The paradox of IL-10-mediated modulation in cervical cancer

Wang, Yan; Liu, Xiaohong; Li, Yuehong; Ou, Li

doi:10.3892/br.2013.69

Cited by 39 publications

(31 citation statements)

References 55 publications

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“…24 IL-10 is a multifunctional cytokine, exhibiting anti-angiogenic and immunosuppressive properties. 25 In melanoma, it was demonstrate that IL-10 shows an anti-tumor effect via inhibition of angiogenesis. 26 TNF-a, a key cytokine involved in inflammation and immunity, can promote tumorigenesis by facilitating tumor proliferation and metastasis.…”

Section: Discussionmentioning

confidence: 98%

Lipopolysaccharide-induced toll-like receptor 4 signaling in esophageal squamous cell carcinoma promotes tumor proliferation and regulates inflammatory cytokines expression

Wei

Deng

et al. 2016

Diseases of the Esophagus

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Emerging evidence suggests toll-like receptor 4 (TLR4) signaling contributes to cancer development and progression. However, the consequences of signaling via the TLR4 pathway in esophageal squamous cell carcinoma (ESCC) are still unclear. Here, we investigated the impact of Lipopolysaccharide (LPS)-induced TLR4 signaling on ESCC cell proliferation, inflammatory cytokines expression, and downstream molecular mechanisms. Seventy-eight ESCC and 26 normal esophageal specimens were analyzed by immunohistochemistry, and two cell lines (Eca-109 and TE-1) were used for in vitro studies. LPS, a natural agonist of TLR4, was used to activate TLR4 signaling. The effects of LPS-TLR4 signaling on cell proliferation and inflammatory cytokines regulation were examined. Specific inhibitors of mitogen-activated protein kinase (MAPK) (extracellular regulated protein kinase [ERK] and p38) signaling pathways were used to investigate the role of each pathway in LPS-TLR4 signaling. TLR4 protein was increased in ESCC tumor tissues compared with the adjacent normal tissues. TLR4 over-expression was significantly correlated with tumor differentiation grade, lymph node metastasis, and UICC stage. LPS-induced activation of TLR4 signaling promoted cancer cell proliferation, increased production of proinflammatory or immunosuppressive cytokines TNF-α, TGF-β and inhibited the anti-inflammatory cytokine IL-10. LPS-TLR4 signaling was associated with the activation of ERK and p38 MAPK signaling pathways. Further inactivation of the two pathways by specific inhibitors attenuated cell proliferation and inflammatory cytokines expression induced by LPS. Our results indicate that LPS-TLR4 signaling in cancer cells contributes to the progression of human ESCC.

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Section: Discussionmentioning

confidence: 98%

Lipopolysaccharide-induced toll-like receptor 4 signaling in esophageal squamous cell carcinoma promotes tumor proliferation and regulates inflammatory cytokines expression

Wei

Deng

et al. 2016

Diseases of the Esophagus

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“…(B) TC-1 cells (10 5 cells/animal) were injected in IL-10 Ϫ/Ϫ mice and control C57BL/6 mice (WT). Concerning cervical cancer, most research groups obtained results that indicate that IL-10 plays a role in suppression of anti-HPV responses, therefore, facilitating tumor growth [47]. Results are the average tumor volume for four mice in each experimental group.…”

Section: Discussionmentioning

confidence: 99%

“…In fact, IL-10 promoter polymorphism Ϫ819C/T, which leads to higher IL-10 expression [45], represents an increased risk to cervical cancer development [46]. Concerning cervical cancer, most research groups obtained results that indicate that IL-10 plays a role in suppression of anti-HPV responses, therefore, facilitating tumor growth [47]. Indeed, our data show that IL-10 is one of the factors inhibiting NF-B, although based on our experiments, we could not identify the exact molecular mechanism underlying this inhibition.…”

Section: Discussionmentioning

confidence: 99%

HPV16-associated tumors control myeloid cell homeostasis in lymphoid organs, generating a suppressor environment for T cells

Stone

Rossetti

Bolpetti

et al. 2014

Journal of Leukocyte Biology

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Tumors are complex structures containing different types of cells and molecules. The importance of the tumor microenvironment in tumor progression, growth, and maintenance is well-established. However, tumor effects are not restricted to the tumor microenvironment. Molecules secreted by, as well as cells that migrate from tumors, may circulate and reach other tissues. This may cause a series of systemic effects, including modulation of immune responses, and in some cases, leukocytosis and metastasis promotion. Leukocytosis has been described as a poor prognostic factor in patients with cervical cancer. The main etiological factor for cervical cancer development is persistent infection with high oncogenic risk HPV. Our laboratory has been exploring the effects of high oncogenic risk, HPV-associated tumors on lymphoid organs of the host. In the present study, we observed an increase in myeloid cell proliferation and alteration in cell signaling in APCs in the spleen of tumor-bearing mice. In parallel, we characterized the cytokines secreted in the inflammatory and tumor cell compartments in the tumor microenvironment and in the spleen of tumor-bearing mice. We show evidence of constitutive activation of the IL-6/STAT3 signaling pathway in the tumor, including TAMs, and in APCs in the spleen. We also observed that IL-10 is a central molecule in the tolerance toward tumor antigens through control of NF-κB activation, costimulatory molecule expression, and T cell proliferation. These systemic effects over myeloid cells are robust and likely an important problem to be addressed when considering strategies to improve anti-tumor T cell responses.

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“…ИЛ-10 относится к группе противовоспалительных цитокинов и основная функция ИЛ-10 состоит в угнетении синтеза цитокинов Th1-клетками и в снижении активности макрофагов, в том числе продукции провоспалительных цитокинов. Также полагают, что ИЛ-10 способствует стимуляции опухолевого роста в результате ингибирования T-клеточного иммунного ответа [17,19].. ФНО-α усиливает синтез других цитокинов и экспрессию молекул адгезии. Повышение концентрации ФНО-ɑ приводит снижению противоопухолевого эффекта и повышению резистентности организма против развития опухолевого процесса [8].…”

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Study of Informative Value and Prognostic Significance of Some Cytokines and Antimicrobial Peptides for Early Detection of Metastases in Patients With Cervical Cancer.

Safarova¹,

Kaziev²,

Jafarova³

et al. 2018

Theoretical & Applied Science

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The paradox of IL-10-mediated modulation in cervical cancer

Cited by 39 publications

References 55 publications

Lipopolysaccharide-induced toll-like receptor 4 signaling in esophageal squamous cell carcinoma promotes tumor proliferation and regulates inflammatory cytokines expression

Lipopolysaccharide-induced toll-like receptor 4 signaling in esophageal squamous cell carcinoma promotes tumor proliferation and regulates inflammatory cytokines expression

HPV16-associated tumors control myeloid cell homeostasis in lymphoid organs, generating a suppressor environment for T cells

Study of Informative Value and Prognostic Significance of Some Cytokines and Antimicrobial Peptides for Early Detection of Metastases in Patients With Cervical Cancer.

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