Dense fine-grained biphasic calcium phosphate (BCP) bioceramics designed by two-step sintering

Lukić, Miodrag J.; Stojanović, Zoran; Škapin, Srečo D.; Kržmanc, Marjeta Maček; Mitrić, Miodrag; Marković, Smilja; Uskoković, Dragan

doi:10.1016/j.jeurceramsoc.2010.09.006

Cited by 67 publications

(43 citation statements)

References 46 publications

(40 reference statements)

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“…From the chemical composition point of view, the vast majority of calcium orthophosphate bioceramics is based on HA, β-TCP, α-TCP and/or biphasic calcium phosphate (BCP). BCP is an intimate mixture of either β-TCP + HA [111][112][113][114][115][116][117][118][119][120][121][122][123][124][125][126] or α-TCP + HA [8][9][10][11][12]) [127][128][129][130][131][132][133][134][135][136]. One should note that recently the concept of BCP has been extended by preparation and characterization of biphasic TCP (BTCP), consisting of both α-TCP and β-TCP phases [137][138][139][140][141].…”

Section: Chemical Composition and Preparationmentioning

confidence: 99%

“…Furthermore, submicron-sized HA powders are biodegraded even faster than the highly porous HA scaffolds. Other examples of bioresorbable materials include porous bioceramic scaffolds made of BCP (which is an intimate mixture of either β-TCP + HA [111][112][113][114][115][116][117][118][119][120][121][122][123][124][125][126] or α-TCP + HA [8][9][10][11][12]) or bone grafts (dense or porous) made of CDHA [152], TCP [411,596,597] and/or ACP [462,598]. One must stress that recently the concepts of bioactive and bioresorbable materials have converged and bioactive materials are made bioresorbable, while bioresorbable materials are made bioactive [599].…”

Section: Interaction With Surrounding Tissues and The Host Responsesmentioning

confidence: 99%

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Medical Application of Calcium Orthophosphate Bioceramics

Dorozhkin¹

2011

BIO

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In the late 1960's, a strong interest was raised in biomedical applications of ceramic materials (named bioceramics a little bit later). Bioceramics was initially used as reasonable alternatives to metals in order to increase their biocompatibility. However, within a short period, it has grown into a diverse class of biomaterials, presently including three essential types: relatively bioinert, bioactive (or surface reactive) and bioresorbable bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30 -40 years. The research was shifted from an initial study on the develop-ment of bioinert bioceramics towards bioactive and bioresorbable bioceramics, and these different types of calcium orthophosphate bioceramics can be tuned through the structural and compositional control. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics has been developed to promote a regeneration of bones. Current biomedical applications of calcium orthophosphate bioceramics include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmenttation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Potential future applications of calcium orthophosphate bioceramics are demonstrated in drug delivery systems, effective carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

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Section: Chemical Composition and Preparationmentioning

confidence: 99%

Section: Interaction With Surrounding Tissues and The Host Responsesmentioning

confidence: 99%

Medical Application of Calcium Orthophosphate Bioceramics

Dorozhkin¹

2011

BIO

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“…A detailed characterization of SHAp and CDHAp powders was the subject of our previous papers [34][35][36]. Here, we point out the powders' properties: phase composition, degree of crystallinity, particle size distribution, stoichiometry, morphology and specific surface area, which influenced sinterability and consequently the quality of the FGMs.…”

Section: Characteristics Of Starting Powdersmentioning

confidence: 94%

“…The precipitate was washed out to pH 7 with distilled water to remove residual ions. After filtering, the filter cake was dried in an oven at 80 1C during 18 h, and grounded to obtain the powdered materials [34][35][36]. Phase composition of the powders was determined using a powder X-ray diffractometer (Philips PW 1050; Almelo, The Netherlands).…”

Section: Starting Powdersmentioning

confidence: 99%

“…Continuing our previous studies on fabrication of dense nanostructured hydroxyapatite [34], and calcium deficient hydroxyapatite [35] ceramics, here, we deal with their combination with the aim to prepare FGM with unique properties. The idea of this study was to establish a model system for engineering of nanostructured calcium phosphate sintered ceramics with simultaneous spatial gradients of microstructure (density), phase composition (HAp/β-TCP ratio), and mechanical properties (hardness and Young's modulus).…”

Section: Introductionmentioning

confidence: 99%

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Designing, fabrication and characterization of nanostructured functionally graded HAp/BCP ceramics

Marković

Lukić

Škapin

et al. 2015

Ceramics International

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Nanostructured calcium phosphate functionally graded materials (FGMs) with simultaneous gradients of density, phase composition, and mechanical properties were fabricated by consecutive uniaxial pressing of stoichiometric (SHAp) and calcium deficient (CDHAp) hydroxyapatite powders in multilayered samples and reaction sintering. During sintering procedure SHAp composition remained stable (HAp) while CDHAp was phase transformed in biphasic calcium phosphate (BCP, i.e. HAp þβ-TCP) yielding HAp/BCP FGMs. To reduce mismatch stress between adjacent layers, generated during sintering, gradient of phase composition was optimized by introducing intermediate layer(s) made from a mixture of SHAp and CDHAp in an appropriate mass ratio. Optimal processing conditions for preparation of nanostructured ceramics were provided via two-step sintering. High-quality FGMs structure, without delamination, cracks and micro-structural damages was observed by an SEM technique; moreover, a detailed examination by FE-SEM established the unidirectional (perpendicular with respect to the layers) gradual change of microstructure, from fully dense to $40% of porosity. Detailed micro-Raman and FTIR spectroscopy studies showed an increase of β-TCP amount along the FGMs height, confirming gradient of phase composition. Mechanical properties measured by microindentation revealed gradual change of microhardness from 650 to 115 HV, with simultaneous change of Young's modulus from 92 to 24 GPa.

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Biphasic, Triphasic, and Multiphasic Calcium Orthophosphates

Dorozhkin¹

2016

Advanced Ceramic Materials

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Dense fine-grained biphasic calcium phosphate (BCP) bioceramics designed by two-step sintering

Cited by 67 publications

References 46 publications

Medical Application of Calcium Orthophosphate Bioceramics

Medical Application of Calcium Orthophosphate Bioceramics

Designing, fabrication and characterization of nanostructured functionally graded HAp/BCP ceramics

Biphasic, Triphasic, and Multiphasic Calcium Orthophosphates

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