Depressive symptoms and cognitive performance in older adults

Shimada, Hiroyuki; Park, Hye-Jin; Makizako, Hyuma; Doi, Takehiko; Lee, Sangyoon; Suzuki, Takao

doi:10.1016/j.jpsychires.2014.06.004

Cited by 142 publications

(93 citation statements)

References 54 publications

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“…However, the finding in the younger group that those with lifetime depression also show deficits indicates that the biological pathway underlying depression might be constantly impaired. The source of this impairment might stem from differences in brain structure or plasticity of depressed individuals (40,41) or might represent a stable trait, like neuroticism, that is associated with mood states, but does not moderate the relationship between depression and perceptual speed in the elderly (42). The strong genetic correlation between digit symbol performance with both bipolar (43) and major depressive (L. Hall, personal communication) disorders further supports a more enduring biological basis underlying their covariation.…”

Section: Discussionmentioning

confidence: 99%

Current Versus Lifetime Depression, APOE Variation, and Their Interaction on Cognitive Performance in Younger and Older Adults

Luciano

Pujals

Marioni

et al. 2015

Psychosomatic Medicine

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Section: Discussionmentioning

confidence: 99%

Current Versus Lifetime Depression, APOE Variation, and Their Interaction on Cognitive Performance in Younger and Older Adults

Luciano

Pujals

Marioni

et al. 2015

Psychosomatic Medicine

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“…Esses achados sugerem que há um importante componente motivacional para a realização das AAVDs. Sabe-se, no entanto, que os sintomas depressivos influenciam negativamente a cognição de idosos (Plati, Covre, Lukasova, & Macedo, 2006;Rook, Mavandadi, Sorkin, & Zettel, 2007;Shimada et al, 2014), predizendo o declínio cognitivo (Paterniti, Verdier-Taillefer, Dufouil, & Alpérovitch, 2002).…”

Section: Discussionunclassified

“…Em estudo recente, Shimada et al (2014) observaram que idosos com sintomas depressivos, além de apresentaram pior desempenho cognitivo, manifestaram menor concentração sérica de Brain derived neurotrophic fator (BDNF) e maior atrofia no lobo temporal medial direito, quando comparados a idosos sem sintomas depressivos. Desse modo, os sintomas depressivos em idosos podem explicar menor engajamento em atividades complexas e pior desempenho cognitivo.…”

Section: Discussionunclassified

Atividades Avançadas de Vida Diária (AAVD) e desempenho cognitivo entre idosos

et al. 2015

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ResumoO estudo objetivou investigar a associação entre Atividades avançadas de vida diária (AAVD) e o desempenho cognitivo entre idosos participantes do estudo FIBRA em Ermelino Matarazzo, São Paulo. Foram investigados 302 idosos sem declínio cognitivo, classificados em muito ativos e pouco ativos nas AAVDs, e avaliados pelo Mini exame do estado mental (MEEM), bateria breve de rastreio cognitivo (BBRC), fluência verbal (FV), teste do desenho do relógio (TDR) e escala de depressão geriátrica (EDG). As AAVDs associaram-se ao desempenho no MEEM e no TDR, nas análises univariadas, mas esta associação perdeu significância no modelo multivariado. O desempenho, no MEEM, esteve associado à idade, escolaridade, sexo e número de sintomas depressivos. O escore, no TDR, associou-se à escolaridade. Conclui-se que a relação entre as AAVDs e o desempenho cognitivo parece ser modulada por variáveis sociodemográficas e por sintomas depressivos. Palavras-chave: idoso; cognição; lazer. Advanced Activities of Daily Living (AADL) and cognitive performance among older adults AbstractThis study aimed to investigate the association between advanced activities of daily living (AADL) and cognitive performance in a community of dwelling older adults participants of the FIBRA study in Ermelino Matarazzo, São Paulo. 302 older adults without cognitive decline, classified as very active or little active in AADLs, were assessed by the Mini-Mental State Examination (MMSE), Brief Cognitive Screening Battery (BCSB), Verbal Fluency (VF), Clock Drawing Test (CDT), and Geriatric Depression Scale (GDS). The AADLs were associated with performance in the MMSE and CDT in univariate analyses, but the association lost statistical significance in the multivariate model. The MMSE score was associated with age, education, sex and depression symptoms. The CDT score was associated with education. The association between AADLs and cognitive performance seems to be modulated by socio-demographic variables and the number of depression symptoms. Actividades Avanzadas de la Vida Diaria (AAVD) y desempeño cognitivo entre ancianosResumen Este estudio investigó la asociación entre las Actividades Avanzadas de la Vida Diaria (AAVD) y el desempeño cognitivo entre las personas ancianas, participantes del Estudio FIBRA, en Ermelino Matarazzo, San Pablo. Fueron investigadas 302 ancianos, sin deterioro cognitivo, clasificados en muy activos y poco activos en las AAVD, y evaluadas por el Mini-Examen del Estado Mental (MEEM), la Batería Breve de Rastreo Cognitivo (BBRC), Fluidez Verbal (FV), Test del Dibujo del Reloj (TDR), y la Escala de Depresión Geriátrica (EDG). Las AAVD se asociaron con el rendimiento en el MEEM y en el TDR en los análisis univariados, pero perdieron importancia en el modelo multivariado. El desempeño en el MEEM estuvo asociado a la edad, escolaridad, sexo y número de síntomas depresivos. El resultado en el TDR se asoció a la escolaridad. La relación entre el rendimiento cognitivo y las AAVD parece estar regido por las variables sociodemográficas y por sí...

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“…Cross-sectional studies have demonstrated a significant association between depressive symptoms and cognitive decline, while other studies have found no association. [3][4][5] In longitudinal studies, evidence suggests depressive symptoms at baseline predicted future cognitive decline, with significant associations between chronic or persistent symptoms of depression and declines in attention, memory, general cognitive status, and executive functions, 3,6 although there have been some inconsistencies across studies. 7 Other research has shown depressive symptoms and related executive function impairment may better represent prodromal symptoms of dementia that reflect common causes of these conditions.…”

Section: Introductionmentioning

confidence: 99%

Influence of Spirituality on Depression-Induced Inflammation and Executive Functioning in a Community Sample of African Americans

et al. 2019

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African Americans (AAs) are disproportionately affected by cerebrovascular pathology and more likely to suffer from premature cognitive decline. Depression is a risk factor for poorer cognitive functioning, and research is needed to identify factors that serve to mitigate its negative effects. Studies have demonstrated positive influences of spirituality within the AA community. Determining whether spirituality attenuates the effects of depressive symptoms on cognitive functioning and the pathophysiological mechanisms that explain these relationships in AAs is paramount. This study examines the influence of daily spiritual experiences on the relationship between depressive symptoms and cognitive functioning, and how inflammatory markers may partially explain these associations. A sample of 212 (mean age= 45.6) participants completed the Daily Spiritual Experience Scale (DSES), Beck Depression Inventory-II (BDI-II), Trail Making Test A and B (TMT) and Stroop Color and Word Test (Stroop). Blood samples were collected to measure inflammatory mediators (IL-6, IL-1a, TNF-a). Linear regression analyses were used to evaluate associations. Higher BDI-II scores were associated with poorer psychomotor speed and visual scanning, measured by TMT A (B=1.49, P=.01). IL-6 explained a significant amount of variance in this relationship (B=.24, CI 95% [.00, .64]). IL-6 also significantly mediated the relationship between depressive symptoms and psychomotor speed and mental flexibility, measured by TMT B performance (B=.03, CI 95% [.003, .095]). Frequent spiritual experiences among AAs may ameliorate the negative influence of depressive symptoms on cognitive functioning.Ethn Dis. 2019;29(2):267-276; doi:10.18865/ed.29.2.267

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Depressive symptoms and cognitive performance in older adults

Cited by 142 publications

References 54 publications

Current Versus Lifetime Depression, APOE Variation, and Their Interaction on Cognitive Performance in Younger and Older Adults

Current Versus Lifetime Depression, APOE Variation, and Their Interaction on Cognitive Performance in Younger and Older Adults

Atividades Avançadas de Vida Diária (AAVD) e desempenho cognitivo entre idosos

Influence of Spirituality on Depression-Induced Inflammation and Executive Functioning in a Community Sample of African Americans

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