Dendrimers for diagnostic applications

Bharti, Divya; Gupta, Nitin; Pooja, Deep; Kulhari, Hitesh

doi:10.1016/b978-0-12-814527-2.00013-5

Cited by 9 publications

(6 citation statements)

References 146 publications

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“…The development of new and improved contrast agents for computed tomography (CT) has proven to be necessary due to the lack of targeted specificity, the renal toxicity at high doses and the rapid clearing from the blood stream of the iodine-based compounds that are currently used in clinical applications. Thus, the development of contrast agents with longer blood stream circulation time, lower renal toxicity, higher contrast quality and high specificity was considered a challenge [ 236 , 237 ].…”

Section: Biomedical Applications Of Dendrimersmentioning

confidence: 99%

“…To improve the stability and targeting of iodine-based compounds, 131 I-PAMAM dendrimers were developed [ 236 ]. Due to the higher X-ray attenuation coefficient than that of iodine-based compounds, bismuth sulfide and gold nanoparticles were investigated.…”

Section: Biomedical Applications Of Dendrimersmentioning

confidence: 99%

“…Gold nanoparticles were entrapped by dendrimers, such as the G5-PAMAM dendrimers that provided a good X-ray attenuation, the acetylated PAMAM dendrimers that targeted lung adenocarcinoma and increased biocompatibility, the folic acid-G2 PAMAM dendrimers that targeted mouth carcinoma and provided good cytocompatibility and a high X-ray attenuation, and the lactobionic acid-PAMAM dendrimers that targeted hepatic cancer and provided high X-ray attenuation [ 236 ].…”

Section: Biomedical Applications Of Dendrimersmentioning

confidence: 99%

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Applications and Limitations of Dendrimers in Biomedicine

et al. 2020

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Biomedicine represents one of the main study areas for dendrimers, which have proven to be valuable both in diagnostics and therapy, due to their capacity for improving solubility, absorption, bioavailability and targeted distribution. Molecular cytotoxicity constitutes a limiting characteristic, especially for cationic and higher-generation dendrimers. Antineoplastic research of dendrimers has been widely developed, and several types of poly(amidoamine) and poly(propylene imine) dendrimer complexes with doxorubicin, paclitaxel, imatinib, sunitinib, cisplatin, melphalan and methotrexate have shown an improvement in comparison with the drug molecule alone. The anti-inflammatory therapy focused on dendrimer complexes of ibuprofen, indomethacin, piroxicam, ketoprofen and diflunisal. In the context of the development of antibiotic-resistant bacterial strains, dendrimer complexes of fluoroquinolones, macrolides, beta-lactamines and aminoglycosides have shown promising effects. Regarding antiviral therapy, studies have been performed to develop dendrimer conjugates with tenofovir, maraviroc, zidovudine, oseltamivir and acyclovir, among others. Furthermore, cardiovascular therapy has strongly addressed dendrimers. Employed in imaging diagnostics, dendrimers reduce the dosage required to obtain images, thus improving the efficiency of radioisotopes. Dendrimers are macromolecular structures with multiple advantages that can suffer modifications depending on the chemical nature of the drug that has to be transported. The results obtained so far encourage the pursuit of new studies.

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Section: Biomedical Applications Of Dendrimersmentioning

confidence: 99%

Section: Biomedical Applications Of Dendrimersmentioning

confidence: 99%

Section: Biomedical Applications Of Dendrimersmentioning

confidence: 99%

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Applications and Limitations of Dendrimers in Biomedicine

et al. 2020

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“…For instance, FITC or rhodamine dyes were encapsulated in functionalized (lauroyl and propranolol) PAMAM dendrimers and used for detection of colon and breast cancers [ 63 , 64 ]. Other examples and techniques have been reviewed [ 39 , 65 ].…”

Section: Dendrimers General Role In Cancermentioning

confidence: 99%

A Glimpse into Dendrimers Integration in Cancer Imaging and Theranostics

Cruz

Barbosa

Antunes

et al. 2023

IJMS

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Cancer is a result of abnormal cell proliferation. This pathology is a serious health problem since it is a leading cause of death worldwide. Current anti-cancer therapies rely on surgery, radiation, and chemotherapy. However, these treatments still present major associated problems, namely the absence of specificity. Thus, it is urgent to develop novel therapeutic strategies. Nanoparticles, particularly dendrimers, have been paving their way to the front line of cancer treatment, mostly for drug and gene delivery, diagnosis, and disease monitoring. This is mainly derived from their high versatility, which results from their ability to undergo distinct surface functionalization, leading to improved performance. In recent years, the anticancer and antimetastatic capacities of dendrimers have been discovered, opening new frontiers to dendrimer-based chemotherapeutics. In the present review, we summarize the intrinsic anticancer activity of different dendrimers as well as their use as nanocarriers in cancer diagnostics and treatment.

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“…Another outstanding application is the use of dendritic materials in diagnosis [ 46 ], such as iron oxide magnetic nanoparticles decorated with dendrimers, which can be monitored through magnetic resonance, or the oxygen sensors, very useful in pathologies such as diabetes [ 47 ]. Dendrimers also enable a combined therapeutic and diagnostic action in a single platform, the so-called “theranosis” [ 48 ].…”

Section: Dendrimers: Synthesis Uses and Challenges To Face In Bimentioning

confidence: 99%

Dendrimers and Dendritic Materials: From Laboratory to Medical Practice in Infectious Diseases

et al. 2020

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Infectious diseases are one of the main global public health risks, predominantly caused by viruses, bacteria, fungi, and parasites. The control of infections is founded on three main pillars: prevention, treatment, and diagnosis. However, the appearance of microbial resistance has challenged traditional strategies and demands new approaches. Dendrimers are a type of polymeric nanoparticles whose nanometric size, multivalency, biocompatibility, and structural perfection offer boundless possibilities in multiple biomedical applications. This review provides the reader a general overview about the uses of dendrimers and dendritic materials in the treatment, prevention, and diagnosis of highly prevalent infectious diseases, and their advantages compared to traditional approaches. Examples of dendrimers as antimicrobial agents per se, as nanocarriers of antimicrobial drugs, as well as their uses in gene transfection, in vaccines or as contrast agents in imaging assays are presented. Despite the need to address some challenges in order to be used in the clinic, dendritic materials appear as an innovative tool with a brilliant future ahead in the clinical management of infectious diseases and many other health issues.

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Dendrimers for diagnostic applications

Cited by 9 publications

References 146 publications

Applications and Limitations of Dendrimers in Biomedicine

Applications and Limitations of Dendrimers in Biomedicine

A Glimpse into Dendrimers Integration in Cancer Imaging and Theranostics

Dendrimers and Dendritic Materials: From Laboratory to Medical Practice in Infectious Diseases

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