Depressive Disorder Subtypes as Predictors of Incident Obesity in US Adults: Moderation by Race/Ethnicity

Examining clinical features of depressive episodes may help elucidating the nature of association between depression and obesity, related to specific symptoms such as appetite and weight changes. This meta-analysis of observational studies evaluated whether subtypes of depression are associated with specific anthropometric profiles in adults. We searched MEDLINE, LILACS, PsycINFO, Scopus, Web of Science databases, and Grey Literature for articles published up to October 2016 that examined depressive subtypes and adiposity measures among adults. The pooled effect size was estimated with random effects models. The PRISMA guidelines were adopted to reporting results, and this review was registered in PROSPERO (CRD42016035685). A total of 22 articles were included in this systematic review, of which eight had data included in the meta-analysis, assessing 14 757 individuals with depression. Patients with atypical depression presented a 2.55 higher BMI score compared with those with melancholic depression. Subgroup analysis identified a differential distribution of anthropometric measures in studies conducted with Chinese populations. Among the remainder studies, only one reported discrepant results, possibly due to the exclusion of "weight change" in defining subtypes of depression.Atypical depression was significantly associated with elevated BMI compared with melancholic depression, deserving particular attention due to its clinical importance. KEYWORDSatypical depression, body mass index, melancholic depression, meta-analysis

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“…Most of them (4/15) were conducted in the United States. The sample size of people with MDD ranged from 7 to 5092—NESARC (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…In addition, drugs used to treat depression often present with weight gain as an adverse effect, which, along with inadequate lifestyle (poor diet quality and physical inactivity), usually adopted during depressive episodes, may increase the risk of obesogenic consequences …”

Section: Discussionmentioning

confidence: 99%

Depression subtypes and obesity in adults: A systematic review and meta‐analysis

Silva

Coutinho²,

Ferriani

et al. 2019

Obesity Reviews

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“…Although >300 million people worldwide experience depression, in China alone, this number has been reported to be 54 million. 2 Research has shown that depression is closely related to unhealthy lifestyles, 3 physical illness, 4 suicide 5 6 and disease burden. [7][8][9] College students, who are in the transitional period from puberty to adulthood, are a special group because they begin to face problems in various aspects, for example, issues in interpersonal relationships, academic pressure and financial difficulties, which they must face independently and make important life decisions.…”

Section: Introductionmentioning

confidence: 99%

Depression and its correlation with social support and health-promoting lifestyles among Chinese university students: a cross-sectional study

2021

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ObjectivesTo investigate the prevalence of depression in college students and determine how social support and healthy lifestyle factors are associated with depression in this population.DesignA cross-sectional design.SettingA comprehensive university in Changsha, Hunan, South China. The study was conducted from May to June 2019.ParticipantsA total of 541 students at the comprehensive university.Primary and secondary outcome measuresThe Zung Self-Rating Depression Scale, Social Support Rating Scale and Health-Promoting Lifestyle Profile-II (HPLP-II) were used to evaluate depression, social support and lifestyles, respectively, and analyse the mutual relationships among them.ResultsAmong the 541 participants, 161 (29.8%) experienced depressive symptoms, and there were significant gender-related and academic discipline-related differences in self-rated depression. The average social support score was 38.06 (38.06±7.52). The average HPLP-II score was 71.09 (71.09±11.47). A monofactor analysis showed that depression was correlated with social support and a healthy lifestyle. As demonstrated by logistic regression analysis, being a woman (OR=2.613, 95% CI: 1.541 to 4.43), inadequate social support (OR=0.912, 95% CI: 0.877 to 0.948), poor nutrition (OR=0.87, 95% CI: 0.775 to 0.977) and lack of self-actualisation (OR=0.644, 95% CI: 0.572 to 0.724) were significantly correlated with depression.ConclusionsOwing to the high prevalence of depression among Chinese university students, educational institutions must take measures such as providing compulsory mental health education courses and improving the psychological counselling services available to students.

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“…Adults with melancholic features of depression did not have higher increases in fasting glucose over this period 8 . Atypical depression is also longitudinally associated with other indicators of metabolic dysregulation, including increased obesity, metabolic syndrome, and inflammatory markers 9 , 10 . Findings from these studies suggest that adults with depression-related weight gain, a component of atypical depression, may have a higher risk of type 2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

Depression-related weight change and incident diabetes in a community sample

Graham

Watson

Deschênes

et al. 2021

Sci Rep

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This cohort study aimed to compare the incidence of type 2 diabetes in adults with depression-related weight gain, depression-related weight loss, depression with no weight change, and no depression. The study sample included 59,315 community-dwelling adults in Ontario, Canada. Depression-related weight change in the past 12 months was measured using the Composite International Diagnostic Interview—Short Form. Participants were followed for up to 20 years using administrative health data. Cox proportional hazards models compared the incidence of type 2 diabetes in adults with depression-related weight change and in adults with no depression. Adults with depression-related weight gain had an increased risk of type 2 diabetes compared to adults no depression (HR 1.70, 95% CI 1.32–2.20), adults with depression-related weight loss (HR 1.62, 95% CI 1.09–2.42), and adults with depression with no weight change (HR 1.39, 95% CI 1.03–1.86). Adults with depression with no weight change also had an increased risk of type 2 diabetes compared to those with no depression (HR 1.23, 95% CI 1.04–1.45). Associations were stronger among women and persisted after adjusting for attained overweight and obesity. Identifying symptoms of weight change in depression may aid in identifying adults at higher risk of type 2 diabetes and in developing tailored prevention strategies.

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Depressive Disorder Subtypes as Predictors of Incident Obesity in US Adults: Moderation by Race/Ethnicity

Cited by 29 publications

References 47 publications

Depression subtypes and obesity in adults: A systematic review and meta‐analysis

Depression subtypes and obesity in adults: A systematic review and meta‐analysis

Depression and its correlation with social support and health-promoting lifestyles among Chinese university students: a cross-sectional study

Depression-related weight change and incident diabetes in a community sample

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