A randomized, prospective, blinded, split‐face, single‐center study comparing polycaprolactone to hyaluronic acid for treatment of nasolabial folds

Abstract

Our results suggest that PCL-based dermal fillers offer longer-lasting performance over NASHA-based dermal fillers in NLFs treatment.

Ultrasound Morphology of Polycaprolactone Filler

“…In contrast to clinical reports that mention that the deposits of polycaprolactone are located in the dermis, we found this filler primarily in the hypodermis in all patients. This coincides with previous reports that demonstrate the sonographic presence of common types of cosmetic fillers in the hypodermis .…”

“…It may be important to know this sonographic morphology for assessing the location and duration of polycaprolactone under real‐world conditions. So far, this filler has been suggested to be reabsorbed in up to 4 years; however, to date it is unclear whether this potential reabsorption takes place in all components of the filler (microspheres and hydrogel) or only in its hydrogel part. Thus, this process can be monitored by a noninvasive imaging technique with a wide field of view such as ultrasound.…”

“…Polycaprolactone is a cosmetic filler consisting of 25 to 50 microspheres and a carboxymethylcellulose hydrogel . It has been used widely for treating wrinkles and for soft tissue augmentation of the face and hands .…”

The efficacy of powdered polydioxanone in terms of collagen production compared with poly‐L‐lactic acid in a murine model

“…Recently, one comparative study suggested that these biostimulatory dermal fillers, such as PCL, are more effective than HA filler for nasolabial fold treatment. Therefore, many high molecular weight polymer‐containing fillers that have biostimulatory effects appear continuously today …”

“…Therefore, many high molecular weight polymer-containing fillers that have biostimulatory effects appear continuously today. 9 Poly-L-lactic acid has biostimulatory effects through macrophages, (myo-)fibroblasts, and collagen that orchestrate capsule formation. The reaction starts with subclinical inflammation that continues to microparticle encapsulation and then to collagen production by the host.…”