Comparing underlying mechanisms of depression in multiple sclerosis and rheumatoid arthritis

Wenger, Antonia; Calabrese, Pasquale

doi:10.31083/j.jin2003081

Cited by 3 publications

(1 citation statement)

References 57 publications

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“…Depressive disorders are predominantly associated with some chronic inflammatory/autoimmune diseases. This is what happens, for example, in rheumatoid arthritis, where depression represents an important co-morbidity which is more represented, compared to the general population [ 59 ].…”

Section: Correlation Between Depression and Other Psychopathological ...mentioning

confidence: 96%

Neuro-Inflammaging and Psychopathological Distress

et al. 2022

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Inflammaging is a low degree of chronic and systemic tissue inflammation associated with aging, and is intimately linked to pro-inflammatory mediators. These substances are involved in the pathogenesis of chronic inflammatory diseases and related psychopathological symptoms. When inflammation and aging affect the brain, we use the term neuro-inflammaging. In this review, we focused on the neuro-inflammatory process typical of advanced ages and the related psychopathological symptoms, with particular attention to understanding the immune-pathogenetic mechanisms involved and the potential use of immunomodulatory drugs in the control of clinical psychological signs. Inflammation and CNS were demonstrated being intimately linked in the neuro-inflammatory loop. IL-1, IL-6, TNF-a, COX and PGE are only partially responsible. BBB permeability and the consequent oxidative stress resulting from tissue damage make the rest. Some authors elaborated the “theory of cytokine-induced depression”. Inflammation has a crucial role in the onset symptoms of psychopathological diseases as it is capable of altering the metabolism of biogenic monoamines involved in their pathogenesis. In recent years, NSAIDs as an adjunct therapy in the treatment of relevant psychopathological disorders associated with chronic inflammatory conditions demonstrated their efficacy. Additionally, novel molecules have been studied, such as adalimumab, infliximab, and etanercept showing antidepressant and anxiolytic promising results. However, we are only at the beginning of a new era characterized by the use of biological drugs for the treatment of inflammatory and autoimmune diseases, and this paper aims to stimulate future studies in such a direction.

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Section: Correlation Between Depression and Other Psychopathological ...mentioning

confidence: 96%

Neuro-Inflammaging and Psychopathological Distress

et al. 2022

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Tofacitinib Efficacy in Patients with Rheumatoid Arthritis and Probable Depression/Anxiety: Post Hoc Analysis of Phase 3 and 3b/4 Randomized Controlled Trials

Citera,

Jain,

Irazoque

et al. 2023

Rheumatol Ther

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Depression Pathophysiology: Astrocyte Mitochondrial Melatonergic Pathway as Crucial Hub

Anderson¹

2022

IJMS

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Major depressive disorder (MDD) is widely accepted as having a heterogenous pathophysiology involving a complex mixture of systemic and CNS processes. A developmental etiology coupled to genetic and epigenetic risk factors as well as lifestyle and social process influences add further to the complexity. Consequently, antidepressant treatment is generally regarded as open to improvement, undoubtedly as a consequence of inappropriately targeted pathophysiological processes. This article reviews the diverse array of pathophysiological processes linked to MDD, and integrates these within a perspective that emphasizes alterations in mitochondrial function, both centrally and systemically. It is proposed that the long-standing association of MDD with suppressed serotonin availability is reflective of the role of serotonin as a precursor for the mitochondrial melatonergic pathway. Astrocytes, and the astrocyte mitochondrial melatonergic pathway, are highlighted as crucial hubs in the integration of the wide array of biological underpinnings of MDD, including gut dysbiosis and permeability, as well as developmental and social stressors, which can act to suppress the capacity of mitochondria to upregulate the melatonergic pathway, with consequences for oxidant-induced changes in patterned microRNAs and subsequent patterned gene responses. This is placed within a development context, including how social processes, such as discrimination, can physiologically regulate a susceptibility to MDD. Future research directions and treatment implications are derived from this.

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Comparing underlying mechanisms of depression in multiple sclerosis and rheumatoid arthritis

Cited by 3 publications

References 57 publications

Neuro-Inflammaging and Psychopathological Distress

Neuro-Inflammaging and Psychopathological Distress

Tofacitinib Efficacy in Patients with Rheumatoid Arthritis and Probable Depression/Anxiety: Post Hoc Analysis of Phase 3 and 3b/4 Randomized Controlled Trials

Depression Pathophysiology: Astrocyte Mitochondrial Melatonergic Pathway as Crucial Hub

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