Clinical and biochemical parameters of COVID-19 patients with prior or active dengue fever

Teotônio, Isabella Márcia Soares Nogueira; Carvalho, Juliana Lott; Castro, Luiz Cláudio; Nitz, Nadjar; Hagström, Luciana; Rios, Geraldo Gonçalves; Oliveira, Maria de Fátima Rodrigues de; Dallago, Bruno Stéfano Lima; Hecht, Markus

doi:10.1016/j.actatropica.2020.105782

Cited by 33 publications

(35 citation statements)

References 27 publications

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“…139,142 Symptoms such as reduced lymphocyte and monocyte counts, elevated glucose levels, and serious respiratory disorders have been reported in cases with SARS-CoV and DENV coinfection. 143 In the absence of any major clinical symptoms in dormant DENV infection, serious clinical manifestations and a need for hospitalization have been confirmed during the active phase of DENV infection. 143 In cases with no history of DENV-related symptoms, coinfection with SARS-CoV-2 might result in the exacerbation of respiratory complications, mandating hospitalization.…”

Section: Coinfection With Hepatitis B Virus (Hbv) and Sars-cov-2mentioning

confidence: 99%

Viral coinfections in COVID‐19

Aghbash

Eslami

Shirvaliloo

et al. 2021

Journal of Medical Virology

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The most consequential challenge raised by coinfection is perhaps the inappropriate generation of recombinant viruses through the exchange of genetic material among different strains. These genetically similar viruses can interfere with the replication process of each other and even compete for the metabolites required for the maintenance of the replication cycle. Due to the similarity in clinical symptoms of most viral respiratory tract infections, and their coincidence with COVID‐19, caused by SARS‐CoV‐2, it is recommended to develop a comprehensive diagnostic panel for detection of respiratory and nonrespiratory viruses through the evaluation of patient samples. Given the resulting changes in blood markers, such as coagulation factors and white blood cell count following virus infection, these markers can be of diagnostic value in the detection of mixed infection in individuals already diagnosed with a certain viral illness. In this review, we seek to investigate the coinfection of SARS‐CoV‐2 with other respiratory and nonrespiratory viruses to provide novel insights into the development of highly sensitive diagnostics and effective treatment modalities.

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Section: Coinfection With Hepatitis B Virus (Hbv) and Sars-cov-2mentioning

confidence: 99%

Viral coinfections in COVID‐19

Aghbash

Eslami

Shirvaliloo

et al. 2021

Journal of Medical Virology

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“…The single-stranded (ss) RNA and enveloped dengue fever viruses (DENV) and related flaviviruses are different to the circulating SARS-CoV-2 virus with respect to their modes of transmission, viral tropism, and molecular determinants of post-entry viral replication [ 3 , 4 ]. Despite the differences in molecular structure and replication, the clinical features of dengue fever and symptomatic COVID-19 exhibit striking similarities, acute flu-like symptoms 4–5 days and 5–7 days, respectively, after viral exposure, and fever, headache, cough, breathing difficulty, muscle ache, nausea and fatigue, and the release of pro-inflammatory cytokines [ 5 , 6 , 7 , 8 , 9 ]. The course of dengue fever and COVID-19 disease is usually mild and self-limiting after supportive care [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…The course of dengue fever and COVID-19 disease is usually mild and self-limiting after supportive care [ 6 ]. In hospitalized intensive care unit (ICU) patients, the viral illness suffering from either disease often leads to life-threatening cardiovascular and organ complications [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Detection of Anti-Nucleocapsid Antibody in COVID-19 Patients in Bangladesh Is not Correlated with Previous Dengue Infection

Lytton¹,

Yeasmin

Ghosh

et al. 2021

Pathogens

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Background: The assessment of antibody responses to severe acute respiratory syndrome coronavirus-2 is potentially confounded by exposures to flaviviruses. The aims of the present research were to determine whether anti-dengue antibodies affect the viral load and the detection of anti-coronavirus nucleocapsid (N)-protein antibodies in coronavirus infectious disease 2019 (COVID-19) in Bangladesh. Methods: Viral RNA was evaluated in swab specimens from 115 COVID-19 patients by real-time reverse transcription polymerase chain reaction (rT-PCR). The anti-N-protein antibodies, anti-dengue virus E-protein antibodies and the dengue non-structural protein-1 were determined in serum from 115 COVID-19 patients, 30 acute dengue fever pre-COVID-19 pandemic and nine normal controls by ELISA. Results: The concentrations of viral RNA in the nasopharyngeal; Ct median (95% CI); 22 (21.9–23.3) was significantly higher than viral RNA concentrations in oropharyngeal swabs; and 29 (27–30.5) p < 0.0001. Viral RNA concentrations were not correlated with-dengue IgG levels. The anti-nucleocapsid antibodies were IgA 27% positive and IgG 35% positive at days 1 to 8 post-onset of COVID-19 symptoms versus IgA 0% and IgG 0% in dengue patients, p < 0.0001. The levels of anti- nucleocapsid IgA or IgG versus the levels of anti-dengue IgM or IgG revealed no significant correlations. Conclusions: Viral RNA and anti-nucleocapsid antibodies were detected in COVID-19 patients from dengue-endemic regions of Bangladesh, independently of the dengue IgG levels.

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“…During the disease onset, COVID-19 and dengue, for instance, shared similar clinical and laboratory features, being difficult to distinguish from each other. The initial clinical symptoms (e.g., fever, myalgia, fatigue, chills, and headache) and laboratory parameters (e.g., lymphopenia, leukopenia, thrombocytopenia, and elevated transaminases) can be similar in both illnesses [ 99 ].…”

Section: Overlapping Symptoms and Co-infectionmentioning

confidence: 99%

“…Another hypothesis is that cross-reactivity among DENV and SARS-CoV-2, which may be related to tandem virus infection, can lead to false-positive dengue serology [ 17 , 18 , 98 , 99 , 101 , 102 , 103 , 104 , 105 ]. Both hypotheses are feasible and require more comprehensive cohort studies.…”

Section: Overlapping Symptoms and Co-infectionmentioning

confidence: 99%

COVID-19, Chikungunya, Dengue and Zika Diseases: An Analytical Platform Based on MALDI-TOF MS, IR Spectroscopy and RT-qPCR for Accurate Diagnosis and Accelerate Epidemics Control

2021

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COVID-19 and arboviruses (ARBOD) epidemics co-occurrence is a great concern. In tropical and subtropical regions, ARBOD diseases such as chikungunya, dengue, and Zika are frequent. In both COVID-19 and ARBOD cases, an accurate diagnosis of infected patients is crucial to promote adequate treatment and isolation measures in COVID-19 cases. Overlap of clinical symptoms and laboratory parameters between COVID-19 and ARBOD present themselves as an extra challenge during diagnosis. COVID-19 diagnosis is mainly performed by quantitative reverse polymerase chain reaction (RT-qPCR), while ARBOD diagnosis is performed by serology, detection of antigen or antibody, and molecular diagnosis. In this review, the epidemiologic profile of arboviruses and SARS-CoV-2 is analyzed, and potential risks of symptom overlap is addressed. The implementation of an analytical platform based on infrared (IR) spectroscopy, MALDI-TOF mass spectrometry, and RT-qPCR is discussed as an efficient strategy for a fast, robust, reliable, and cost-effective diagnosis system even during the co-occurrence of virus outbreaks. The spectral data of IR spectroscopy and MALDI-TOF MS obtained from COVID-19 infected and recovered patients can be used to build up an integrated spectral database. This approach can enable us to determine quickly the groups that have been exposed and have recovered from COVID-19 or ARBOD, avoiding misdiagnoses.

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Clinical and biochemical parameters of COVID-19 patients with prior or active dengue fever

Cited by 33 publications

References 27 publications

Viral coinfections in COVID‐19

Viral coinfections in COVID‐19

Detection of Anti-Nucleocapsid Antibody in COVID-19 Patients in Bangladesh Is not Correlated with Previous Dengue Infection

COVID-19, Chikungunya, Dengue and Zika Diseases: An Analytical Platform Based on MALDI-TOF MS, IR Spectroscopy and RT-qPCR for Accurate Diagnosis and Accelerate Epidemics Control

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