Depression in Rheumatoid Arthritis

Maldonado, Génessis; Ríos, Carlos; Paredes, Carlos; Ferro, Christian; Intriago, María; Aguirre, Claudia; Ávila, Víctor Daniel; Moreno, Mario

doi:10.1016/j.rcreue.2017.07.001

Cited by 6 publications

(9 citation statements)

References 38 publications

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“…2013). A reduction of 10% in the ability to carry out activities of daily living causes a 7-fold increase in the risk of depression in the following years (Maldonado et al, 2017).This result was in the same line with the study of Mostafa& Radwan. (2013) who revealed that a high positive correlation was found between HADS-D and HAQ scores.…”

Section: Discussionsupporting

confidence: 88%

Symptoms of Depression and Disability among Rheumatoid Arthritis Patients

Mohamed

Abd-Elfatah

Omar

et al. 2020

Minia Scientific Nursing Journal

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Background Rheumatoid arthritis (RA) is a significant and serious public illness affecting peoples especially adults all over the world and emotional problems such as depressive symptoms are more common in patients with RA than in general population. Synovial inflammation, joint damage, degeneration of cartilage, bony destruction and limitation of physical functioning are the distinctive feature of RA that consequently leads to functional disability. This study aimed at assesses prevalence of symptoms of depression and disability among RA patients. Research Design: A descriptive correlational research design was utilized in this study. Study subjects: Established diagnosed 80 RA patients were included in the study. Two tools were used; Beck Depression Inventory (BDI) version I to assess symptoms of depression, and Health assessment questionnaire-disability index (HAQ-DI) to assess disease-related disability. Result: Majority of the participants were females with the age of (20-65) y. About two thirds of the studied sample had moderate depressive symptoms, while about three quarters of them have moderate level of disability. There was significant positive correlation between symptoms of depression and disability. Conclusion: More than three quarters of the studied sample had moderate to severe level of depressive symptoms and disability. Recommendation of the study: Frequent assessments of depressive symptoms and disability in RA patients.

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Section: Discussionsupporting

confidence: 88%

Symptoms of Depression and Disability among Rheumatoid Arthritis Patients

Mohamed

Abd-Elfatah

Omar

et al. 2020

Minia Scientific Nursing Journal

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“…In RA, the cooccurrence is estimated to be 17% [4]. Of note, it has been suggested that these numbers severely underestimate the occurrence of depression due to lack of consistent screening tools and inconsistent application of "gold-standard" interview questionnaires, as evidenced by some individual studies suggesting prevalence rates up to 45% in RA [64]. This contrasts to incidence figures of depression reported in the general population in the US of 7.1% 4 .…”

Section: Discussionmentioning

confidence: 93%

Comparing underlying mechanisms of depression in multiple sclerosis and rheumatoid arthritis

Wenger

Calabrese

2021

Journal of Integrative Neuroscience

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Multiple Sclerosis (MS) and Rheumatoid Arthritis (RA) are common, chronic, autoimmune diseases affecting many people worldwide. While clinically very different in their phenotype, both diseases are thought to have an autoimmune-mediated origin. MS and RA share genetic similarities, and in both diseases, antibodies against host antigens can be found. Aside from the well-known somatic symptoms, many RA patients also show signs and symptoms of psychiatric illnesses, of which depression is the most common diagnosis. In this commentary, both diseases will be introduced and briefly characterized individually and then compared. Depression will be introduced as one of the most frequent psychiatric diseases in the general population. This paper focuses on presenting the possible causes, including psychosocial factors, genetics, and immunologic mechanisms. Hypotheses aimed to explain the higher incidence of depression in these two seemingly different autoimmune diseases will be discussed.

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“…Compared to healthy matched controls, patients with RA are more than twice as likely to develop depression [3,9]. This has important consequences for patient quality of life, as studies have shown that patients with RA and comorbid depression are more likely to be unemployed (30% versus patients with RA without depression symptoms) and that patients with RA and depression generally display higher DAS and levels of functional disability, with disability correlating to the severity of depression [8,18]. Additionally, Timonen et al (2003) found reports of suicidal ideations in 14% of female patients with RA and 3% of male patients with RA in a prospective 13-year cohort study [19].…”

Section: Ra and Depressionmentioning

confidence: 99%

“…While depression is commonly found in patients who suffer from chronic illnesses, it is especially prevalent in the RA population, up to 42% [ 8 , 10 ]. Compared to healthy matched controls, patients with RA are more than twice as likely to develop depression [ 3 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…These systemic inflammatory processes link RA with other inflammatory comorbidities such as cardiovascular disease, malignancy, lung disease, osteoporosis, and neuropsychiatric diseases including depression [3][4]. Due to the expense and side effect profiles of drug regimens for pharmaceutical disease management, [1], and the increasing number of publications addressing the role of nutrition in RA treatment [1,[5][6], and the correlation of RA with depression, [3,[7][8][9][10], the primary objective of this review was to identify and summarize which specific dietary patterns and nutritional interventions go beyond symptom management to improve the response to known inflammatory cytokines and other inflammatory markers in the RA disease process.…”

Section: Introductionmentioning

confidence: 99%

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A Systematic Review of Nutritional Interventions on Key Cytokine Pathways in Rheumatoid Arthritis and Its Implications for Comorbid Depression: Is a More Comprehensive Approach Required?

Lanspa¹,

Kothe²,

Pereira³

et al. 2022

Cureus

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Rheumatoid arthritis (RA) is associated with both local and systemic inflammatory processes via the aberrant regulation of inflammatory pathways and imbalances in several mediators of inflammation. Cytokines, tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1B, IL-6, IL-17, IL-18, rheumatoid factor, anti-cyclic citrullinated protein, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) have been used in diagnosing and tracking the progression of RA. The primary objective of this review is to identify and summarize which specific dietary patterns and nutritional interventions go beyond symptom management to improve the response to known inflammatory cytokines and possibly decrease markers of inflammation in the RA disease process. Analysis of the 41 identified publications demonstrated that certain dietary patterns, the consumption of specific macronutrients, and supplementation with herbals or other compounds have shown some effect on improving cytokine profiles in patients with RA. This review illustrates the importance of proper patient education on the anti-inflammatory and potential protective impacts substantial dietary change may have on the disease progression and symptoms of RA. Identifying nutritional interventions and dietary patterns that improve the inflammatory cytokine profile, and therefore disease progression and inflammatory comorbidities of RA will help further focus research on treatments that may provide a better overall improvement in quality of life for RA patients by focusing on the root cause inflammatory processes that affect not only joint destruction but also depression-rated disability. This review further notes that while depression is commonly found in patients who suffer from chronic illnesses, it is especially prevalent in the RA population. The pathology of depression is associated with systemic inflammation, which is a known outcome of RA and may explain this strong association. Cytokines IL-6, IL-1, and TNF-α, known mediators involved in the progression of RA, are strongly associated with stress-related disorders including depression and anxiety. The presence of these cytokines is also correlated with the severity and duration of depression. This may signal a potential use of cytokines in diagnosing and following the progression of depression not only in patients with RA but also others. Given the statistics presented on depression and suicide in patients with RA, and the shared inflammatory pathway between the two diseases, depression and suicide screening scales should be included along with analysis of inflammatory markers and disease activity scores (DAS) in any future RA study.

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Depression in Rheumatoid Arthritis

Cited by 6 publications

References 38 publications

Symptoms of Depression and Disability among Rheumatoid Arthritis Patients

Symptoms of Depression and Disability among Rheumatoid Arthritis Patients

Comparing underlying mechanisms of depression in multiple sclerosis and rheumatoid arthritis

A Systematic Review of Nutritional Interventions on Key Cytokine Pathways in Rheumatoid Arthritis and Its Implications for Comorbid Depression: Is a More Comprehensive Approach Required?

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