“…Furthermore, Isik et al 32 found that total prevalence of anxiety, depression, and mixed anxiety-depressive disorder was 70.8% in patients with RA (of these, 41.5% had depression, 13.4% had anxiety, and 15.9% had mixed anxiety-depressive disorder) and 7.3% in the control group. Mella et al 33 demonstrated that in patients with RA, the prevalence of depression and anxiety symptoms were 53.2% and 48.4%, respectively. Cross sectional and comparative studies in RA reported that age, RA duration, RA activity, morning stiffness, physical disability, functional disability, pain, fatigue, social stress, marital status, worries about partner interest are key predictors of clinical depression.…”