Biphasic, Triphasic, and Multiphasic Calcium Orthophosphates

Dorozhkin, Sergey V.

doi:10.1002/9781119242598.ch2

Cited by 27 publications

(35 citation statements)

References 408 publications

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“…A faster resorbing component, such as calcium sulphate, can dissolve quickly, allowing high early release of antibiotic and leaving behind a porous scaffold offering more prolonged structural stability and bone ingrowth 56. There is a fine balance in optimising new bone formation: if resorption is too slow, the ceramic will obstruct bone healing; if resorption is too fast, gaps will form between the ceramic and the bone which are too wide to bridge 49.…”

Section: Polyphasic Bioceramicsmentioning

confidence: 99%

Ceramic Biocomposites as Biodegradable Antibiotic Carriers in the Treatment of Bone Infections

Ferguson

Diefenbeck

McNally

2017

J. Bone Joint Infect.

130

153

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Local release of antibiotic has advantages in the treatment of chronic osteomyelitis and infected fractures. The adequacy of surgical debridement is still key to successful clearance of infection but local antibiotic carriers seem to afford greater success rates by targeting the residual organisms present after debridement and delivering much higher local antibiotic concentrations compared with systemic antibiotics alone. Biodegradable ceramic carriers can be used to fill osseous defects, which reduces the dead space and provides the potential for subsequent repair of the osseous defect as they dissolve away. A dissolving ceramic antibiotic carrier also raises the possibility of single stage surgery with definitive closure and avoids the need for subsequent surgery for spacer removal.In this article we provide an overview of the properties of various biodegradable ceramics, including calcium sulphate, the calcium orthophosphate ceramics, calcium phosphate cement and polyphasic carriers. We summarise the antibiotic elution properties as investigated in previous animal studies as well as the clinical outcomes from clinical research investigating their use in the surgical management of chronic osteomyelitis.Calcium sulphate pellets have been shown to be effective in treating local infection, although newer polyphasic carriers may support greater osseous repair and reduce the risk of further fracture or the need for secondary reconstructive surgery. The use of ceramic biocomposites to deliver antibiotics together with BMPs, bisphosphonates, growth factors or living cells is under investigation and merits further study.We propose a treatment protocol, based on the Cierny-Mader classification, to help guide the appropriate selection of a suitable ceramic antibiotic carrier in the surgical treatment of chronic osteomyelitis.

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Section: Polyphasic Bioceramicsmentioning

confidence: 99%

Ceramic Biocomposites as Biodegradable Antibiotic Carriers in the Treatment of Bone Infections

Ferguson

Diefenbeck

McNally

2017

J. Bone Joint Infect.

130

153

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“…The current market offers a wide range of calcium phosphate-based biomaterials as substitutes for bone tissue. Most representative materials are hydroxyapatite (HA), beta-tricalcium phosphate (β-TCP) and different combinations of these, generally named biphasic calcium phosphates (BCP) [2,3,[6][7][8]. The main reason for using calcium phosphate-based biomaterials is their resemblance with the bone tissue, so research and development of this area tends to reproduce more accurately the damaged tissue, with more efficient results.…”

Section: Introductionmentioning

confidence: 99%

Biomimetic Calcium Phosphates Derived from Marine and Land Bioresources

Miculescu¹,

Mocanu²,

Maidaniuc³

et al. 2018

Hydroxyapatite - Advances in Composite Nanomaterials, Biomedical Applications and Its Technological Facets

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This chapter aims to establish the key factors for technological optimization of biogenic calcium phosphate synthesis from marine and land resources. Three natural calcium sources-marble, seashell and bovine bone-were considered as raw materials. The proposed materials are suitable candidates for the synthesis of bone substitutes similar to the inorganic bone component. The synthesis processes were developed based on the investigations of thermal phenomena (TGA-DSC analysis) that can occur during thermal treatments. By this method, we were able to determine the optimum routes and temperatures for the complete dissociation of calcium carbonate as well as risk-free deproteinization of bovine bone. An exhaustive characterization, performed with modern and complementary techniques such as morphology (SEM), composition (EDS, XRF) and structure (FT-IR, XRD), is presented for each precursor. The final chemical composition of ceramic products can be modulated through a careful control of the key parameters involved in the conversion, in order to create long-term performant biphasic apatite biomaterials, with broad medical applicability. Identifying the suitable strategies for this modulation contributes to an appreciable advance in orthopedic tissue engineering.

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“…48 Furthermore, the thermal treatment can also induce non-structural and structural changes in the phase composition of biomaterials that can be traced as alterations in FTIR absorption bands. 11,50 However, high calcination temperatures-once the temperature exceeds 900 C, notably if >1200 C-would increase the chance of phase transformation and chemical decomposition of bioceramics phases 28 which result in the appearance of secondary phases. 48 The impact of calcining temperature on structural groups has also been observed where a lower temperature (≤500 C) has resulted in a broader phosphate band (at 1000 cm −1 ) and absence of hydroxyl band (at 3670 and 631 cm −1 ) in nHA.…”

Section: Modification Of Calcination Parameters and Their Importancementioning

confidence: 99%

Synthesis and characterization of biomimetic bioceramic nanoparticles with optimized physicochemical properties for bone tissue engineering

Ebrahimi

Botelho

et al. 2019

J Biomedical Materials Res

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Calcium phosphate bioceramics nanoparticles such as nano‐hydroxyapatite (nHA) and nano‐tricalcium phosphate (nTCP) are the main focus of basic and applied research for bone tissue regeneration. In particular, a combination of these two phases (nHA + nTCP) which refers to as “nano‐biphasic calcium phosphates (nBCP)” is of interest due to the preferred biodegradation nature compared to single‐phase bioceramics. However, the available synthesis processes are challenging and the biomaterials properties are yet to be optimized to mimic the physiochemical properties of the natural nanoscale bone apatite. In this study, a new approach was developed for the production of optimized bioceramic nanoparticles aiming to improve their biomimecity for better biological performances. Nanoparticles were synthesized through a carefully controlled and modified wet mechano‐chemical method combined with a controlled solid‐state synthesis. Different processing variables have been analyzed including; milling parameters, post‐synthesis treatment, and calcination phase. Detailed physicochemical characterizations of nanoparticles revealed higher crystallinity (∼100%), lower crystallite/particle size (58 nm), higher homogeneity, reduced particle agglomeration size (6 μm), and a closer molar ratio (1.8) to biological apatite compared to control and standard samples. Furthermore, the study group was confirmed as calcium‐deficient carbonate‐substituted BCP nanoparticles (nHA/nβ‐TCP: 92/8%). As such, the introduced method can afford an easier and accurate control over nanoparticle physiochemical properties including the composition phase which can be used for better customization of biomaterials for clinical applications. The findings of this article will also help researchers in the further advancement of production strategies of biomaterials. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 107A: 1654–1666, 2019.

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Biphasic, Triphasic, and Multiphasic Calcium Orthophosphates

Cited by 27 publications

References 408 publications

Ceramic Biocomposites as Biodegradable Antibiotic Carriers in the Treatment of Bone Infections

Ceramic Biocomposites as Biodegradable Antibiotic Carriers in the Treatment of Bone Infections

Biomimetic Calcium Phosphates Derived from Marine and Land Bioresources

Synthesis and characterization of biomimetic bioceramic nanoparticles with optimized physicochemical properties for bone tissue engineering

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