Dengue fever and COVID‐19 coinfection; a threat to public health for coepidemic in Pakistan

Butt, Muhammad Hammad; Ahmad, Abrar; Misbah, Shahzadi; Mallhi, Tauqeer Hussain; Khan, Yusra Habib

doi:10.1002/jmv.26464

Cited by 19 publications

(25 citation statements)

References 8 publications

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“…In this sense, it has been hypothesized that such countries possibly experienced an aggravated COVID-19 pandemic due to socioeconomic ( de Sousa et al, 2020 ; Martins-FiIho et al, 2020 ) and health factors, such as other ongoing epidemics like dengue fever. Indeed, COVID-19/dengue co-infection has been reported in endemic and even in non-endemic countries, the consequences of such co-infection being mostly unknown at this point ( Butt et al, 2020 ; Estofolete et al, 2020 ; Lazzarini et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Clinical and biochemical parameters of COVID-19 patients with prior or active dengue fever

et al. 2021

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Highlights The SARS-CoV-2 and dengue syndemic is a reality in several countries worldwide. Prior dengue infection did not impact clinical parameters of COVID-19 patients. Active dengue fever worsened the pulmonary function of COVID-19 patients. Active and prior dengue infection were associated with an increase in blood glucose levels.

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Section: Introductionmentioning

confidence: 99%

Clinical and biochemical parameters of COVID-19 patients with prior or active dengue fever

et al. 2021

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“…The co-infection cases described to date, together with the 13 cases reported herein, highlight the difficulty in reaching the final diagnosis, since both diseases share similar signs, symptoms and laboratory features. These obstacles in the diagnostic process can be detrimental to the patient’s condition and increase the burden on the healthcare system, especially in the context of the COVID-19 pandemic, as these are diseases with substantial morbidity and mortality [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…Since the outbreak of the novel coronavirus disease (COVID-19), over 179.7 million people have been infected by SARS-CoV-2 in over 210 countries [1]. This includes developing regions that are endemic for dengue fever, particularly Latin America and Southeast Asia, which raised concern about the effects of co-infection with dengue viruses (DENV) and SARS-CoV-2 [2][3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

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SARS-CoV-2/DENV co-infection: a series of cases from the Federal District, Midwestern Brazil

et al. 2021

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Background Since the novel coronavirus disease outbreak, over 179.7 million people have been infected by SARS-CoV-2 worldwide, including the population living in dengue-endemic regions, particularly Latin America and Southeast Asia, raising concern about the impact of possible co-infections. Methods Thirteen SARS-CoV-2/DENV co-infection cases reported in Midwestern Brazil between April and September of 2020 are described. Information was gathered from hospital medical records regarding the most relevant clinical and laboratory findings, diagnostic process, therapeutic interventions, together with clinician-assessed outcomes and follow-up. Results Of the 13 cases, seven patients presented Acute Undifferentiated Febrile Syndrome and six had pre-existing co-morbidities, such as diabetes, hypertension and hypopituitarism. Two patients were pregnant. The most common symptoms and clinical signs reported at first evaluation were myalgia, fever and dyspnea. In six cases, the initial diagnosis was dengue fever, which delayed the diagnosis of concomitant infections. The most frequently applied therapeutic interventions were antibiotics and analgesics. In total, four patients were hospitalized. None of them were transferred to the intensive care unit or died. Clinical improvement was verified in all patients after a maximum of 21 days. Conclusions The cases reported here highlight the challenges in differential diagnosis and the importance of considering concomitant infections, especially to improve clinical management and possible prevention measures. Failure to consider a SARS-CoV-2/DENV co-infection may impact both individual and community levels, especially in endemic areas.

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“…In Pakistan, the first case was reported in 1985and 52 485 cases including 91 deaths were reported in 2019 out of which the majority 41 of the deaths were from Sindh 3,4 . In recent times, National Institute of Health (NIH) issued a "high alert" in Pakistan as the monsoon season is considered as a period of high risk for the spread of dengue 5 . The spectrum of Dengue ranges from flu like illness to severe dengue with intense signs and symptoms of plasma leak progressing to shock, which contains a high threat of morbidity and mortality 3 .…”

Section: Introductionmentioning

confidence: 99%

Altered Electrolyte Homeostasis and the Severity of Dengue in Children

2021

PJMD

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Background: Dengue is the commonest arboviral disease that is endemic in our country. Electrolyte imbalance is commonly encountered in this disease. There had been only a few worldwide research studies investigating at all the metabolic parameters of dengue infection. Therefore, the study aimed to assess the electrolyte imbalance and its correlation with the severity of dengue fever in pediatrics. Methods:This cross-sectional study was carried out in the Pediatric Department of Ziauddin Hospital over 18 months. Diagnosed patients through detection of Dengue NS1 antigen or serology of dengue fever from 6 months to 18 years of age were enrolled and their history, hematological and electrolyte values (sodium, potassium, calcium, magnesium, and phosphate) were analyzed. Data was analyzed by SPSS and a Chi-squared test was used to compare the frequency of electrolyte disturbances between patients. A p-value <0.05 was considered statistically significant.Results: A higher incidence of dengue fever was observed in the younger age group (81)54 %. The majority of the patients showed mild hyponatremia 82(54.6%), mild hypokalemia 63(42%) and hypocalcemia 96(64 %). Hypophosphatemia 98(65.3 %) (p-value 0.045) was found more compared to hypomagnesemia 22(14.6%). Fever was observed in 100% of patients along with body aches 90(60%), drowsiness 31(20.7%) and abdominal pain 16(10.7%). We also found leucopenia 48(32%) and thrombocytopenia 127(84.6%), whereas hematocrit 30(20 %) was also raised. Conclusion:Majority of electrolytes (sodium, potassium, calcium and phosphate) were found decreased in dengue patients. However, hyponatremia (p=0.001) and hypophosphatemia (p=0.045) were significantly associated to the severity of dengue.

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Dengue fever and COVID‐19 coinfection; a threat to public health for coepidemic in Pakistan

Cited by 19 publications

References 8 publications

Clinical and biochemical parameters of COVID-19 patients with prior or active dengue fever

Clinical and biochemical parameters of COVID-19 patients with prior or active dengue fever

SARS-CoV-2/DENV co-infection: a series of cases from the Federal District, Midwestern Brazil

Altered Electrolyte Homeostasis and the Severity of Dengue in Children

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