Dendrimers in Drug Delivery, Diagnosis and Therapy: Basics and Potential Applications

Prajapati, Sunil Kumar; Maurya, Sandip; Das, Manas; Tilak, Vijay Kumar; Verma, Krishna K.; Dhakar, Ram Chand

doi:10.22270/jddt.v6i1.1190

Cited by 26 publications

(22 citation statements)

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“…Ionic interactions, hydrogen bonding, and hydrophobic interactions are the mechanisms by which dendrimers exert their solubility enhancement. Therefore, dendrimers are capable of improving the solubility, biodistribution, and efficacy of a number of therapeutic agents as well as being used as diagnostic and imaging molecules in animal models bearing brain tumors [65].…”

Section: Higher Solubilization Potentialmentioning

confidence: 99%

Dendrimers as Pharmaceutical Excipients: Synthesis, Properties, Toxicity and Biomedical Applications

2019

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The European Medicines Agency (EMA) and the Current Good Manufacturing Practices (cGMP) in the United States of America, define excipient as the constituents of the pharmaceutical form other than the active ingredient, i.e., any component that is intended to furnish pharmacological activity. Although dendrimers do not have a pharmacopoeia monograph and, therefore, cannot be recognized as a pharmaceutical excipient, these nanostructures have received enormous attention from researchers. Due to their unique properties, like the nanoscale uniform size, a high degree of branching, polyvalency, aqueous solubility, internal cavities, and biocompatibility, dendrimers are ideal as active excipients, enhancing the solubility of poorly water-soluble drugs. The fact that the dendrimer’s properties are controllable during their synthesis render them promising agents for drug-delivery applications in several pharmaceutical formulations. Additionally, dendrimers can be used for reducing the drug toxicity and for the enhancement of the drug efficacy. This review aims to discuss the properties that turn dendrimers into pharmaceutical excipients and their potential applications in the pharmaceutical and biomedical fields.

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Section: Higher Solubilization Potentialmentioning

confidence: 99%

Dendrimers as Pharmaceutical Excipients: Synthesis, Properties, Toxicity and Biomedical Applications

2019

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“…The viscosity of the final product should be optimized so that the dosage form does not run out of the eye. Dendrimers provide solutions to some complex delivery problems for ocular drug delivery 37 .…”

Section: Dendrimersmentioning

confidence: 99%

A Novel Approaches on Ocular Drug Delivery System

Ramesh

Kothapalli

Reddigari

2017

J. Drug Delivery Ther.

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The purpose of this review is giving a current update of the knowledge in this field of ocular drug delivery. The ocular drug delivery has been a major challenge to drug delivery scientists mainly due to its unique anatomy and physiology. One of the major problems encountered by the conventional ocular dosage forms include the rapid precorneal drug loss due to its nasolacrimal drainage, tear turnover and drug dilution resulting in poor bioavailability. These efforts lead to development of novel drug delivery dosage forms such as nanoparticles, liposome, ocuserts, and mucoadhesive formulations. Controlled drug delivery systems offer many advantages over conventional dosage forms in terms of improving drug bioavailability, reducing toxicity and decreasing dosage frequency. Designing noninvasive sustained drug delivery systems and exploring the feasibility of topical application to deliver drugs to the posterior segment may drastically improve drug delivery in the years to come.

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“…Further, evolution of better technologies for delivering drug molecules, safe penetration enhancers and the use of vesicular carriers have rejuvenated the interest for designing TDD system for drugs that were thought to be unfit for trans dermal delivery. 14,15,16,17  Enhanced permeation of drug through skin for transdermal drug delivery.  It contains non-toxic row material in formulation.…”

Section: Need For Transdermal Drug Delivery-mentioning

confidence: 99%

“… The main advantage of ethosomes over liposomes is the increased permeation of the drug. 17,20 Ethosome are vesicular carrier composed of hydroalcohalic orhydrolglycolic phospholipids, in which the concentration of water and alcohol is high. The high concentration of ethanol makes the ethosome unique.…”

Section: Disadvantage Of Ethosome Drug Delivey-mentioning

confidence: 99%

ETHOSOME: A NEW TECHNOLOGY USED AS TOPICAL & TRANSDERMAL DELIVERY SYSTEM

Jaiswal¹,

Kesharwani²,

Kesharwani³

et al. 2016

J. Drug Delivery Ther.

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Transdermal drug delivery system was first introduced more than 20 years ago. Transdermal drug delivery system is a type of convenient drug delivery system where drug goes to the systemic circulation through the protective barrier i.e. Skin is the main target of topical and transdermal preparations. Major aim of transdermal drug delivery system is to cross the stratum corneum. Various methods have been tried to increase the permeation rate of drugs temporarily. Vesicular system is one of the most controversial methods for transdermal delivery of active substances in that ethosome are the ethanolic phospholipids vesicles which are used mainly for transdermal delivery of drugs. Ethosomes are soft, malleable vesicles tailored for enhanced delivery of active agents. Ethosomes have higher penetration rate through the skin. The increased permeation of ethosomes is probably due to its ethanolic content. Ethanol increases the cell membrane lipid fluidity which results in increased skin penetrability of the ethosomes. These ethosomes permeates inside the skin and fuse with cell membrane lipids and release the drug. Hot and cold methods are used for formulation of ethosomes. Evaluation parameters include size, shape, drug content, zeta potential etc. Ethosomes have been successfully evaluated for the delivery of many drugs for e.g. Cyclosporine A, insulin, salbutamol, trihexyphenidil, etc. Ethosomes provides a number of important benefits including improving the drug's efficacy, enhancing patient compliance and comfort and reducing the total cost of treatment. Ethosomes can be important drug delivery tool in the future.

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Dendrimers in Drug Delivery, Diagnosis and Therapy: Basics and Potential Applications

Cited by 26 publications

References 0 publications

Dendrimers as Pharmaceutical Excipients: Synthesis, Properties, Toxicity and Biomedical Applications

Dendrimers as Pharmaceutical Excipients: Synthesis, Properties, Toxicity and Biomedical Applications

A Novel Approaches on Ocular Drug Delivery System

ETHOSOME: A NEW TECHNOLOGY USED AS TOPICAL & TRANSDERMAL DELIVERY SYSTEM

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