Sickle cell disease (SCD) can significantly impair the health-related quality of life (HRQOL) of children and adolescents. This review aimed to assess current evidence regarding the HRQOL of children and adolescents with SCD in the Middle East and North Africa region. A systematic search of various databases was conducted to identify relevant articles, including MEDLINE® (National Library of Medicine, Bethesda, Maryland, USA), Scopus® (Elsevier, Amsterdam, the Netherlands), Cumulative Index to Nursing and Allied Health Literature®, Masader (Oman Virtual Science Library, Muscat, Oman) and EBSCOhost (EBSCO Information Services, Ipswich, Massachusetts, USA). A total of 533 articles were identified; however, only 10 were eligible for inclusion in the final analysis. Results from these studies showed that children and adolescents with SCD had compromised HRQOL compared to their healthy peers, particularly in terms of physical, psychosocial, familial, financial and academic functioning. Therefore, interventions are necessary to improve overall HRQOL outcomes for this population. Keywords: Sickle Cell Disease; Health-Related Quality Of Life; Infants; Children; Adolescents; Middle East; North Africa.

Objective An acute shortage of nurses exists all over the world. Part of this shortage appears to be due to nurses’ low job satisfaction, low retention, and high turnover. Happiness at work is identified as a contributing factor that determines the shortage of nurses across the world. This paper critically appraised the existing scientific articles that assessed the individual and organizational predictors of happiness among nurses. Methods The systematic review was conducted from August 2010 to August 2020 using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Scientific articles were searched in the electronic databases (Scopus, Medline, CINAHL, PsychINFO, and Pubmed Central) on the predictors of happiness among nurses. Results A total of 13 articles were selected following the literature search and a thematic analysis was done. This review provides updated evidence on the predictors of nurses’ happiness. Job-related predictors were identified as organizational predictors; and personal, psychological, family, social, and spiritual predictors were reported to be the individual predictors. Conclusions As both individual and organizational predictors determine the happiness of nurses, the authors recommend the need for future interventional studies to increase the nurses’ happiness, their mental health, and health-related quality of life.

Introduction. The children with Sickle Cell Disease (SCD) generally have poor Health Related Quality of Life (HRQOL). The study aimed to evaluate the effectiveness of nurse led intervention on HRQOL among children with SCD. Methods. A total of 30 samples were selected using convenient sampling. Children with SCD and their caregivers completed Pediatric Quality of Life Inventory (PedsQL) SCD-Module version 3.0. The nurse led intervention was given to the study group for 10 consecutive weeks. The control group received the routine medical care. On completion of 10 weeks, the post-test was conducted. Results. The participants in study group had poor HRQOL scores P>0.05 in pre-test. After nurse led intervention, the HRQOL score in the study group significantly improved P<0.05. The control group did not show any significant difference in the pretest and post-test. Discussion. Therefore nurse led intervention is effective in improving HRQOL among children with SCD.

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