Depression and quality of life in children with sickle cell disease: the effect of social support

Abstract

BackgroundThe majority of available studies have shown that children with sickle cell disease (SCD) have a higher risk of depressive symptoms than those without. The present study aimed to: assess the prevalence of depression in a sample of children with SCD; evaluate the association between disease severity, social support and depression, and the combined and/or singular effect on health-related quality of life (HRQL) in children with SCD; and show the predictive value of social support and disease severity on depression.MethodsA total of 120 children were included in the study, 60 (group I) with SCD and 60 matched, healthy control children (group II). Depression was assessed in both groups using the Children’s Depression Inventory (CDI) and the Children’s Depression Inventory-Parent (CDI-P). Children with CDI and CDI-P scores of more than 12 were interviewed for further assessment of depression using the Diagnostic Interview Schedule for Children Version IV (DISC-IV). The Pediatric Quality of Life Inventory Version 4.0 Generic Core Scales (PedsQL 4.0) was used to assess HRQL in both groups, and social support was measured with the Child and Adolescent Social Support Scale (CASSS).ResultsEight (13%) of the 60 children with SCD had CDI and CDI-P scores of more than 12 (CDI mean score 14.50 ± 1.19, CDI-P mean score 14.13 ± 1.12), and were diagnosed as having clinical depression using the diagnostic interview DISC-IV. For group I, HRQL was poor across all PedsQL 4.0 domains in both self- and parent-reports (P < 0.001) compared with group II. A higher level of parent support was a significantly associated with decreased depressive symptoms, demonstrated by lower CDI scores. Better quality of life was shown by the associated higher total PedsQL 4.0 self-scores of children with SCD (B = −1.79, P = 0.01 and B = 1.89, P = 0.02 respectively).ConclusionsThe present study demonstrates that higher levels of parent support were significantly associated with decreased depressive symptoms and better quality of life in children with SCD. Interventions focused on increasing parent support may be an important part of treatment for depression in children with SCD.

Effectiveness of Nurse Led Intervention on Health Related Quality of Life among Children with Sickle Cell Disease in Oman: A Pilot Study

“…However, some dimensions of HRQOL scores such as pain impact, emotions and communication I & II did not show any signi cant improvement. Studies have shown that the children with SCD have poor psychological health and lack of family interaction which remains one of the most common problems due to frequent pain crisis, lack of knowledge of the disease and disrupted family relationships [16,31,32]. Similar to these study results, this study also identi ed that the children with SCD had poor psychological function and communication before nurse led intervention.…”

Neurocognitive and psychological effects of persistent pain in pediatric sickle cell disease

“…Youth with SCD are at risk for emotional, academic, and neurocognitive difficulties. [6][7][8] Such impairments are perhaps most clearly evidenced in reports of lower health-related quality of life (HRQL) related to both physical and psychosocial functioning. 9 Caregivers and teachers are more likely to rate youth with SCD as having symptoms of internalizing problems (eg, depression, anxiety) and social challenges in comparison to healthy peers and siblings.…”

“…Youth with SCD are at risk for emotional, academic, and neurocognitive difficulties . Such impairments are perhaps most clearly evidenced in reports of lower health‐related quality of life (HRQL) related to both physical and psychosocial functioning .…”

Apoio social e o cuidado integral à saúde do idoso

“…A falta de rede social é preditora de mortalidade por diversas causas (HOBBS et al, 2016;ZUNZUNEGUI et al, 2004). Relatos de melhoria de parâmetros médicos, como saúde mental (LADITKA et al, 2009), depressão (SEHLO;KAMFAR, 2015;MARQUES et al, 2013;BAPTISTA;BAPTISTA;TORRES, 2006;CHI;CHOU, 2001;MUI, 1996), incapacidades (JAMES et al, 2011), parâmetros sociais como prevenção à institucionalização (RODRIGUES;SILVA, 2013;KRISTJANSSON;BREITHAUPT;McDOWELL, 2001;BARKER, 2002) e parâmetros de saúde como bem-estar (PAZIN et al, 2016;KUTEK;TURNBULL;FAIRWEATHER-SCHMIDT, 2011;KENDIG;BROOKE, 1997) e qualidade de vida (FERNANDEZ-MAYORALAS et al, 2012;BARKER;MORROW;MITTENESS, 1998) estão entre os mais estudados e reforçam o quanto uma rede social adequada em sua extensão e qualidade de relações alicerçam o suporte em nível emocional, instrumental, informacional e cognitivo (GONÇALVES et al, 2011;FONTES, 2004).…”