Major Depression and Psoriasis: A Psychodermatological Phenomenon

Tohid, Hassaan; Aleem, Daniyal; Jackson, Chantal

doi:10.1159/000448122

Cited by 52 publications

(55 citation statements)

References 80 publications

(88 reference statements)

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“…Firstly and strictly taken, the cross-sectional design of this study does not allow a causal relationship between the presence of LPP and psychological issues such as symptoms of depression and anxiety. However, unlike for instance psoriasis [24, 25], LPP does not appear to be considered a psycho-dermatological and therefore psychosomatic issue [26, 27]; accordingly, we assume that the appearance of signs of LPP negatively impact individuals’ psychological well-being, and not vice versa. Secondly, no further objective data such as blood markers or psychophysiological data were assessed.…”

Section: Discussionmentioning

confidence: 99%

Compared to Controls, Individuals with Lichen Planopilaris Have More Depression, a Lower Self-Esteem, and a Lower Quality of Life

et al. 2019

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Background: Individuals with lichen planopilaris (LPP) typically present with hair loss and an irritated scalp, with signs and symptoms such as itching, erythema, scaling, and burning. Both hair loss and reddened skin may be visible also for other people. Therefore, it is conceivable that individuals with LPP might report a lower mental health status. Accordingly, in the present study, we compared dimensions of mental health between individuals with LPP and healthy controls. Method: A total of 38 individuals with LPP (mean age: 38.24 years, 47.4% females) and 58 gender- and age-matched controls took part in this study. They completed questionnaires covering dimensions of quality of life and self-esteem; experts rated participants’ symptoms of depression and anxiety. Furthermore, dermatologists reported on the illness duration, the LPP activity index, and the severity of alopecia. Results: Compared to healthy controls, individuals with LPP reported lower scores of self-esteem, physical functioning, and mental health and higher scores of role limitations (physical and emotional). Likewise, experts rated higher depression scores in individuals with LPP compared to controls. In individuals with LPP, a higher LPP disease activity and a higher severity of hair loss were associated with higher depression and lower quality-of-life scores. Further, a higher LPP activity index, a lower self-esteem, and higher anxiety scores predicted a poorer quality of life, while illness duration was statistically unrelated. Conclusions: Compared to controls, and irrespectively of the illness duration, individuals with LPP reported a lower quality of life and a lower self-esteem, and experts’ ratings observed higher scores of depression. Experts treating individuals with LPP might pay special attention to the individuals’ mental health status.

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Section: Discussionmentioning

confidence: 99%

Compared to Controls, Individuals with Lichen Planopilaris Have More Depression, a Lower Self-Esteem, and a Lower Quality of Life

et al. 2019

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“…Bei Ps wurden in einer Arbeit von Esposito et al (n = 2391) bei 62% der Patienten depressive Symptome festgestellt;interessanterweise korrelierte in einer weiteren Arbeit der «Psoriasis Area and Severity Index»(PASI)-Wert mit dem Schweregrad der Depression [1]. 31% der Patienten mit AD in den USA berichteten über mindestens ein depressives Symptom [2].…”

Section: Transfer In Die Praxis Von Dr Sandra Philipp (Oranienburg)unclassified

“…Auch beobachtet man eine Verschlechterung der dermatologischen Erkrankungen bei psychologischem Stress. Ist diese Assoziation nur durch die negativen psychologischen Effekte der Hauterkrankung wie soziale Ängste und Scham erklärbar oder gibt es einen zugrunde liegenden pathophysiologischen Mechanismus [1]? Inzwischen gilt es als gesichert, dass jede der aufgeführten Erkrankungen eine bestimmte Zytokinsignatur aufweist.…”

Section: Transfer In Die Praxis Von Dr Sandra Philipp (Oranienburg)unclassified

Chronisch-entzündliche Hauterkrankungen und psychische Erkrankungen - Zusammenhänge beachten und daran denken

Philipp¹

2019

Kompass Dermatol

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The prevalence of affective disorders such as depression and anxiety is particularly high in patients with autoimmune diseases, including inflammatory skin diseases such as psoriasis, atopic dermatitis, and hidradenitis suppurativa. A dysregulated immune response has been linked to the precipitation of depression in many patient populations. However, studies examining the extent to which the underlying skin disease inflammatory processes contribute to depression and a subsequent decline in quality of life are limited. The published literature over the past 5 years was reviewed for evidence of a relationship between depression and inflammatory processes in the context of skin pathology. The findings, particularly the evidence from interventional clinical trials of targeted anti-cytokine therapies, suggest that proinflammatory cytokines associated with several skin diseases may be causally linked with the coexistent depressive symptomology.

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“…In Germany alone, about 2 million people are affected by this condition. For the affected subjects, psoriasis often entails a considerable stigma as well as restrictions with regard to their quality of life and their physical and mental health [2,3]. The annual health care costs are substantial.…”

Section: Introductionmentioning

confidence: 99%

Application of Photoacoustic Methods and Confocal Microscopy for Monitoring of Therapeutic Response in Plaque Psoriasis

Ossadnik

Philipp

Bost

et al. 2018

Skin Pharmacol Physiol

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Psoriasis is prone to relapses and requires long-term therapy that may induce a range of adverse effects; therefore, an efficient and early detection of relapses is desirable. In this study, photoacoustic imaging and confocal laser scanning microscopic (CLSM) methods were investigated for their suitability in psoriasis follow-up examinations. Using a high-resolution photoacoustic system, the vascular structures of 11 psoriatic patients and 6 healthy volunteers were investigated. No differences were detected with respect to the average vessel diameter and vasculature per unit volume in the tissue of healthy volunteers and non-lesional and lesional skin areas of psoriatic patients. By means of CLSM, the diameters of the dermal papillae of 6 volunteers and 6 psoriatic patients were determined. The diameters of the dermal papillae of the healthy volunteers (0.074 ± 0.006 mm) revealed no significant difference when compared to non-lesional skin areas of psoriatic patients (0.079 ± 0.005 mm). The results obtained for the lesions in psoriatic patients showed a significant difference (Wilcoxon test, p = 0.028) between the diameters of the dermal papillae of the lesional skin areas (0.114 ± 0.012 mm) and the non-lesional skin areas (0.079 ± 0.005 mm). Thus, CLSM can be applied for monitoring psoriasis follow-up examinations.

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Major Depression and Psoriasis: A Psychodermatological Phenomenon

Cited by 52 publications

References 80 publications

Compared to Controls, Individuals with Lichen Planopilaris Have More Depression, a Lower Self-Esteem, and a Lower Quality of Life

Compared to Controls, Individuals with Lichen Planopilaris Have More Depression, a Lower Self-Esteem, and a Lower Quality of Life

Chronisch-entzündliche Hauterkrankungen und psychische Erkrankungen - Zusammenhänge beachten und daran denken

Application of Photoacoustic Methods and Confocal Microscopy for Monitoring of Therapeutic Response in Plaque Psoriasis

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