retina evoked by TES. The study will provide beneficial information on the therapeutic mechanism of TES and a novel technical method to detect retinal neurovascular responses of electrical stimulation.…”

Section: Introductionmentioning

confidence: 99%

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Retinal neurovascular responses to transcorneal electrical stimulation measured with optical coherence tomography

Zheng

et al. 2020

Exp Biol Med (Maywood)

Self Cite

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Noninvasive transcorneal electrical stimulation (TES) has emerged as a potential strategy to facilitate visual restoration and promote retinal cell survival for certain retinal and optic nerve diseases owing to its neuroprotective effects. However, the neurovascular responses of retinal neurons evoked by TES have not been completely determined. To investigate this issue, we utilized a custom-designed spectral-domain optical coherence tomography (SD-OCT) to record the retinal neural and vascular responses under TES in vivo simultaneously. Significant increases of both positive and negative intrinsic optical signal (IOS) changes were recorded in all three segmented retinal layers, which mainly related to neural activities. However, the changes of TES-induced retinal vascular responses, including blood velocity, cross-sectional area of vessel, and blood flow, were not significant. It suggests that TES mainly elicited neural responses in retina, while no significant vascular responses were evoked. Our results provide experimental evidence to the mechanism of retinal neurovascular coupling under TES. Additionally, the present study also suggests that SD-OCT could be utilized as a promoting method to explore neurovascular responses under retinal stimulation in clinical treatment and technology. Impact statement Noninvasive transcorneal electrical stimulation (TES) has emerged as an effective treatment for certain retinal and optic nerve diseases owing to its neuroprotective effects. However, the retinal neurovascular responses evoked by TES have not been completely determined. To investigate this issue, we utilized a custom-designed spectral-domain optical coherence tomography (SD-OCT) to record the retinal neural and vascular responses evoked by TES in vivo simultaneously. The present study suggested that TES mainly elicited neural responses in retina, while no significant vascular responses were evoked. Our results provide experimental evidence to the mechanism of retinal neurovascular coupling evoked by TES. Additionally, the present study also suggests that SD-OCT could be utilized as a promoting method to explore neurovascular responses under retinal electrical stimulation.

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The visual cortical responses to sinusoidal transcorneal electrical stimulation

Zhou

et al. 2022

Brain Research

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Depth-Resolved Physiological Response of Retina to Transcorneal Electrical Stimulation Measured With Optical Coherence Tomography

Cited by 6 publications

References 56 publications

Optic Neuritis: Evaluation of Visual Acuity and Contrast Sensitivity. A Hospital Based Cross Sectional Study

Optic Neuritis: Evaluation of Visual Acuity and Contrast Sensitivity. A Hospital Based Cross Sectional Study

Retinal neurovascular responses to transcorneal electrical stimulation measured with optical coherence tomography

The visual cortical responses to sinusoidal transcorneal electrical stimulation

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