Depression and Quality of Life in Psoriasis

Voorhees, Abby S. Van; Fried, Richard G.

doi:10.3810/pgm.2009.07.2040

Cited by 65 publications

(62 citation statements)

References 69 publications

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“…Psoriasis is a chronic skin disorder characterized by scaly, itchy and painful skin lesions. Studies have demonstrated that patients with psoriasis have a reduced HRQL, and display psychological issues such as depression (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Patient-reported impact of chronic urticaria compared with psoriasis in theUnited States

Mendelson

Bernstein

Gabriel

et al. 2016

Journal of Dermatological Treatment

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Purpose: Data are lacking on the burden of chronic idiopathic urticaria (CIU) versus other dermatologic conditions. This analysis compared the burden of chronic urticaria (CU, proxy for CIU) with psoriasis. Methods: Data from CU (N ¼ 747) and psoriasis patients (N ¼ 5107) came from 2010 to 2012 US National Health and Wellness Surveys. Outcomes included SF-12v2/SF-36v2 mental and physical component summary scores (MCS and PCS, respectively) and other health/activity-related measures. Results: MCS score was 44.7 for CU, and 48.2, 44.7 and 44.3 for mild/moderate/severe psoriasis, respectively (US norm ¼ 50). PCS score was 43.8 for CU, and 46.5, 44.1 and 40.3 for mild/moderate/severe psoriasis. Health utility score was 0.67 for CU, and 0.72, 0.67 and 0.65 for mild/moderate/severe psoriasis. More CU patients reported depression (39%), anxiety (42%) and sleep difficulties (50%) than psoriasis patients (any severity). Overall work impairment was 29% for CU, and 19%, 26% and 31% for mild/moderate/severe psoriasis. Activities impairment was 39% for CU, and 28%, 37% and 43% for mild/moderate/severe psoriasis. CU and psoriasis patients had frequent healthcare visits. Conclusions: Patients with CU had impaired mental/physical health and work/non-work activities, similar to moderate-to-severe psoriasis patients. Results suggest that better disease management of CU is needed. This analysis should also reflect the significant burden of CIU. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Patient-reported impact of chronic urticaria compared with psoriasis in theUnited States

Mendelson

Bernstein

Gabriel

et al. 2016

Journal of Dermatological Treatment

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“…Abnormal IL-17 expression has also been observed in psoriatic patients with therapeutic inhibition showing success in reducing disease severity [35,36]. Furthermore, as has been discussed above, inflammatory cytokines like TNF-α, IFN-γ, and other type-1 cytokines play a crucial part in the pathophysiology of psoriasis [26]. …”

Section: Immunological Changes In Psoriasismentioning

confidence: 99%

“…In fact in two studies done by Gupta et al [18,19], an increase in stress and depressive symptoms were found to have a significant statistical correlation with an increase in psoriasis flare-ups and pruritus severity along with a more clinically disfiguring disease. In addition, studies have shown that a decrease in depression/depressive symptoms due to medication or therapy is associated with a decrease in psoriasis severity and vice versa [20,21,22,23,24,25,26]. The question now remains: is this correlation merely due to the negative psychological effects inherent in any clearly discernible skin disorder, or any disorder in general, such as social anxiety, low self-esteem, shame/embarrassment etc., or is there an underlying pathophysiological mechanism involved?…”

Section: Depression and Psoriasis: A Psychodermatological Associationmentioning

confidence: 99%

Major Depression and Psoriasis: A Psychodermatological Phenomenon

Tohid¹,

Aleem²,

Jackson³

2016

Skin Pharmacol Physiol

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Objective: The aim of this paper was to highlight the mechanisms involved and the relationship between depression and psoriasis. Method: A comprehensive literature search was performed in various databases, and finally 88 studies were deemed relevant. Results: A significant link was found between depression and psoriasis, primarily through immune mechanisms related but not limited to the actions of inflammatory cytokines such as tumor necrosis factor-α, interleukin 1 (IL-1), IL-2, IL-10, interferon-γ, IL-1β, prostaglandin E2, C-reactive protein, IL-6, and IL-8. Conclusion: Various neuroimmunological studies point towards the notion that depression and psoriasis are associated with each other. Melatonin has also been found to be associated with both conditions. A possibility exists that both conditions can cause each other due to the possible bidirectional relationship of psoriasis and major depression. However, if this is the case, then why all depressed patients fail to develop psoriasis and why all psoriatic patients fail to develop depression remains a question unanswered. We believe that future studies will unmask this mystery.

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“…Anyway, relatively high rates of depression are reported in patients with psoriasis [54,55]. Controlled studies found notably higher degree of depression in patients with psoriasis than in controls [56][57][58].…”

Section: Psoriatic Arthritismentioning

confidence: 99%