Dentinogenesis Imperfecta and Caries in Osteogenesis Imperfecta among Vietnamese Children

Abstract

Osteogenesis imperfecta (OI) is a genetic disorder characterized by increased bone fragility and low bone mass, caused mainly by mutations in collagen type I encoding genes. The current study aimed to evaluate dentinogenesis imperfecta (DI), oral manifestations and caries status of OI children. Sixty-eight children (41 males, 27 females) aged from 3 to 17 years old (mean 9 ± 4.13) participated in the study. Participants were classified into three OI type groups (I—2 cases, III—31 cases and IV—35 cases). Clinical examination and an orthopantomogram were used to obtain prevalences and associations of DI, caries status, malocclusion, crossbite, open bite, eruption, impaction and missing teeth with OI. The prevalence of DI among OI patients was 47.1%, more common in OI type III than type IV. The yellow-brown discoloration type was more vulnerable to attrition than the opalescent-grey one in the primary dentition. OI seemed not to have a high risk of caries; the prevalence of caries was 69.1%. A high incidence of malocclusion, crossbite and open bite was observed. In-depth oral information would provide valuable data for better dental management in OI patients. Parents and general doctors should pay more attention to dental care to prevent caries and premature tooth loss.

Biomechanical, Microstructural and Material Properties of Tendon and Bone in the Young Oim Mice Model of Osteogenesis Imperfecta

“…Aside from skeletal alterations and symptoms, teeth, which are also mineralized tissues rich in collagen type I, are commonly implicated in OI [ 4 ]. They exhibit discoloration and translucency and can be worn off prematurely.…”

Oral manifestations and rehabilitation of a patient with osteogenesis imperfecta

“…Moreover, it is followed by insufficient amount of bone, the cortical thickness and decreased amount of trabecular bone [28]. Malmgren et al reported that individuals with OI had a high prevalence of missing teeth, with a predilection for the posterior regions of the jaws [11]. Panoramic radiograph of our patient revealed underdeveloped upper and lower jaw.…”

“…In addition to numerous fractures, patients might display short stature, hearing impairment, blue sclerae, skeletal deformities that affect craniofacial structures such as triangular facial form, large head size and soft calvaria [8]. The incidence of orofacial alterations associated with osteogenesis imperfecta is variable and includes dentinogenesis imperfecta (DI), maxillary hypoplasia, skeletal class III deformity, crossbite, open bite, hypodontia/oligodontia and delayed dental development [9][10][11].…”

Uma abordagem geral da Osteogênese imperfeita

“…Os sinais clínicos aparecem como descoloração opalescente cinza-azulada ou marrom-amarelada dos dentes. Devido à deserção da dentina subjacente (colágeno tipo I), os dentes se apresentam radiograficamente com baixa densidade de mineralização, coroas bulbosas, constrição cervical, raízes curtas e obliteração do canal pulpar (TAQI D, et al, 2021;NGUYEN HTT, et al, 2021).…”