Depressed Brainstem Auditory Function in Children With Cerebral Palsy

Abstract

Brainstem auditory evoked responses were studied to examine brainstem auditory function in 80 children with cerebral palsy. The response waveform, particularly later waves, tended to be depressed. Thirty-three (41.3%) showed abnormal results. The main abnormality was reduced wave V amplitude. Other abnormalities were decreased V/I amplitude ratio, missing waves, prolonged I-V interval, and increased interaural difference in I-V interval. The abnormalities were persistent during the follow-up. In contrast to common findings in the responses in progressive neurologies, abnormalities in interpeak intervals were rare in children with cerebral palsy. There were some characteristic changes in the responses in certain etiologies. These results suggest that brainstem auditory function in children with cerebral palsy is depressed, which may be owing to decreased or altered neural firing or synchrony in the auditory brainstem. A detailed analysis of central components of the responses is valuable in detecting central auditory dysfunction in children with cerebral palsy.

OPA1-related auditory neuropathy: site of lesion and outcome of cochlear implantation

“…Cochlear potentials recorded from OPA1 -M patients were compared to ECochG data previously collected from children tested for presumed cochlear deafness. Bilateral transtympanic recording methods are part of our audiological evaluation of hearing disorders in children when the reliability of ABRs in hearing threshold estimation could be significantly reduced, possibly resulting from dysfunction or immaturity of brainstem generators of ABRs ( Kraus et al , 1984 ; Jiang et al , 2008 , 2011 ). Approximately 350 children have been tested by transtympanic ECochG at our department over the past 15 years.…”

Shaking Table Test on Dynamic Response of Bedding Rock Slopes With Weak Structural Plane Under Earthquake

“…The geological survey report shows that the lithology of the prototype slope is mainly quartz sandstone splint. Referring to the types of raw materials commonly used in model test and their mechanical properties [25,26], gypsum, clay, river sand, and water are used as raw materials of similar materials in this test. Through repeated material ratio test, it is determined that the ratio of the simulated rock material is gypsum: clay: river sand: water 1: 5.38: 1.52: 0.27, and the ratio of the weak structure plane simulated material is clay: river Sand: water 1: 6.89: 0.25.…”

Characteristics of short-patent auditory evoked potentials in children with cerebral palsy

“…Зарубежные исследования имеют неоднозначные выводы относительно природы стволовой дисфункции у детей с ЦП. При оценке АСВП у 80 детей в возрасте 3-12 лет в ряде случаев регистрировалось выпадение отдельных пиков, удлинение межпиковой латентности N 1 -N 5 и редукция высоты N 5 пика у детей с тяжелой асфиксией в анамнезе, что в совокупности отражает дизафферентацию преимущественно за счет межъядерной десинхронизации на уровне ствола головного мозга при сохранной миелинизации проводникового отдела анализатора у большинства пациентов с ЦП [17]. В то же время анализ параметров АСВП у 50 детей в возрасте от 4 мес до 10 лет выявил сочетанное статистически значимое увеличение как латентности основных пиков, так и межпиковых латентностей по сравнению с показателями контрольной группы, что говорит о смешанном патогенезе нарушения акустической афферентации [18].…”