Current Versus Lifetime Depression, APOE Variation, and Their Interaction on Cognitive Performance in Younger and Older Adults

Luciano, Michelle; Pujals, Ana Maria Fernández; Marioni, Riccardo E.; Campbell, Archie; Hayward, Caroline; MacIntyre, Donald J.; Porteous, David J.; McIntosh, Andrew M.; Deary, Ian J.

doi:10.1097/psy.0000000000000190

Cited by 12 publications

(8 citation statements)

References 51 publications

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“…The association between self-rated memory and depressive symptom severity in older adults is well established (Kahn et al, 1975;Grut et al, 1993;Collins and Abeles, 1996;Jonker et al, 1996;Derouesne et al, 1999;Clarnette et al, 2001;Pearman and Storandt, 2004;Minett et al, 2005). Given the equally wellestablished link between depressive symptoms and cognition in older adults, (e.g., Burt et al, 1995;Koenig et al, 2015;Luciano et al, 2015;O'Shea et al, 2015), it is surprising that the association between subjective memory and objective memory performance is less clearly delineated in the literature. While some studies report an association (Gagnon et al, 1994;Jonker et al, 1996), other studies have not (Stewart et al, 2001;Jungwirth et al, 2004;Rickenbach et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Older adults with poor self‐rated memory have less depressive symptoms and better memory performance when perceived self‐efficacy is high

O’Shea

Dotson

Fieo³

et al. 2015

Int J Geriat Psychiatry

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Objective To investigate whether self-efficacy moderates the association between self-rated memory and depressive symptoms in a large sample of older adults. The influence of self-efficacy and depressive symptoms on memory performance was also examined in a subsample of individuals who reported poor memory. Methods Non-demented participants (n=3766) were selected from the 2012 wave of the Health and Retirement Study. Depressive symptomatology was assessed with the 8-item Center for Epidemiologic Studies Depression Scale. A modified version of the Midlife Developmental Inventory Questionnaire was used as the measure of self-efficacy. Participants were asked to rate their memory presently on a five-point scale from Excellent (1) to Poor (5). Immediate memory and delayed memory (after a 5-min interval) were measured by the number of correct words recalled from a 10-item word list. Results Multiple regression analyses revealed that negative ratings of memory were significantly associated with greater levels of depressive symptoms, with this effect being greatest in those with low levels of self-efficacy. Additionally, greater self-efficacy was associated with optimal objective memory performances but only when depressive symptoms were low in individuals who reported poor memory function (n=1196). Conclusion Self-efficacy moderates the relationship between self-rated memory function and depressive symptoms. Higher self-efficacy may buffer against the impact of subjective memory difficulty on one’s mood and thereby mitigating the effect of depressive symptoms on memory. Interventions should focus on increasing perceived self-efficacy in older adults reporting poor memory function to potentially minimize memory impairment.

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Section: Introductionmentioning

confidence: 99%

Older adults with poor self‐rated memory have less depressive symptoms and better memory performance when perceived self‐efficacy is high

O’Shea

Dotson

Fieo³

et al. 2015

Int J Geriat Psychiatry

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“…With respect to the moderating effect of APOE E4 status, an important between-study variable is the measurement of key phenotypes. Studies that have used multiple cognitive tests and non-dichotomous depressive symptomatology measures have tended not to find the interaction (the present study, [ 22 , 23 ]; cf. [ 21 ]), whereas those that have used a cognitive impairment screener or clinical diagnosis of cognitive impairment along with a dichotimization or clinical diagnosis of depressive symptomatology have tended to find the interaction [ 12 – 18 ].…”

Section: Discussionmentioning

confidence: 80%

Apolipoprotein E genotype does not moderate the associations of depressive symptoms, neuroticism and allostatic load with cognitive ability and cognitive aging in the Lothian Birth Cohort 1936

et al. 2018

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ObjectivesIn this replication-and-extension study, we tested whether depressive symptoms, neuroticism, and allostatic load (multisystem physiological dysregulation) were related to lower baseline cognitive ability and greater subsequent cognitive decline in older adults, and whether these relationships were moderated by the E4 allele of the apolipoprotein E (APOE) gene. We also tested whether allostatic load mediated the relationships between neuroticism and cognitive outcomes.MethodsWe used data from the Lothian Birth Cohort 1936 (n at Waves 1–3: 1,028 [M age = 69.5 y]; 820 [M duration since Wave 1 = 2.98 y]; 659 [M duration since Wave 1 = 6.74 y]). We fitted latent growth curve models of general cognitive ability (modeled using five cognitive tests) with groups of APOE E4 non-carriers and carriers. In separate models, depressive symptoms, neuroticism, and allostatic load predicted baseline cognitive ability and subsequent cognitive decline. In addition, models tested whether allostatic load mediated relationships between neuroticism and cognitive outcomes.ResultsBaseline cognitive ability had small-to-moderate negative associations with depressive symptoms (β range = -0.20 to -0.17), neuroticism (β range = -0.27 to -0.23), and allostatic load (β range = -0.11 to 0.09). Greater cognitive decline was linked to baseline allostatic load (β range = -0.98 to -0.83) and depressive symptoms (β range = -1.00 to -0.88). However, APOE E4 allele possession did not moderate the relationships of depressive symptoms, neuroticism and allostatic load with cognitive ability and cognitive decline. Additionally, the associations of neuroticism with cognitive ability and cognitive decline were not mediated through allostatic load.ConclusionsOur results suggest that APOE E4 status does not moderate the relationships of depressive symptoms, neuroticism, and allostatic load with cognitive ability and cognitive decline in healthy older adults. The most notable positive finding in the current research was the strong association between allostatic load and cognitive decline.

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“…X chromosome polygenic scores were calculated in unrelated individuals from Generation Scotland [32] separately for men and women based on the sex-stratified association analyses. These were used to predict Eysenck Personality Questionnaire neuroticism scores, General Health Questionnaire 28-item [36] total scores (i.e., general psychological distress), and Structured Clinical Interview for DSM-IV (SCID)-diagnosed depressive disorder [37]. Following FDR correction, none of the results were significant (P > .05; Supplementary Table 5).…”

Section: Resultsmentioning

confidence: 99%

The influence of X chromosome variants on trait neuroticism

et al. 2019

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Autosomal variants have successfully been associated with trait neuroticism in genome-wide analysis of adequately powered samples. But such studies have so far excluded the X chromosome from analysis. Here, we report genetic association analyses of X chromosome and XY pseudoautosomal single nucleotide polymorphisms (SNPs) and trait neuroticism using UK Biobank samples (N = 405,274). Significant association was found with neuroticism on the X chromosome for 204 markers found within three independent loci (a further 783 were suggestive). Most of the lead neuroticism-related X chromosome variants were located in intergenic regions (n = 397). Involvement of HS6ST2, which has been previously associated with sociability behaviour in the dog, was supported by single SNP and gene-based tests. We found that the amino acid and nucleotide sequences are highly conserved between dogs and humans. From the suggestive X chromosome variants, there were 19 nearby genes which could be linked to gene ontology information. Molecular function was primarily related to binding and catalytic activity; notable biological processes were cellular and metabolic, and nucleic acid binding and transcription factor protein classes were most commonly involved. X-variant heritability of neuroticism was estimated at 0.22% (SE = 0.05) from a full dosage compensation model. A polygenic X-variant score created in an independent sample (maximum N ≈ 7,300) did not predict significant variance in neuroticism, psychological distress, or depressive disorder. We conclude that the X chromosome harbours significant variants influencing neuroticism, and might prove important for other quantitative traits and complex disorders.

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Current Versus Lifetime Depression, APOE Variation, and Their Interaction on Cognitive Performance in Younger and Older Adults

Cited by 12 publications

References 51 publications

Older adults with poor self‐rated memory have less depressive symptoms and better memory performance when perceived self‐efficacy is high

Older adults with poor self‐rated memory have less depressive symptoms and better memory performance when perceived self‐efficacy is high

Apolipoprotein E genotype does not moderate the associations of depressive symptoms, neuroticism and allostatic load with cognitive ability and cognitive aging in the Lothian Birth Cohort 1936

The influence of X chromosome variants on trait neuroticism

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