Dental-derived stem cells and biowaste biomaterials: What’s next in bone regenerative medicine applications

Cosola, Michele Di; Cantore, Stefania; Giosubalzanelli, Mario; Isacco, Ciro Gargiulo; Nguyen, Kieu Cao Diem; Saini, Rajiv; Malcangi, A; Tumedei, Margherita; Ambrosino, Mariateresa; Mancini, Antonio; Scacco, Salvatore; Nocini, Riccardo; Santacroce, Luigì; Ballini, Andrea; Brauner, Edoardo

doi:10.32604/biocell.2022.018409

Cited by 4 publications

(1 citation statement)

References 55 publications

(57 reference statements)

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“…[47] Oertel et al suggested that articaine should be selected for local anesthesia in outpatient surgery of oral and maxillofacial surgery. [40] [48,49] In the past, using lidocaine for nerve block anesthesia was the main anesthesia method in oral implantology; however, the onset time of anesthesia was long, the failure rate of anesthesia was high, and it was difficult to control the extent of anesthesia. If the inferior alveolar nerve is damaged during the operation, the patient has no pain response and cannot provide timely feedback to the operator, which increases the risk of surgery.…”

Section: Application Of Articaine In Oral and Maxillofacial Surgerymentioning

confidence: 99%

The potential of articaine as new generation of local anesthesia in dental clinics: A review

et al. 2022

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As a new drug for local dental anesthesia, articaine has become popular in the clinic in recent years. In this review, we describe the development of articaine, explain its mechanism of action, compare its efficacy with that of other commonly used local anesthetics in dental treatment, and summarize the application of articaine in special populations. In conclusion, the anesthetic efficacy of articaine in clinical dental treatment is better than that of lidocaine, and its safety is not statistically different from that of lidocaine. In particular, articaine has several advantages and can be selected flexibly for clinical use. Atecaine has great potential for wide application in dental clinics in the near future.

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Section: Application Of Articaine In Oral and Maxillofacial Surgerymentioning

confidence: 99%

The potential of articaine as new generation of local anesthesia in dental clinics: A review

et al. 2022

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Optimization of Cobalt-Chromium (Co-Cr) Scaffolds for Bone Tissue Engineering in Endocrine, Metabolic and Immune Disorders

Rodríguez-Montaño,

Vaiani,

Boccaccio

et al. 2024

EMIDDT

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Approximately 50% of the adult global population is projected to suffer from some form of metabolic disease by 2050, including metabolic syndrome and diabetes mellitus. At the same time, this trend indicates a potential increase in the number of patients who will be in need of implant-supported reconstructions of specific bone regions subjected to inflammatory states. Moreover, physiological conditions associated with dysmetabolic subjects have been suggested to contribute to the severity of bone loss after bone implant insertion. However, there is a perspective evidence strengthening the hypothesis that custom-fabricated bioengineered scaffolds may produce favorable bone healing effects in case of altered endocrine or metabolic conditions. This perspective review aims to share a comprehensive knowledge of the mechanisms implicated in bone resorption and remodelling processes, which have driven researchers to develop metallic implants as the cobalt-chromium (Co-Cr) bioscaffolds, presenting optimized geometries that interact in an effective way with the osteogenetic precursor cells, especially in the cases of perturbed endocrine or metabolic conditions.

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Heavy Metal Pollution and Male Fertility: An Overview on Adverse Biological Effects and Socio-Economic Implications

Crocetto

Risolo

Colapietro

et al. 2023

EMIDDT

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Trace metals can be divided into two subgroups considering their pathophysiological effects: the first consists of microelements essential for life (arsenic, cobalt, chromium, copper, fluorine, iron, iodine, manganese, molybdenum, nickel, selenium, silicon, tin, vanadium and zinc), implicated in important metabolic processes; the second includes toxic microelements, such as cadmium (Cd), mercury (Hg), chromium (Cr), and lead (Pb) for living organisms, even at low concentrations. These metals contribute to serious consequences for human health, including male infertility. Studies performed in several in vitro and in vivo models revealed that environmental exposure to toxic pollutants, as heavy metals, negatively affects human male fertility. Stem cells, due to their ability to self-renew and differentiate in several cell types, have been proposed as an useful tool in assisted reproductive technology, permitting the spermatogenesis recovery in patients with irreversible infertility. Considering the effects of heavy metals on male fertility and, from a demographic point of view, the decreased fertility ratio, further strategies are required to maintain a sustainable turn-over of 2 children for woman. We discuss here the findings on the biological effects of heavy metal pollution in the male fertility and underline the related socio-economic impact on population demography.

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Dental-derived stem cells and biowaste biomaterials: What’s next in bone regenerative medicine applications

Cited by 4 publications

References 55 publications

The potential of articaine as new generation of local anesthesia in dental clinics: A review

The potential of articaine as new generation of local anesthesia in dental clinics: A review

Optimization of Cobalt-Chromium (Co-Cr) Scaffolds for Bone Tissue Engineering in Endocrine, Metabolic and Immune Disorders

Heavy Metal Pollution and Male Fertility: An Overview on Adverse Biological Effects and Socio-Economic Implications

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