Dendritic cell activation by polysaccharide isolated from Angelica dahurica

Kim, Hyungsook; Shin, Bo Ram; Lee, Hong Kyung; Park, Yun Soo; Liu, Qing; Kim, Sung Yeon; Lee, Mi Kyeong; Hong, Jin Tae; Kim, Youngsoo; Han, Sang‐Bae

doi:10.1016/j.fct.2012.12.007

Cited by 37 publications

(18 citation statements)

References 44 publications

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“…In addition, the ethanolic extract of A. dahurica displayed anti-inflammatory effects by the upregulation of heme oxygenase-1, particularly in mice with asthma (21,22). Phytochemical investigations have revealed that there were coumarins (23,24) in A. dahurica as well as lignans (25), polyacetylene (26) and polysaccharides (15). The aim of the present study was to search bioactive phytochemicals for the treatment of allergic inflammatory diseases.…”

Section: Introductionmentioning

confidence: 93%

“…In Traditional Chinese Medicine, the roots of A. dahurica have been used to treat headache, rhinitis, cold and toothache amongst others. Furthermore, pharmacological studies have shown that it has antimicrobial (11), hepatoprotective (12), antioxidative (13) and cholinesterase inhibitory activities (14), and activates dendritic cells (15) and the actions of lipolytic hormones (16). Furthermore, it inhibits the production of prostaglandin E 2 (17) and nitric oxide (NO) (18,19), and reduces the release of histamine (20).…”

Section: Introductionmentioning

confidence: 99%

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Coumarins from the roots of Angelica dahurica cause anti-allergic inflammation

Liu

2017

Experimental and Therapeutic Medicine

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Abstract. Allergic inflammation is induced by allergens and leads to various allergic diseases, including rhinitis, asthma and conjunctivitis. Histamine is important in the pathogenesis of an immunoglobulin E-dependent allergic reaction and results in the secretion of cytokines associated with inflammation. Angelica dahurica (A. dahurica) is a medicinal plant widely used in China for the treatment of symptoms related to allergic inflammation. The present study investigated the chemical constituents from A. dahurica and evaluated their reductive effect on allergic inflammation. As a result, 15 compounds including 13 coumarins have been identified as isoimperatorin (1), imperatorin (2), oxypeucedanin (3), oxypeucedanin hydrate (4), bergapten (5), byakangelicin (6), phellopterin (7), byakangelicol (8), isopimpinellin (9), xanthotoxol (10), xanthotoxin (11), pimpinellin (12), scopoletin (13), β-sitosterol (14) and daucosterol (15). Compounds 1-13 were able to reduce the release of histamine, with compounds 4-6 exhibiting the most potent activity. Furthermore, compounds 1-12 were able to inhibit the secretion of tumor necrosis factor-α, interleukin (IL)-1β and IL-4, with compounds 5 and 7 exhibiting the strongest inhibitory effects. These compounds implemented the inhibitory effects on the expression of inflammatory cytokine genes through the inhibition of nuclear factor-κB activation. Virtual screening by a docking program indicated that compound 3 is a potent histamine H 1 receptor antagonist. Additionally, the calculated physicochemical properties of these compounds support most furanocoumarins to be delivered to binding sites and permeate the cell membrane. The present findings contribute to understanding how A. dahurica attenuates allergic inflammation.

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Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Coumarins from the roots of Angelica dahurica cause anti-allergic inflammation

Liu

2017

Experimental and Therapeutic Medicine

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“…The most widely studied family of PRRs on DCs is Toll-like receptors. In particular, TLR-4 expressed on the surface of DCs was demonstrated to be one to recognize polysaccharides [37,38]. DCs in intestinal mucosa tissue were found to be able to open the tight junctions between epithelial cells without breaking the integrity of the epithelial barrier [39], which provides a probable route for the polysaccharide to interact with DCs.…”

Section: Discussionmentioning

confidence: 99%

Acetylation Modification Improves Immunoregulatory Effect of Polysaccharide from Seeds of Plantago asiatica L.

Jiang

Nie

Huang

et al. 2018

Journal of Chemistry

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The current study was conducted to investigate effects of acetylated Plantago asiatica L. polysaccharides (Ac-PLCPs) on their immunoregulatory activities in bone-marrow-derived dendritic cells (DCs) model. Influences of natural Plantago asiatica L. crude polysaccharide (PLCP) and Ac-PLCPs on inducing phenotypic and functional maturation on DCs were determined. The results showed that Ac-PLCPs with degree of substitution (DS) from 0.06 to 0.1 could not only stimulate the expression of surface molecules major histocompatibility complex class II (MHC II), cluster of differentiation 86 (CD86), and CD80 on DCs ( < 0.01) but also increase the secretion of cytokine IL-12p70 ( < 0.01). The endocytosis activity of DCs was attenuated by Ac-PLCPs treatment ( < 0.01), while the mRNA expressions of chemokine receptors CCR7 and CXCR4 in DCs were significantly increased ( < 0.01). Besides, DCs treated with the Ac-PLCPs showed extremely strong T cell proliferation stimulating activity ( < 0.01). These data showed that Ac-PLCPs had higher maturation-stimulating activity on DCs than PLCP, which indicated that acetylation modification improved the immunoregulatory effect of PLCP.

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“…Its active compounds are coumarin, essential oil, phellopterin, isoimperatorin, imperatorin, oxypeucedanin, byakangelicin and pimpinellin, having been reported to have anti-inflammatory, anti-mutagenic, antimicrobial, anti-tumor, anti-oxidant activities and analgesic effects [9]. Moreover, imperatorin can be used as a lead compound for anti-inflammatory drugs [10].…”

Section: Pharmacological Studiesmentioning

confidence: 99%

“…Moreover, imperatorin can be used as a lead compound for anti-inflammatory drugs [10]. Recently, it has also reported that the polysaccharides isolated from the roots of A. dahurica have the ability of enhancing the proliferation of rat skin cells, acting with anti-oxidant and anti-inflammatory properties [9,11].…”

Section: Pharmacological Studiesmentioning

confidence: 99%

Angelica dahurica (Fish. ex Hoffm.) Benth. et Hook. f. 白芷 (Baizhi, Chinese Angelica)

2015

Dietary Chinese Herbs

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Dendritic cell activation by polysaccharide isolated from Angelica dahurica

Cited by 37 publications

References 44 publications

Coumarins from the roots of Angelica dahurica cause anti-allergic inflammation

Coumarins from the roots of Angelica dahurica cause anti-allergic inflammation

Acetylation Modification Improves Immunoregulatory Effect of Polysaccharide from Seeds of Plantago asiatica L.

Angelica dahurica (Fish. ex Hoffm.) Benth. et Hook. f. 白芷 (Baizhi, Chinese Angelica)

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