Depression in people with epilepsy in West China: Status, risk factors and treatment gap

Li, Qian; Deng, Chao; Zhu, Lina; Wang, Haijiao; Xu, Da; Tan, Ge; Zhang, Yu; Liu, Ling

doi:10.1016/j.seizure.2019.02.014

Cited by 27 publications

(23 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We found in this study that epilepsyrelated factors including age at seizure onset and seizure frequency over the last year were associated with SUA levels in PWE. Similarly, age at seizure onset and seizure frequency have been reported as risk factors for depression in PWE [4,27]. These results may explain the link between SUA levels and depressive symptoms in PWE.…”

Section: Discussionmentioning

confidence: 54%

A cross-sectional study on the association of serum uric acid levels with depressive and anxiety symptoms in people with epilepsy

Zhong

Chen

et al. 2021

BMC Psychiatry

View full text Add to dashboard Cite

Background High serum uric acid (SUA) levels may provide protection against depression and anxiety through its defensive role in oxidative damage. The aim of this study was to test the hypothesis of the independent associations of lower SUA levels with depressive and anxiety symptoms among patients with epilepsy (PWE). Methods A cross-sectional study was performed among 320 PWE aged ≥18 years old in Northeast China. The Neurological Disorders Depression Inventory for Epilepsy (NDDI-E; Chinese version) and the Generalized Anxiety Disorder-7 scale (GAD-7; Chinese version) were used as screening tools for depressive and anxiety symptoms for PWE. Serum uric acid levels were measured. The associations of SUA levels with depressive and anxiety symptoms were assessed by using binary logistic regression models, with adjustment for the related risk factors (P< 0.05). Results Lower SUA tertiles were significantly associated with higher C-NDDI-E and GAD-7 scores compared with the higher two tertiles (p=0.001, and p= 0.002). Patients with depressive symptoms exhibited significantly lower SUA levels compared to those without depressive symptoms (p< 0.001). SUA levels of patients with anxiety symptoms were significantly lower than those of patients without anxiety symptoms (p< 0.001). The first and second SUA tertiles were associated with depressive symptoms, with the third tertile group as the reference group, after adjusting for confounders (first tertile: OR = 4.694, 95% CI = 1.643~ 13.413, P = 0.004; second tertile: OR = 3.440, 95% CI = 1.278~9.256, P = 0.014). However, The first and second SUA tertiles were not associated with the risk of anxiety symptoms compared with the third tertile in the adjusted logistic regression model (First tertile: OR = 1.556, 95% CI = 0.699~3.464, P = 0.279; second tertile: OR = 1.265, 95% CI = 0.607~2.635, P = 0.530). Conclusion We found that lower SUA levels were independently associated with depressive symptoms but not with anxiety symptoms among PWE. Further well-designed prospective cohort studies are required to determine the causality of the associations and to further clarify the mechanisms of SUA in depressive symptoms.

show abstract

Section: Discussionmentioning

confidence: 54%

A cross-sectional study on the association of serum uric acid levels with depressive and anxiety symptoms in people with epilepsy

Zhong

Chen

et al. 2021

BMC Psychiatry

View full text Add to dashboard Cite

show abstract

“…To our knowledge, epilepsy coexisting with psychological disorders, such as depression, is common [12]. Two previous studies in our area have identified a high prevalence of depressive episodes in PWE, based on rapid detection using C-NDDI-E [10,13]. Our findings not only provide information on the mental status of PWE during the epidemic, but also contribute to the understanding of the risk factors associated with depression.…”

Section: Discussionmentioning

confidence: 56%

Depression in patients with epilepsy during the COVID‐19 pandemic based on longitudinal self‐reporting

Sun¹,

Mo²,

Sun³

et al. 2021

Epileptic Disorders

View full text Add to dashboard Cite

Objective. The current study screened major depression in people with epilepsy (PWE) during the epidemic of the novel coronavirus-related disease COVID-19, in order to identify whether the outbreak generated negative psychological impact on PWE. Methods. A Chinese version of the Neurological Disorders Depression Inventory for Epilepsy (C-NDDI-E), a self-reporting depression inventory, was applied for rapid detection of major depression. Assessment was carried out online during three different periods (prior to, during, and after the outbreak of COVID-19), with the aim of identifying changes in prevalence of depression and associated risk factors. Results. A total of 158 PWE were recruited into the study (48.7% female). The questionnaire completion rates were 94.3% and 70.9% during and after the outbreak, respectively. The prevalence of depression prior to the epidemic, as the baseline, was 34.8% and increased to 42.3% during the period of the epidemic. Towards the end of the outbreak, the prevalence declined towards the baseline (36.6%). Factors such as living alone (OR = 4.022, 95% CI: 1.158-13.971, P = 0.028) and active seizures before the epidemic (OR = 2.993, 95% CI: 1.197-7.486, P = 0.019) were associated with depression during the epidemic. Monotherapy appeared to be protective against depression (OR = 0. 105, 95% CI: 0.047-0.235, P <0.001). Significance. Our results suggest that the pandemic exerts negative influence on PWE's mental health. Depression is one of the common psychological disorders that needs greater attention during this extraordinary period.

show abstract

“…Epilepsy is also associated with multiple co-morbidities and neuropsychiatric problems. Depression in particular has been reported in a sizable proportion of PWE [7] , [8] , [9] , [10] and a bidirectional relationship between epilepsy and depression is suggested [11] . While many studies over the past one year have reported an increase in seizure frequency in PWE [3] , [12] , [13] , [14] , [15] , [16] , [17] , [18] , however, to the best of our knowledge studies assessing the impact on depression in PWE are scarce.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of depression and suicidal ideation in persons with epilepsy during the COVID-19 pandemic: A longitudinal study from India

Katyal

Rashid

Tripathi

et al. 2021

Epilepsy & Behavior

View full text Add to dashboard Cite

Objectives COVID-19 pandemic has disrupted healthcare services for chronic disorders such as epilepsy. In this study, the impact of COVID-19 pandemic on persons with epilepsy (PWE) with regard to their seizure control, depression status, and medication adherence was assessed. Methods After ethical clearance, 449 PWE who had been previously evaluated for depression at All India Institute of Medical Sciences (AIIMS), New Delhi, India, were telephonically revaluated using Mini International Neuropsychiatric Interview and surveyed for source of medication and medication adherence over last 6 months. The prevalence and the association of depression, suicidality and seizures during pandemic with different PWE variables were determined. Results Out of 449 PWE, 70.6% responded. 19.9% were diagnosed positive for depression as per MINI while suicidal ideation was observed in 5.4%. Seventy six (23.9%) PWE reported seizures during pandemic. The incidence being greater in females, unemployed, previously uncontrolled epilepsy, polytherapy, altered use of medications and depressed PWE. Seizure during pandemic, increased seizure frequency, previous history of depression and altered use of medications were all significantly associated with depression during COVID-19 pandemic (2.6- 95%CI, 1.45–4.73; 1.9- 95%CI, 1.01–3.57; 8.8- 95%CI, 4.54–17.21; 2.9- 95%CI, 1.19–7.24), and polytherapy (2.9- 95%CI, 0.92–9.04), seizures during pandemic (3.9- 95%CI, 1.45–10.53) and previous history of depression and suicidality, were related with suicidal ideation. Conclusion COVID-19 pandemic induced disruptions can be detrimental for PWE and restoring services to the precovid levels as well as putting appropriate continuity plans in place for care of PWE should be a priority.

show abstract

Depression in people with epilepsy in West China: Status, risk factors and treatment gap

Cited by 27 publications

References 56 publications

A cross-sectional study on the association of serum uric acid levels with depressive and anxiety symptoms in people with epilepsy

A cross-sectional study on the association of serum uric acid levels with depressive and anxiety symptoms in people with epilepsy

Depression in patients with epilepsy during the COVID‐19 pandemic based on longitudinal self‐reporting

Prevalence of depression and suicidal ideation in persons with epilepsy during the COVID-19 pandemic: A longitudinal study from India

Contact Info

Product

Resources

About