Dental Development of Chinese Children with Cleft Lip and Palate

Lai, Moon Cheung; King, Nigel M.; Wong, Hai Ming

doi:10.1597/07-019

Cited by 34 publications

(40 citation statements)

References 38 publications

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“…Similarly, Eerens et al 16 (2001) reported a slight delay in the dental development of Belgian children. Despite the concordance, both studies contradict most of the previous investigations 7,[9][10][11][12][13]15,[17][18][19][20] , which reported statistically significant delays in the dental development of individuals with cleft lip and palate. Moreover, some studies lack information concerning the performed methodology 7,15 , hampering adequate interpretations.…”

Section: Discussioncontrasting

confidence: 77%

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Dental development of children and adolescents with cleft lip and palate

Topolski¹,

Souza²,

Franco³

et al. 2014

Braz. J. Oral Sci.

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Aim: To evaluate the dental development of Brazilian children and adolescents with cleft lip and palate. Methods: The sample consisted of 107 panoramic radiographs of children and adolescents with cleft lip and/or palate (cleft group) and 107 panoramic radiographs of children and adolescents without cleft lip and/or palate (control group), with chronological ages ranging from 6 to 15 years, matched in gender and chronological age within 60 days. Radiographs were digitized and masked and dental age was assessed using the method described by Demirjian et al. (1973). Three trained examiners conducted the assessments. Each examiner evaluated the radiographs three times. Data were statistically analyzed using non-parametric tests and univariate linear regression (p<0.05). Results: The dental age was overestimated in relation to the chronological age in both groups (p<0.0001). Compared to the control group, there was a delay in the dental age in the cleft group of 0.17 years (2.1 months). However, no statistically significant difference in the dental age between the cleft and the control group was found even when considering the different cleft types (p=0.152). Conclusions: There was no statistically significant difference in the dental age between the cleft and the control groups. The evaluation of dental development in individuals with cleft lip and palate should be approached in the same way as in individuals without clefts, with a focus on the individualization of diagnosis and treatment planning.

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Section: Discussioncontrasting

confidence: 77%

“…In addition, contrarily to previous studies [7][8][9][11][12][13]15,[17][18][19][20] a blinding methodology was applied to avoid potential bias during the image analysis. The blinding methodology plays an important part in the study reliability, since the method of Demirjian et al 14 (1973) presents a certain degree of subjectivity.…”

Section: Discussionmentioning

confidence: 99%

Dental development of children and adolescents with cleft lip and palate

Topolski¹,

Souza²,

Franco³

et al. 2014

Braz. J. Oral Sci.

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“…Chinese individuals with CLP from Shanghai in China have been shown to display a higher frequency of fingerprint whorls when compared to Filipino individuals from the Negro Occidental and Cavite provinces in the Philippines [10,44]. Likewise, the difference in the number of asymmetrical tooth pairs between Chinese children with and without CLP in Hong Kong is higher than that reported for other ethnic groups [45]. Also, fluctuating asymmetry has also been associated with indicators of developmental stability (e.g., psychometric intelligence), specific disorders (e.g., Fragile X syndrome) and nonspecific forms of mental retardation [43].…”

Section: Language Skills In Children With Clpmentioning

confidence: 73%

Expressive language skills in Chinese Singaporean preschoolers with nonsyndromic cleft lip and/or palate

Young

Purcell

Ballard

2010

International Journal of Pediatric Otorhinolaryngology

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“…Tooth agenesis was identified from serial panoramic radiographs based on the age of the subject and considering the fact that the mean delay in tooth formation of the cleft children was approximately 4 to 6 months relative to that of non-cleft children. 1,24 Regardless of size and morphology, any permanent tooth on either side of the alveolar cleft between the maxillary central incisor and canine was considered existence of the maxillary lateral incisor (MXLI). 25,26 TAT was divided into none; cleft area only (missing of the MXLI within the cleft area only), cleft area + other area (missing of the MXLI within the cleft area and another maxillary tooth outside the cleft area), and other area only (missing of another maxillary tooth outside the cleft area only) ( Figure 1).…”

Section: Methodsmentioning

confidence: 99%

Associations between the risk of tooth agenesis and single-nucleotide polymorphisms of MSX1 and PAX9 genes in nonsyndromic cleft patients

Seo

Park

Kim

et al. 2013

The Angle Orthodontist

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Objective: To investigate the association between the risk of tooth agenesis and single-nucleotide polymorphisms (SNPs) of MSX1 and PAX9 genes in nonsyndromic cleft patients. Materials and Methods: The subjects were 126 Korean nonsyndromic cleft patients. Tooth agenesis type (TAT) was classified as none (0); cleft area (1); cleft area + other area (2); and other area (3) based on agenesis of the maxillary lateral incisor (MXLI) and another tooth within or outside the cleft area. TAT was further grouped into two subcategories (0 and 1) and four subcategories (0, 1, 2, and 3). Three SNPs of MSX1 and 10 SNPs of PAX9 were investigated using Fisher's exact test and logistic regression analysis. Results: Although the association between genotype distribution of PAX9-rs7142363 and TAT was significant (P , .05 in four subcategories), genotypic odds ratios (GORs) of SNPs in each TAT were not meaningful. However, for MSX1-rs12532 and PAX9-rs2073247, associations between genotypic distribution and TAT were significant (P , .01 in four subcategories and P , .05 in two subcategories; P , .01 in two subcategories, respectively). In cleft area, GORs of MXLI agenesis in genotypes GA of MSX1-rs12532 and CT of PAX9-rs2073247 were increased by 3.14-fold and 4.15-fold compared with genotype GG of MSX1-rs12532 and CC of PAX9-rs2073247, respectively (P ,. 01; P , .05). In cleft area + other area, the GOR of agenesis of MXLI and another tooth in genotype AA of MSX1-rs12532 was increased by fivefold compared with genotype GG (P , .05). Conclusion: Genetic disturbances of MSX1 and PAX9 genes are associated with tooth agenesis within and outside the cleft area. (Angle Orthod. 2013;83:1036-1042

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Dental Development of Chinese Children with Cleft Lip and Palate

Abstract: This group of southern Chinese children with cleft lip and palate demonstrated a higher prevalence of asymmetric and delayed dental development than did their counterparts who did not have cleft lip and palate.

Cited by 34 publications

References 38 publications

Dental development of children and adolescents with cleft lip and palate

Dental development of children and adolescents with cleft lip and palate

Expressive language skills in Chinese Singaporean preschoolers with nonsyndromic cleft lip and/or palate

Associations between the risk of tooth agenesis and single-nucleotide polymorphisms of MSX1 and PAX9 genes in nonsyndromic cleft patients

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