Selective Serotonin Reuptake Inhibitor and Substance P Antagonist Enhancement of Natural Killer Cell Innate Immunity in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome

Evans, Dwight L.; Lynch, Kevin G.; Benton, Tami D.; Dubé, B; Gettes, David R.; Tustin, Nancy B.; Lai, Jianping; Metzger, David S.; Douglas, Steven D.

doi:10.1016/j.biopsych.2007.08.012

Cited by 59 publications

(68 citation statements)

References 87 publications

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“…Cortisol has immunosuppressive effects and inhibits NK cell activity [30]. In this study, plasma cortisol levels were decreased after treatment for both responders and non-responders.…”

Section: Discussionmentioning

confidence: 48%

Natural killer cell activity in patients with major depressive disorder treated with escitalopram

Park

Lee

Jeong

et al. 2015

International Immunopharmacology

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“…Cortisol has immunosuppressive effects and inhibits NK cell activity [30]. In this study, plasma cortisol levels were decreased after treatment for both responders and non-responders.…”

Section: Discussionmentioning

confidence: 48%

Natural killer cell activity in patients with major depressive disorder treated with escitalopram

Park

Lee

Jeong

et al. 2015

International Immunopharmacology

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“…Our investigations [2,[20][21][22][23][24][25][26] have demonstrated the presence of NK1 receptors at mRNA and protein levels in cells of the human immune system and the nervous system, including human peripheral blood mononuclear cells (PBMC) [2], lymphocytes [20] and microglia [21]. SP triggers functional responses in many cells of the immune system, including monocytes and macrophages [2], lymphocytes [20], microglia [21], natural killer cells [27] and precursors of immune cells [15].…”

Section: Functional Differences Between Full Length and Truncated Nk1rmentioning

confidence: 99%

Neurokinin 1 receptor isoforms and the control of innate immunity

Tuluc¹,

Lai²,

Kilpatrick³

et al. 2009

Trends in Immunology

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“…Recent evidence has also shown that decidual NK (dNK) cells play a key role in controlling trophoblast invasion and vascular remodeling (33,34). Although NK cells are an important cell type within the innate immune system and also act as sentinel cells in other models (35)(36)(37), their exact function at the maternal-fetal interface remains incompletely defined. Recent studies have reported that CD27, which belongs to the TNF receptor family, is an important marker in distinguishing different subsets of NK cells (38,39).…”

mentioning

confidence: 99%

Natural killer cells promote immune tolerance by regulating inflammatory T_H17 cells at the human maternal–fetal interface

Sun

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

243

218

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Natural killer (NK) cells accumulate at the maternal-fetal interface in large numbers, but their exact roles in successful pregnancy remain poorly defined. Here, we provide evidence that T H 17 cells and local inflammation can occur at the maternal-fetal interface during natural allogenic pregnancies. We found that decidual NK cells promote immune tolerance and successful pregnancy by dampening inflammatory T H 17 cells via IFN-γ secreted by the CD56 bright CD27 + NK subset. This NK-cell-mediated regulatory response is lost in patients who experience recurrent spontaneous abortions, which results in a prominent T H 17 response and extensive local inflammation. This local inflammatory response further affects the regulatory function of NK cells, leading to the eventual loss of maternal-fetal tolerance. Thus, our data identify NK cells as key regulatory cells at the maternal-fetal interface by suppressing T H 17-mediated local inflammation.regulatory NK cells | fetomaternal tolerance D uring pregnancy, allogeneic fetal cells invade the maternal decidua but they are protected from the maternal immune system. This invasion of extraembryonic trophoblasts does not harm gestation during normal pregnancy; it establishes tolerance at the maternal-fetal interface (1), (2), although the mechanism of such tolerance is not clear. In addition, inflammatory responses induced by a variety of mechanisms can result in embryo loss, but mild inflammation can be effectively controlled through regulatory mechanisms to maintain successful pregnancy (3). Thus, suppression of strong inflammatory responses is essential to ensure normal pregnancy (4, 5), although the mechanisms involved in regulating local inflammation without compromising overall maternal immunity during a successful pregnancy remain unknown.Multiple mechanisms are potentially involved in promoting immune tolerance during pregnancy. For example, T H 2 cytokine polarization (6-9), the expression of the Fas ligand on trophoblast cells (10), and the inhibition of complement activation (11) are crucial for ensuring tolerance at the maternal-fetal interface. In addition, a delicate balance exists between inhibitory (PD-L1, Stat3, and TGF-β1) and stimulatory (CD80 and CD86) signals during the establishment of immune privilege (12-18). Furthermore, studies have shown that galectin-1 (19) and indoleamine 2,3-dioxygenase (20) play pivotal roles in maternal-fetal tolerance. Several types of immune cells, such as CD4 + CD25 + regulatory T cells, are also essential in the generation of maternal-fetal tolerance in mice and humans (7,(21)(22)(23)(24). Furthermore, natural killer (NK) T cells and immature dendritic cells have been reported to promote the expansion of Treg cells that confer protection of the fetus (19).Despite considerable progress, many questions remain unanswered. The most striking feature at the maternal-fetal interface is the accumulation of NK cells, which account for ∼60-90% of immune cells in the decidua in humans during early pregnancy (25)(26)(27)(28)(29) and a...

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Selective Serotonin Reuptake Inhibitor and Substance P Antagonist Enhancement of Natural Killer Cell Innate Immunity in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome

Cited by 59 publications

References 87 publications

Natural killer cell activity in patients with major depressive disorder treated with escitalopram

Natural killer cell activity in patients with major depressive disorder treated with escitalopram

Neurokinin 1 receptor isoforms and the control of innate immunity

Natural killer cells promote immune tolerance by regulating inflammatory T_H17 cells at the human maternal–fetal interface

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Selective Serotonin Reuptake Inhibitor and Substance P Antagonist Enhancement of Natural Killer Cell Innate Immunity in Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome

Cited by 59 publications

References 87 publications

Natural killer cell activity in patients with major depressive disorder treated with escitalopram

Natural killer cell activity in patients with major depressive disorder treated with escitalopram

Neurokinin 1 receptor isoforms and the control of innate immunity

Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal–fetal interface

Contact Info

Product

Resources

About

Natural killer cells promote immune tolerance by regulating inflammatory T_H17 cells at the human maternal–fetal interface