Depressive Affect and Survival Among Gay and Bisexual Men Infected With HIV

Mayne, Tracy J.

doi:10.1001/archinte.1996.00440180095012

Cited by 153 publications

(40 citation statements)

References 34 publications

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“…Thus, specific impairments in NK cell function may compromise the host's natural resistance against HIV. These HIV effects on NK cell function, coupled with the reports of reduced NK cell activity in depression, including depressed HIV-infected individuals, could underlie the findings from studies suggesting that depression adversely affects HIV disease progression in prospective clinical investigations of HIV-seropositive individuals (11,13,14,17,18,(86)(87)(88).…”

Section: Discussionmentioning

confidence: 97%

“…Increasing evidence suggests that depression is a potential risk factor for the morbidity and mortality in other medical diseases, including HIV/AIDS (10)(11)(12)(13)(14)(15)(16)(17)(18)(19). Depression has been associated with alterations in cellular immunity, including NK cell numbers and NK cell cytotoxicity (20)(21)(22)(23)(24) in individuals who are depressed but without other medical illnesses.…”

mentioning

confidence: 99%

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Selective Serotonin Reuptake Inhibitor and Substance P Antagonist Enhancement of Natural Killer Cell Innate Immunity in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome

Evans

Lynch

Benton

et al. 2008

Biological Psychiatry

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Background-Natural killer (NK) cells play an important role in innate immunity and are involved in the host defense against human immunodeficiency virus (HIV) infection. This study examines the potential role of three underlying regulatory systems that have been under investigation in central nervous system research as well as immune and viral research: serotonin, neurokinin, and glucocorticoid systems.

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Section: Discussionmentioning

confidence: 97%

mentioning

confidence: 99%

Selective Serotonin Reuptake Inhibitor and Substance P Antagonist Enhancement of Natural Killer Cell Innate Immunity in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome

Evans

Lynch

Benton

et al. 2008

Biological Psychiatry

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“…To our knowledge, this is the first time that changes in dietary intake have been associated with depression in persons with HIV. Depression has been associated with increased mortality in a number of studies [39][40][41][42] , but the mechanisms that might explain the association are not known. Our findings suggest that poor nutrition should be explored as a potential contributing factor.…”

Section: Discussionmentioning

confidence: 99%

Declines in dietary macronutrient intake in persons with HIV infection who develop depression

Isaac

Jacobson

Wanke

et al. 2008

Public Health Nutr.

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Background: The effect of depression on dietary intake has not, to our knowledge, been examined in persons with HIV infection. Methods: We conducted a longitudinal analysis of participants in the Nutrition for Healthy Living Study (NFHL). We measured changes in dietary macronutrient intake in participants who developed depression and, using multiple regression analysis, compared the changes with a control group of patients who did not become depressed. Results: Ninety patients developed depression during the observation period, and we compared these with 152 non-depressed controls. The two groups had similar age and body mass index (BMI) at baseline, but those who developed depression were more likely to be female, less educated and had lower incomes. After adjustment, compared with non-depressed participants, those who developed depression had significantly greater decreases in the following daily intakes: total energy (2341 kcal, P 5 0.006), protein (212.3 g, P 5 0.02), total fat (218.5 g, P 5 0.008), carbohydrate (236.8 g, P 5 0.02), total fibre (24.3 g, P 5 0.001) and saturated fat (26.7 g, P 5 0.01). There were no significant differences in the daily intakes of simple sugars and long-chain n23 fatty acids, or BMI. Conclusion: Depression is associated with decreases in total daily energy intake and in six of the eight dietary components we measured. Clinicians should be aware that depression-associated nutritional deficiencies may complicate the care of persons with HIV.

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“…In several PNI-related studies with the HIV-infected population, clear associations have been demonstrated between psychological distress and immunosuppression or disease progression (e.g., Antoni, 2003;Herbert & Cohen, 1993;Leserman et al, 2002;Mayne, Vittinghoff, Chesney, Barrett, & Coates, 1996;Patterson et al, 1996). Such relationships could be due to a number of causal factors, including declines in lymphocyte function and numbers, altered expression of immunoregulatory cytokines, changes in neuropeptide or hormone levels (particularly cortisol), and reduced NKC or T-lymphocyte cytotoxicity (Bollinger & Siliciano, 1992;Pitzalis et al, 1997;Rosenberg, Anderson, & Pabst, 1998).…”

Section: Introductionmentioning

confidence: 99%

A randomized clinical trial of alternative stress management interventions in persons with HIV infection.

McCain¹,

Gray²,

Elswick³

et al. 2008

Journal of Consulting and Clinical Psychology

127

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Research in psychoneuroimmunology suggests that immunosuppression associated with perceived stress may contribute to disease progression in persons with HIV infection. While stress management interventions may enhance immune function, few alternative approaches have yet been tested. This randomized clinical trial was conducted to test effects of three 10-week stress management approaches-cognitive-behavioral relaxation training (RLXN), focused tai chi training (TCHI), and spiritual growth groups (SPRT)-in comparison to a wait-listed control group (CTRL) among 252 individuals with HIV infection. Using repeated measures mixed modeling, the authors found that in comparison to the CTRL group, (a) both the RLXN and TCHI groups used less emotion-focused coping, and (b) all treatment groups had augmented lymphocyte proliferative function. Despite modest effects of the interventions on psychosocial functioning, robust findings of improved immune function have important clinical implications, particularly for persons with immune-mediated illnesses.

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Depressive Affect and Survival Among Gay and Bisexual Men Infected With HIV

Cited by 153 publications

References 34 publications

Selective Serotonin Reuptake Inhibitor and Substance P Antagonist Enhancement of Natural Killer Cell Innate Immunity in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome

Selective Serotonin Reuptake Inhibitor and Substance P Antagonist Enhancement of Natural Killer Cell Innate Immunity in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome

Declines in dietary macronutrient intake in persons with HIV infection who develop depression

A randomized clinical trial of alternative stress management interventions in persons with HIV infection.

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