Depression subtypes and obesity in adults: A systematic review and meta‐analysis

Silva, Daniela; Coutinho, Evandro Silva Freire; Ferriani, Lara Onofre; Viana, María Carmen

doi:10.1111/obr.12966

Cited by 59 publications

(41 citation statements)

References 53 publications

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“…The high rate of comorbidities and frequent use of medications in our study participants may be explained by the strong association between obesity and more than 20 comorbidities (8,16) and the fact that the study was conducted at a tertiary hospital. The substantial use of antidepressant agents by individuals with obesity, as observed among individuals with obesity classes 2 and 3 in the present study, has been previously described (17) and seems to be worse the greater the BMI (18).…”

Section: Number Of Fracturessupporting

confidence: 79%

Association between fractures and traditional risk factors for osteoporosis and low bone mineral density in patients with obesity

Sampaio¹,

Marques²,

Petterle³

et al. 2021

Archives of Endocrinology and Metabolism

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Objective: To evaluate the reasons for request of bone mineral density (BMD) evaluation and correlate the BMD results with previous fractures, risk factors for osteoporosis, and clinical characteristics in patients with obesity. Subjects and methods: Cross-sectional, retrospective, single-site study including adult patients with body mass index (BMI) ≥ 30 kg/m 2 and BMD evaluation between January 2015 and May 2016 selected from a BMD database. Data on demographic characteristics, lifestyle habits, comorbidities, medications, risk factors, previous fractures, and indications for BMD evaluation were collected from the participants' medical records. Results: The study included 619 patients (89.9% women, mean BMI 34.79 ± 4.05 kg/m 2). In all, 382 (61.7%), 166 (26.8%), and 71 (11.5%) patients had class 1, 2, and 3 obesity, respectively. The most frequent (29.9%) reason for BMD evaluation was for osteoporosis monitoring. In all, 69.4% of the patients had low BMD. Multivariate analysis showed that age, calcium supplementation, and previous osteoporosis or osteopenia were associated with low BMD, while age, vitamin D supplementation, use of proton pump inhibitors (PPIs), and low BMD were associated with previous fractures (p < 0.05 for all). Conclusions: Among patients with obesity identified from a tertiary hospital database, those with low bone mass and risk factors traditionally associated with fractures had an increased history of fractures. Patients with greater BMI had better bone mass and fewer fractures. These findings indicate that the association between reduced weight, risk factors for osteoporosis, and fractures remained despite the presence of obesity in our population.

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Section: Number Of Fracturessupporting

confidence: 79%

Association between fractures and traditional risk factors for osteoporosis and low bone mineral density in patients with obesity

Sampaio¹,

Marques²,

Petterle³

et al. 2021

Archives of Endocrinology and Metabolism

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“…Moreover, we found that patients receiving these interventions benefited from body mass index reduction. Obesity is common in patients with major depression and may influence psychiatric trajectory [31,32]. Intentional weight loss improves the symptoms of depression [10].…”

Section: Discussionmentioning

confidence: 99%

Fasting Interventions for Stress, Anxiety and Depressive Symptoms: A Systematic Review and Meta-Analysis

et al. 2021

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Background. Fasting interventions have shown effectiveness in alleviating stress, anxiety and depressive symptoms. However, no quantitative analysis has been carried out thus far. The objective was to determine the effectiveness of fasting interventions on stress, anxiety and depression and if these interventions were associated with increased or decreased fatigue/energy. Methods. Overall, 11 studies and 1436 participants were included in the quantitative analyses. Results. After limiting analyses to randomized controlled trials with low risk of bias, we found that fasting groups had lower anxiety (b = −0.508, p = 0.038), depression levels (b= −0.281, p = 0.012) and body mass index compared to controls without increased fatigue. There was no publication bias and no heterogeneity for these results. These interventions were safe, even in patients with type 2 diabetes. Conclusions. These results should be taken with a caveat. These results are preliminary and encouraging and fasting appears to be a safe intervention. Data are not sufficient to recommend one fasting intervention more than the others. No study was carried out in psychiatric populations and further trials should be carried out in these populations that may be good candidates for fasting interventions.

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“…Obesity in MDD is characterized by atypical features, anxiety symptoms, and chronic course. 24 , 25 A meta-analysis of nine longitudinal studies including 7,196 subjects found that depression increased the odds of obesity at follow-up (odds ratio [OR] 1.58; 95% confidence interval [95%CI] 1.33-1.87). 26 Regarding BD, the prevalence of obesity is also increased, especially in patients with higher rates of depressive episodes.…”

Section: Resultsmentioning

confidence: 99%

Physical health in affective disorders: a narrative review of the literature

Colomer

Anmella

Vieta

et al. 2021

Braz. J. Psychiatry

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This article reviews the most common non-psychiatric comorbidities associated with affective disorders, examining the implications of their possible bidirectional link. A narrative review was conducted on the association among the three most common non-psychiatric diseases in major depressive disorder and bipolar disorder (obesity, metabolic syndrome, and cardiovascular diseases) in articles published from January 1994 to April 2020. The evidence suggests that obesity, metabolic syndrome, and cardiovascular diseases are highly prevalent in patients diagnosed with affective disorders. The presence of non-psychiatric comorbidities significantly worsens the therapeutic management and prognosis of affective disorders and vice versa. In many cases, these comorbidities may precede the onset of affective disorders, although in most cases they appear after it. The presence of these concurrent non-psychiatric diseases in an individual diagnosed with an affective disorder is associated with a more complex disease presentation and management. For professionals, the evidence unequivocally supports routine surveillance of comorbidities from a multidisciplinary approach.

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Depression subtypes and obesity in adults: A systematic review and meta‐analysis

Cited by 59 publications

References 53 publications

Association between fractures and traditional risk factors for osteoporosis and low bone mineral density in patients with obesity

Association between fractures and traditional risk factors for osteoporosis and low bone mineral density in patients with obesity

Fasting Interventions for Stress, Anxiety and Depressive Symptoms: A Systematic Review and Meta-Analysis

Physical health in affective disorders: a narrative review of the literature

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