The efficacy of powdered polydioxanone in terms of collagen production compared with poly‐L‐lactic acid in a murine model

Abstract

Summary Background There are many collagen‐stimulating fillers, including calcium hydroxyapatite, polycaprolactone (PCL), and poly‐L‐lactic acid (PLLA), and other materials have been tested. Polydioxanone (PDO) has recently been used as absorbable thread‐lifting material due to its collagen‐forming effects. PDO in powdered form is expected to be a good material for collagen‐producing fillers. Objectives To evaluate the collagen‐producing effects of powdered PDO injection compared with PLLA injection in a murine model. Materials and Methods Powdered PDO mixed with sodium carboxymethyl cellulose, PLLA, and phosphate‐buffered saline was injected on dorsal skin of 8‐week‐old rat. Tissue samples were obtained 1, 2, and 12 weeks after the procedures for histopathologic review and for real‐time PCR to quantify collagen and tissue growth factors. Results Both PLLA and powdered PDO injections induced granulomatous reactions. Collagen type 1, collagen type 3, TGF‐β1, TGF‐β2, and TGF‐β3 showed increases 2 weeks after injection but decreased 12 weeks after injection for both powdered PDO and PLLA. Conclusion Our results suggested that powdered PDO injection induces collagen formation more effectively than PLLA injection. Therefore, PDO can be a good option for forming collagen.

Clinical features and literature review related to the material differences in thread rhinoplasty: Two case reports

“…The injection of PDO thread acts as a powerful stimulant of collagen formation. The immediate effect of thread insertion is tissue lift due to the mechanical effect[ 3 , 7 ]. Yoon et al [ 7 ] reported that the PDO thread induces fibrous connective tissue formation, an increase in the number of nearby capillary vessels, and a reduction in the thickness of the fat layer due to fat cell denaturation.…”

“…The immediate effect of thread insertion is tissue lift due to the mechanical effect[ 3 , 7 ]. Yoon et al [ 7 ] reported that the PDO thread induces fibrous connective tissue formation, an increase in the number of nearby capillary vessels, and a reduction in the thickness of the fat layer due to fat cell denaturation. The PDO begins to disassemble after 3 mo of thread insertion and disappears by 6 mo[ 8 ].…”

“…The PDO begins to disassemble after 3 mo of thread insertion and disappears by 6 mo[ 8 ]. Even after the loss of PDO, the collagen-inducing effect of PDO threads persisted for more than 10 mo[ 7 ].…”

Skin Aging & Modern Age Anti-Aging Strategies

“…This in lammatory reaction elicits resorption and the formation of ibrous connective tissue about the foreign body, causing dermal ibroplasia that leads to the desired cosmetic effect [2]. Kim et al, 2019 reported that powdered polydioxanone injection induces collagen formation more effectively than PLLA injection [215].…”

“…Botelho et al, 2014 nanostructured formulation of progesterone (10%) combined with estriol (0.1%) + estradiol (0.25%) is safe and effective in re-establishing optimal serum levels of estradiol and follicle-stimulating hormone and relieving the symptoms of menopause [223]. Abdi et al, 2017 also concluded that use of transdermal nanoformulations in hormone therapy can relieve climacteric symptoms and prevent other postmenopausal symptoms [226][227][228][229][230][231][232][233][234][235][236][237][238][239][240][241][242][243][244][245].…”