Dependence of the biodegradability of carboxymethylcellulose on its supermolecular structure and molecular parameters

A docetaxel-carboxymethylcellulose nanoparticle outperforms the approved taxane nanoformulation, Abraxane, in mouse tumor models with significant control of metastases

“…We selected carboxymethylcellulose (CMC) as a structural molecule, based on CMC's high degree of substitution of carboxylic acids for drug incorporation, commercial availability, its known biocompatibility in medicine and food, and FDA approval in parenteral formulations such as Vivitrol and Sandostatin [38]. CMC is known to be degradable and fully bioeliminable [39]: cellulosic breakdown occurs via oxidative and hydrolytic scission of the sugar linkages via macrophage degradation [40,41].…”

A review of the composition, characteristics, and effectiveness of barrier mesh prostheses utilized for laparoscopic ventral hernia repair

“…HA molecules can enter the lymphatic system and be broken down into both high and low molecular weight byproducts, which enter the bloodstream and are metabolized by the liver [21]. CMC is a derivative of cellulose, which is enzymatically hydrolyzed, metabolized by macrophages, and finally excreted [22]. The plasticizer, PEG, is absorbed by the lymphatic system, circulated in the blood, and finally cleared through the kidneys [23].…”

A randomized, prospective, blinded, split‐face, single‐center study comparing polycaprolactone to hyaluronic acid for treatment of nasolabial folds

“…The PCL microspheres (25–50 μm) are suspended in an aqueous carboxymethylcellulose (CMC) gel carrier. Both PCL and CMC individually have an excellent and proven biocompatibility profile and have been used successfully in numerous CE‐marked and FDA‐approved medical devices such as oral and maxillofacial surgery, wound dressing, and controlled drug delivery systems . In a recent study, the excellent biocompatibility profile of PCL has been extended by showing its use as a bioresorbable tracheal splint for the treatment of tracheobronchomalacia, an airway disease .…”