Vitiligo treatment options: An evolving scenario

Abstract

Sequential displays of several treatment options for vitiligo have been scanned from the literature, and are presented here. A few of the medical modalities have been resigned to history, whereas others have become customary in clinical practice. There has also been a recent surge of interest in the surgical treatment of this disease. Accordingly, this has been appraised and summarized. Special attention has been given to prevalent medical modalities so that they may be effectively utilized by those currently in practice.

Repigmentation by Outer-Root-Sheath-Derived Melanocytes: Proof of Concept in Vitiligo and Leucoderma

“…Autologous melanocyte transplantation is an option in case of disfiguring, stable vitiligo, but the optimal modality is still debated. So far, the focus has been on procedures of isolation, application and eventually cultivation using interfollicular epidermal melanocytes harvested by skin biopsy from the patient [for reviews, see [1,2,3,4,5,6]]. As for keratinocytes, a stem cell pool resides in the outer root sheath (ORS) of hair follicles also for melanocytes [7], illustrated clinically by the well-known phenomenon of follicular repigmentation in spontaneously healing vitiligo.…”

A Traditional Review of the Role of Vitamin D in Vitiligo

“…1,3 Yaygın bir hastalık olan vitiligo için farklı tedavi yöntemleri olmasına rağmen bütün hastalar için faydalı, tam olarak iyileşme sağlayan, etiyolojisinde rol oynayan faktörler üzerinde etkili bir ilaç olmayıp, tedaviye yanıt kişiden kişiye değişiklik göstermektedir. 4 Vitiligo lekelerinde, kalsiyum (Ca) dengesindeki bozulmanın nedensel bir faktör olabileceği düşünüldüğünden, hastalığın tedavisinde D vitamini analoglarının etkisi araştırılmıştır. 5 Bu derlemede D vitamininin, cilt pigmentasyonundaki rolü ve vitiligo hastalığıyla ilişkisi incelenmiştir.…”