Depigmentation therapy in vitiligo universalis with topical 4-methoxyphenol and the Q-switched ruby laser

Njoo, M. D.; Vodegel, R.M.; Westerhof, W.

doi:10.1067/mjd.2000.103813

Cited by 155 publications

(93 citation statements)

References 21 publications

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“…163,164,167 Conjunctival melanosis, pingueculae, and corneal pigment deposition have been reported with monobenzone. 168 …”

Section: Safetymentioning

confidence: 95%

“…163 In a study with hydroquinone, 69% achieved total depigmentation; however, 36% of those had some repigmentation at 2 months to 3 years of follow-up. 164 The Q-switched ruby laser has been extensively used for depigmentation in vitiligo universalis, although the Q-switched alexandrite laser is also effective. 165 Njoo et al 164 showed that combining hydroquinone and the Q-switched ruby laser results in complete depigmentation in 69% of patients; however, 44% had repigmentation 2 to 18 months posttreatment.…”

Section: Introductionmentioning

confidence: 99%

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Vitiligo: A comprehensive overview

Felsten

Alikhan

Petronic‐Rosic

2011

Journal of the American Academy of Dermatology

151

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“…163,164,167 Conjunctival melanosis, pingueculae, and corneal pigment deposition have been reported with monobenzone. 168 …”

Section: Safetymentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Vitiligo: A comprehensive overview

Felsten

Alikhan

Petronic‐Rosic

2011

Journal of the American Academy of Dermatology

151

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“…Following this clue, several research workers did advance studies in this field and obtained astonishing results. However, the success rates were variable and ranged from 22% to 72% (13,166,195,196). Nevertheless, the advantage of only a small piece of donor skin providing a large number of pure autologus melanocytes made it a treatment of choice for extensive disease requiring surgery.…”

Section: Cultured Melanocyte Suspension 'Grafting'mentioning

confidence: 97%

“…Specifically, good nutrition, a building up of general health, the elimination of suspected underlying causative factor(s), along with suppression of depigmentation and stimulation of repigmentation by various agents (8). Surgical interventions form an ultimate option in recalcitrant non-progressive vitiligo (9)(10)(11) (Table I), whereas, in situations where the lesions are extensive, progressive and intractable, and it is not possible to induce repigmentation, depigmentary agents could be a feasible option for the remaining 'islands' of normal skin after ensuring due consent (12)(13)(14). There has been recent renewed interest in vitiligo therapy (15) because of the introduction of newer immunosuppressive drugs such as tacrolimus (16) and improved surgical procedures (17).…”

Section: Introductionmentioning

confidence: 99%

Vitiligo treatment options: An evolving scenario

Sehgal¹,

Srivastava²

2006

Journal of Dermatological Treatment

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Sequential displays of several treatment options for vitiligo have been scanned from the literature, and are presented here. A few of the medical modalities have been resigned to history, whereas others have become customary in clinical practice. There has also been a recent surge of interest in the surgical treatment of this disease. Accordingly, this has been appraised and summarized. Special attention has been given to prevalent medical modalities so that they may be effectively utilized by those currently in practice.

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“…Dört-metoksifenol de MBEH gibi melanotoksiktir. Her iki tedavi de Q-switched ruby lazer ve kriyoterapi ile kombine kullan labilir (21,22).…”

Section: Depigmentasyonunclassified

Treatment of Vitiligo and New Treatment Approaches

Demirel¹,

Borlu²

2010

Turk J Dermatol

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ÖzetVitiligo, melanositlerin sayı ve işlev kaybı ile karakterize bir pigment hastalığıdır. Etyolojisi bilinmemektedir ancak otoimmun, genetik, biyokimyasal faktörler ve nöral mekanizmalar etyolojide suçlanmaktadır. Melanosit antijenlerini hedef alan sitotoksik T hücrelerinin varlığı ve sitokin seviyelerindeki dengesizliğin melanosit hasarına ve ölümüne neden olduğu düşünülmektedir. Vitiligo tedavisi lezyonların yaygınlığına, lokalizasyonuna, yaşa ve önceki tedavilere verilen yanıta göre değişmektedir. Bu derlemede vitiligo tedavisi geleneksel tedaviler, yeni tedavi seçenekleri, cerrahi tedaviler, deneysel ve diğer tedavi seçenekleri başlıkları altında ele alınmış ve güncel literatür bilgileri ışığında değerlendirilmiştir. (Turk J Dermatol 2010; 4: 33-9 AbstractVitiligo is an pigmentary disorder characterized by loss of functional melanocytes. Altough the aetiology is unknown, autoimmunity, genetic factors, biochemical factors and neural mechanisms were suspected. Cytotoxic T cells targeting melanocyte antigens are present and also an imbalance of the cytokine levels leading to melanocyte damage and death. It is believed that the treatment of vitiligo differs according to the severity of disease, localisation, age and response to previous medications. In this article we reviewed the current literature about vitiligo and classified the treatment options of vitiligo as traditional and current treatment options, surgical treatments, experimental therapies and other treatment options. (Turk J Dermatol 2010; 4: 33-9)

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Depigmentation therapy in vitiligo universalis with topical 4-methoxyphenol and the Q-switched ruby laser

Cited by 155 publications

References 21 publications

Vitiligo: A comprehensive overview

Vitiligo: A comprehensive overview

Vitiligo treatment options: An evolving scenario

Treatment of Vitiligo and New Treatment Approaches

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