Coumarins from the roots of Angelica dahurica cause anti-allergic inflammation

Abstract

Abstract. Allergic inflammation is induced by allergens and leads to various allergic diseases, including rhinitis, asthma and conjunctivitis. Histamine is important in the pathogenesis of an immunoglobulin E-dependent allergic reaction and results in the secretion of cytokines associated with inflammation. Angelica dahurica (A. dahurica) is a medicinal plant widely used in China for the treatment of symptoms related to allergic inflammation. The present study investigated the chemical constituents from A. dahurica and evaluated their reductive effect on allergic inflammation. As a result, 15 compounds including 13 coumarins have been identified as isoimperatorin (1), imperatorin (2), oxypeucedanin (3), oxypeucedanin hydrate (4), bergapten (5), byakangelicin (6), phellopterin (7), byakangelicol (8), isopimpinellin (9), xanthotoxol (10), xanthotoxin (11), pimpinellin (12), scopoletin (13), β-sitosterol (14) and daucosterol (15). Compounds 1-13 were able to reduce the release of histamine, with compounds 4-6 exhibiting the most potent activity. Furthermore, compounds 1-12 were able to inhibit the secretion of tumor necrosis factor-α, interleukin (IL)-1β and IL-4, with compounds 5 and 7 exhibiting the strongest inhibitory effects. These compounds implemented the inhibitory effects on the expression of inflammatory cytokine genes through the inhibition of nuclear factor-κB activation. Virtual screening by a docking program indicated that compound 3 is a potent histamine H 1 receptor antagonist. Additionally, the calculated physicochemical properties of these compounds support most furanocoumarins to be delivered to binding sites and permeate the cell membrane. The present findings contribute to understanding how A. dahurica attenuates allergic inflammation.

Acupoint application inhibits nerve growth factor and attenuates allergic inflammation in allergic rhinitis model rats

“…White mustard seed has antiinflammatory effect [40]. Angelica dahurica has antiinflammatory effect by inhibiting mast cell degranulation and histamine release [41]. Asarum has anti-immune and anti-allergic effects.…”

Systems Pharmacological Approach to Investigate the Mechanism of Acori Tatarinowii Rhizoma for Alzheimer’s Disease

“…β -Gurjunene (M15; DL=0.10, BBB=2.07, and OB=51.36) was experimentally identified with antioxidation activity and antimicrobial activity [ 60 ]. Isopimpinellin (M26; DL=0.17, BBB=0.5, and OB=25.93) was reported to exhibit antiallergic inflammation [ 61 ]. α -Longipinene (M3; DL=0.12, BBB=2.05, and OB=57.47) was reported to inhibit biofilm formation and hyphal growth in Candida albicans [ 62 ].…”

Isoimperatorin reduces the effective dose of dexamethasone in a murine model of asthma by inhibiting mast cell activation

“…Radix Angelica dahurica (family, Apiaceae) is a perennial herb that is abundant in Asia and has antioxidant (Zheng, Shen, Wang, Lu, & Ho, 2016), antimicrobial (Yang et al, 2017), and anti‐allergic effects (Li & Wu, 2017). Furthermore, this herb exhibits anti‐asthmatic effects via the upregulation of heme oxygenase‐1 (M. Y. Lee et al, 2011).…”