2020
DOI: 10.1177/1535370219900495
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Retinal neurovascular responses to transcorneal electrical stimulation measured with optical coherence tomography

Abstract: Noninvasive transcorneal electrical stimulation (TES) has emerged as a potential strategy to facilitate visual restoration and promote retinal cell survival for certain retinal and optic nerve diseases owing to its neuroprotective effects. However, the neurovascular responses of retinal neurons evoked by TES have not been completely determined. To investigate this issue, we utilized a custom-designed spectral-domain optical coherence tomography (SD-OCT) to record the retinal neural and vascular responses under… Show more

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Cited by 5 publications
(3 citation statements)
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References 45 publications
(71 reference statements)
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“…IOS is defined as the change in intrinsic optical properties after being stimulated, which can be defined as ∆I/I (where ∆I represents change in signal replication caused by the stimulus [36,37], and I represents the signal amplitude before the stimulus). Firstly, B-scan images obtained at the same location were reconstructed and registered, Ten consecutive measurements of the same location were then averaged and the signal-noise-rate(SNR) was thus increased.…”
Section: Ios Changes Processingmentioning
confidence: 99%
“…IOS is defined as the change in intrinsic optical properties after being stimulated, which can be defined as ∆I/I (where ∆I represents change in signal replication caused by the stimulus [36,37], and I represents the signal amplitude before the stimulus). Firstly, B-scan images obtained at the same location were reconstructed and registered, Ten consecutive measurements of the same location were then averaged and the signal-noise-rate(SNR) was thus increased.…”
Section: Ios Changes Processingmentioning
confidence: 99%
“…Both approaches have demonstrated protection effects on the retinal ganglion cells (RGCs) and on the photoreceptors preserved from degeneration processes. This protection mechanism may be due to the increase in certain bioactive factors, for example, insulin-like growth factor 1 (IGF-1), brain-derived neurotrophic factor (BDNF), and ciliary neurotrophic factor (CNTF) [6,[13][14][15][16][17][18][19].…”
Section: Introductionmentioning
confidence: 99%
“…Su et al. 70 reported their investigations on retinal neurovascular responses to transcorneal electrical stimulation (TES). By using SD-OCT to measure the intrinsic optical signal (IOS) and the blood flow parameters, they were able to record simultaneously the neural and vascular responses of the retina to TES in vivo.…”
mentioning
confidence: 99%