Dental Health Status in Children with Acute Lymphoblastic Leukemia

Nasim, V S; Shetty, Y Rajmohan; Hegde, Amitha M

doi:10.17796/jcpd.31.3.73mu542187l75700

Cited by 21 publications

(19 citation statements)

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“…Conflicting results have been reported by Hegde et al [37] and Nasim et al [41] Although the negative effects of anticancer therapy on SFR are well-established; [37,[41][42][43] studies have reported that the oral mucosal inflammation induced by chemotherapy, may prevent some patients from performing daily oral hygiene maintenance regimes. [42,44] Hence, hematology patients need special dental considerations beside antineoplastic treatments.…”

Section: Discussionmentioning

confidence: 97%

Untitled

Bassir

2017

AJP

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Purpose: This study was aimed to evaluate the caries activity in children with acute lymphoblastic leukemia (ALL) undergoing maintenance stage chemotherapy courses. Materials and Methods: This is an observationalanalytical and case-control study conducted on the 27 children (4-12 years old) with ALL who were in the maintenance phase of chemotherapy in the Ahvaz Shafa Hospital, Iran. The participants of the control group, matched in terms of age, gender, and cultural status with the case group, were selected among the healthy children referred to Ahvaz Razi Hospital, Iran. The children received only a clinical dental examination without radiographs. The number of decayed (D), missing (M) and filled (F), and teeth (T) were recorded based on the WHO based DMFT index and without the use of radiography. Then, after radiographic assessment, the stimulated saliva samples were collected from the subjects to assess the salivary Streptococcus mutans counts, salivary Lactobacilli counts, and salivary buffer capacity. Results: The salivary S. mutans counts in ALL children were significantly higher than the control group (P < 0.001). In both groups, Lactobacilli counts and salivary pH and DMFT were similar (P > 0.05). Furthermore, the ALL group tended to have lower salivary flow rate than healthy subjects (P < 0.05). Conclusions: Specific oral prevention regimes should be planned with more cautions for children suffered hematology illness undergoing antineoplastic therapy with respect to children without blood problems.

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Section: Discussionmentioning

confidence: 97%

Untitled

Bassir

2017

AJP

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“…The gingival tissue in ALL children is usually deep red, swollen, and prone to bleeding [1]. The gingival swelling is due to leukemic infiltration in gingival tissue, and the gingival tissue destruction is caused by chemotherapeutic agents [3].…”

Section: Discussionmentioning

confidence: 99%

“…Acute lymphoblastic leukemia (ALL) is the most common type of leukemia [2]. ALL accounts for 75% of all acute leukemia [3]. In children, it occurs in ages 2-5, and it occurs more frequently in boys than girls [4].…”

Section: Introductionmentioning

confidence: 99%

Effects of a Probiotic Milk Drink on Salivary Tumor Necrosis Factor-Alpha in Children With Acute Lymphoblastic Leukemia in the Induction Phase

Pariaputra

Budiardjo

Suharsini

2018

Asian J Pharm Clin Res

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Objective: The aim of this study was to investigate the effects of the short-term use of a probiotic milk drink on salivary tumor necrosis factor-alpha (TNF-α) in children with acute lymphoblastic leukemia (ALL) during the induction phase of chemotherapy. Methods:A randomized, case-controlled clinical trial was carried out. The samples of the study were collected from 11 children with ALL and 11 healthy children as the control. Both groups received a probiotic milk drink. The probiotic milk drink contained Lactobacillus casei (6.5×10 9 colony forming unit/mL). The subjects were instructed to rinse 5 mL of probiotic milk drink for 30 s over the course of 2 weeks. Unstimulated saliva samples were collected from patients at baseline and 1 and 2 weeks after rinsing with the probiotic milk drink. The levels of TNF-α were determined using a human TNF-α enzyme-linked immunosorbent assay kit. Results:The salivary TNF-α levels in the experimental group decreased but not to a statistically significant degree (p>0.05) when comparing the baseline with weeks 1 and 2 after rinsing. There was a significant decrease of salivary TNF-α levels in the control group (p<0.05) when comparing the baseline with 1 and 2 weeks after rinsing. The concentration of salivary TNF-α in the experimental group was higher than in the control group (p<0.05). Conclusion:This study demonstrates the effect of a short-term intake of a probiotic milk drink on children with ALL during the induction phase of chemotherapy. The results show a reduction of salivary TNF-α after taking the probiotic milk drink after 1 week and 2 weeks, although the results were not statistically significant.

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“…Dentre essas manifestações, destacam-se: sangramento gengival, formação de petéquias na mucosa alveolar, crescimento gengival, ulcerações e infecções (28) . O sangramento gengival encontra-se relacionado à trombocitopenia, sendo mais frequente no sulco gengival, mesmo na ausência de gengivite detectável clinicamente (29,30) . A tendência ao sangramento também pode ser observada na mucosa bucal, manifestada em forma de petéquias (28) .…”

Section: Leucemiasunclassified

“…Estudos sugerem que indivíduos com início precoce de doença periodontal podem ter doença sistêmica ou apresentar alterações no sistema imunológico (5)(6)(7)(8)(9)(10) . A hipofosfatasia (11)(12)(13) , a histiocitose X (6,(13)(14)(15) , a síndrome de Down (7,(16)(17)(18)(19)(20) , a síndrome de Papillon-Lefèvre (6,11,13,(21)(22)(23) , a síndrome de Ehlers-Danlos (3,6,11,13) , a síndrome de Chédiak-Higashi (6,13,(24)(25) , doenças que levam à neutropenia (21,(25)(26)(27) e disfunções de neutrófilos (6,13,21,25) como deficiência de moléculas de adesão e alterações de quimiotaxia, leucemia (28)(29)(30)(31) e Aids (28,(32)(33)…”

Section: Introductionunclassified

Alterações periodontais associadas às doenças sistêmicas em crianças e adolescentes

Vieira

Péret

Filho³

2010

Rev. paul. pediatr.

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OBJETIVO: O objetivo deste estuo foi revisar na literatura a inter-relação entre condições sistêmicas e a ocorrência de doenças periodontais em crianças e adolescentes, destacando-se as manifestações periodontais frequentemente encontradas. FONTES DE DADOS: Artigos indexados nas bases de dados Medline, Lilacs e Bibliografia Brasileira em Odontologia, nos últimos 20 anos, além de referências clássicas. As palavraschave utilizadas foram: "doença periodontal", "periodontite", "doenças sistêmicas", "criança" e "adolescente". SÍNTESE DOS DADOS: Doenças sistêmicas como hipofosfatasia, histiocitose X, síndrome de Down, síndrome de Papillon-Lefèvre, síndrome de Ehlers-Danlos, síndrome de Chédiak-Higashi, leucemias, Aids e as deficiências quantitativas e qualitativas dos neutrófilos estão associadas ao aparecimento de alterações periodontais graves em crianças e adolescentes. Os estudos demonstraram a ocorrência de alteração periodontal na forma de periodontite em crianças e adolescentes com doenças sistêmicas, podendo levar à perda precoce de dentes. CONCLUSÕES: A ocorrência de alterações periodontais é observada em crianças e adolescentes com alterações sistêmicas, que manifestam desde inflamação gengival até formas mais destrutivas, como periodontites e perda precoce dos dentes.

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Dental Health Status in Children with Acute Lymphoblastic Leukemia

Cited by 21 publications

References 1 publication

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Effects of a Probiotic Milk Drink on Salivary Tumor Necrosis Factor-Alpha in Children With Acute Lymphoblastic Leukemia in the Induction Phase

Alterações periodontais associadas às doenças sistêmicas em crianças e adolescentes

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