Dendritic cells treated with HPV16mE7 in a three-dimensional model promote the secretion of IL-12p70 and IFN-γ

Wang, Yating; Li, Wensheng; Liu, Qinshe; Guan, Xiaoying; Hu, Jun

doi:10.1016/j.yexmp.2011.03.005

Cited by 14 publications

(6 citation statements)

References 18 publications

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“…In patients infected with HIV, one should consider several endocrine aspects (Koch and Pacak, 2001; Ungnapatanin et al, 2012). Another example demonstrating that endocrine organs are under the control of the immune system and vice versa represents research on dendritic cells which are important in initiating the body's immune response and have been used for anticancer vaccination (Jacobs et al, 2010; Morrison et al, 2003; Papewalis et al, 2008; Wang et al, 2011). …”

Section: Discussionmentioning

confidence: 99%

The various faces of autoimmune endocrinopathies: Non-tumoral hypergastrinemia in a patient with lymphocytic colitis and chronic autoimmune gastritis

Melcescu

Hogan²,

Brown³

et al. 2012

Experimental and Molecular Pathology

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Serum gastrin levels exceeding 1000 pg/ml (normal, <100) usually raise the suspicion for a neuroendocrine tumor (NET) that secretes gastrin. Rarely, such elevated gastrin levels are seen in patients with pernicious anemia which most commonly is associated with autoimmune gastritis (AG). AG can occur concomitantly with other autoimmune disorders including lymphocytic colitis (LC). Gastrin stimulates enterochromaffin-like cells which increase histamine secretion. Histamine excess can cause diarrhea as can bacterial overgrowth or LC. We present a 57-year-old woman with diarrhea, sporadic epigastric pain, and bloating. She also had a history of interstitial cystitis and took pentosan polysulfate and cetirizine. She had no history of ulcers, renal impairment or carcinoid syndrome. Fasting serum gastrin was 1846 pg/ml. Esophagoduodenal gastroscopy and biopsies revealed chronic gastritis and a pH of 7 with low stomach acid. Serum gastrin and plasma chromogranin A were suggestive of a gastrinoma or NET. Pernicious anemia was unlikely. Imaging studies did not reveal any tumor. Random colonic biopsy was compatible with LC, possibly explaining her diarrhea, although we also considered excessive histamine from elevated gastrin, bacterial overgrowth, and pentosan polysulfate which can cause diarrhea and be misleading in this setting, pointing to the diagnosis of gastrinoma. At 4 year follow-up in 2012, fasting serum gastrin was 1097 pg/ml and the patient asymptomatic taking only cetirizine for nasal allergies. This case illustrates that diarrhea may be associated with very high serum gastrin levels in the setting of chronic gastritis, LC, and interstitial cystitis (pentosan use), without clear evidence for a gastrinoma or NET. If no history of ulcers or liver metastases is present in such cases, watchful observation rather than an extensive/invasive and costly search for a NET may be justified. Considering the various forms of polyglandular syndrome, this may represent a variant and we here provide an algorithm for working up such patients, while also reviewing literature on the intertwined relationship between the immune and endocrine systems.

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Section: Discussionmentioning

confidence: 99%

The various faces of autoimmune endocrinopathies: Non-tumoral hypergastrinemia in a patient with lymphocytic colitis and chronic autoimmune gastritis

Melcescu

Hogan²,

Brown³

et al. 2012

Experimental and Molecular Pathology

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“…DCs generated from peripheral blood monocytes with IL-4 and granulocyte-macrophage colony-stimulating factor were treated with HPV16 mE7, which showed the significantly increased expression of co-stimulatory molecules CD80 and CD40, and the marked production of IL-12p70 and IFN-γ. This subset of DCs could upregulate E7-specific CD8 + T cell responses in patients with hrHPV-associated cervical cancer (63). HPV16 E7 polypeptide is another DC-based HPV vaccine.…”

Section: Preventive and Therapeutic Hpv Vaccinesmentioning

confidence: 99%

Effect of human papillomavirus infection on the immune system and its role in the course of cervical cancer

et al. 2015

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Abstract. Human papillomavirus (HPV) is widely known as a cause of cervical intraepithelial neoplasia (CIN) and cervical cancer. The mechanisms involved have been studied by numerous studies. The integration of the virus genome into the host cells results in the abnormal regulation of cell cycle control. HPV can also induce immune evasion of the infected cells, which enable the virus to be undetectable for long periods of time. The induction of immunotolerance of the host's immune system by the persistent infection of HPV is one of the most important mechanisms for cervical lesions. The present review elaborates on the roles of several types of immune cells, such as macrophages and natural killer cells, which are classified as innate immune cells, and dendritic cells (DCs), cluster of differentiation (CD)4 + /CD8 + T cells and regulatory T cells, which are classified as adaptive immune cells. HPV infection could effect the differentiation of these immune cells in a unique way, resulting in the host's immune tolerance to the infection. The immune system modifications induced by HPV infection include tumor-associated macrophage differentiation, a compromised cellular immune response, an abnormal imbalance between type 1 T-helper cells (Th1) and Th2 cells, regulatory T cell infiltration, and downregulated DC activation and maturation. To date, numerous types of preventative vaccines have been created to slow down carcinogenesis. Immune response activation-based therapeutic vaccine is becoming more and more attractive for the treatment of HPV-associated diseases.

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“…Vaccines have been shown to protect against HPV infection and the subsequent risk of cervical cancer development (40-42), whereas transplantable tumors have long been used to demonstrate vaccine efficacy in preclinical trials in mice (43). Dendritic cells in a 3D culture model exert a notable effect on the enhancement of the immune response to the HPV16 DNA vaccine and indicate that the dendritic cell-based 3D model is a novel approach to the study of the HPV vaccine (44).…”

Section: Il-10 Exerts a Tumor-promoting Effect In Cervical Cancermentioning

confidence: 99%

The paradox of IL-10-mediated modulation in cervical cancer

Wang

Liu

et al. 2013

Biomedical Reports

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Abstract. Interleukin-10 (IL-10) has opposing effects as an anti-inflammatory (potentially cancer-promoting) and antiangiogenic (potentially cancer-inhibiting) agent. The role of IL-10 in cervical cancer is also dual. Here, we review the IL-10-mediated tumor-promoting effect and tumor-inhibiting effects in cervical cancer, among which, human papilloma virus (HPV), human leukocyte antigen-G (HLA-G) and IL-10 polymorphisms are associated with the development of cervical cancer. IL-10 is also used for the therapy of cervical cancer through enhancing proliferation, expression of immunologically important surface molecules and increasing Th1 cytokine production and cytotoxic potential in HPV-specific CD8 (+) cytotoxic T lymphocytes.

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Dendritic cells treated with HPV16mE7 in a three-dimensional model promote the secretion of IL-12p70 and IFN-γ

Cited by 14 publications

References 18 publications

The various faces of autoimmune endocrinopathies: Non-tumoral hypergastrinemia in a patient with lymphocytic colitis and chronic autoimmune gastritis

The various faces of autoimmune endocrinopathies: Non-tumoral hypergastrinemia in a patient with lymphocytic colitis and chronic autoimmune gastritis

Effect of human papillomavirus infection on the immune system and its role in the course of cervical cancer

The paradox of IL-10-mediated modulation in cervical cancer

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