Dendrimers: A Class of Polymer in the Nanotechnology for Drug Delivery

Singh, Sarita; Sharma, Vivek

doi:10.1002/9781118636299.ch13

Cited by 6 publications

(17 citation statements)

References 104 publications

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“…MRI is a technique used to obtain anatomical images of the internal organs and the vascular tree [ 51 , 92 , 93 ]. The use of contrast agents to obtain these images significantly improves their quality, and the administration of contrast agents can be done using dendrimers [ 1 , 56 , 88 , 94 ]. Contrast agents commonly used in MRI are paramagnetic metal cations of gadolinium, such as Gd(III)-N,N′,N″,N‴-tetracarboxymethyl-1,4,7,10-tetraazacyclododecane (Gd(III)-DOTA) and Gd(III)-diethylenetriamine pentaacetic acid (Gd(III)-DTPA), or other derivatives thereof.…”

Section: The Use Of Dendrimers In Cancer Diagnosismentioning

confidence: 99%

“…However, due to their low molecular weight, these agents can diffuse from blood vessels and have a short circulation time in the body, and differentiated targeting towards diseased and normal tissues is inefficient. This disadvantage can be minimized by attaching gadolinium cations to the surfaces of dendrimers [ 51 , 56 , 63 , 70 , 88 , 95 , 96 ].…”

Section: The Use Of Dendrimers In Cancer Diagnosismentioning

confidence: 99%

“…Dendrimers can be distributed to specific targets via passive or active pathways [ 14 , 56 , 88 , 121 , 122 , 123 ]. The passive pathway is based on the accumulation of PEGylated dendrimers in tumor tissues due to the permeability and retention effects of tumors [ 124 ].…”

Section: Targeting and Treatmentmentioning

confidence: 99%

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Dendrimers: Advancements and Potential Applications in Cancer Diagnosis and Treatment—An Overview

et al. 2023

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Cancer is a leading cause of death worldwide, and the main treatment methods for this condition are surgery, chemotherapy, and radiotherapy. These treatment methods are invasive and can cause severe adverse reactions among organisms, so nanomaterials are increasingly used as structures for anticancer therapies. Dendrimers are a type of nanomaterial with unique properties, and their production can be controlled to obtain compounds with the desired characteristics. These polymeric molecules are used in cancer diagnosis and treatment through the targeted distribution of some pharmacological substances. Dendrimers have the ability to fulfill several objectives in anticancer therapy simultaneously, such as targeting tumor cells so that healthy tissue is not affected, controlling the release of anticancer agents in the tumor microenvironment, and combining anticancer strategies based on the administration of anticancer molecules to potentiate their effect through photothermal therapy or photodynamic therapy. The purpose of this review is to summarize and highlight the possible uses of dendrimers regarding the diagnosis and treatment of oncological conditions.

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Section: The Use Of Dendrimers In Cancer Diagnosismentioning

confidence: 99%

Section: The Use Of Dendrimers In Cancer Diagnosismentioning

confidence: 99%

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Dendrimers: Advancements and Potential Applications in Cancer Diagnosis and Treatment—An Overview

et al. 2023

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“…Dendrimers are regular hyperbranched monodisperse macromolecules with a well-defined spherical structure. These nanosized macromolecules are widely used in biomedicine [ 1 , 2 , 3 , 4 , 5 , 6 ] as carriers in gene and drug delivery [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. In the latter case, dendrimers contribute to an increase in the solubility of drugs, a decrease in their toxicity for normal cells, and a prolongation in their circulation time in blood flow [ 15 , 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

NMR Studies of Two Lysine Based Dendrimers with Insertion of Similar Histidine-Arginine and Arginine-Histidine Spacers Having Different Properties for Application in Drug Delivery

Sheveleva

Tarasenko

Vovk

et al. 2023

IJMS

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In this paper we study two lysine-based peptide dendrimers with Lys-His-Arg and Lys-Arg-His repeating units and terminal lysine groups. Combination of His and Arg properties in a dendrimer could be important for biomedical applications, especially for prevention of dendrimer aggregation and for penetration of dendrimers through various cell membranes. We describe the synthesis of these dendrimers and the confirmation of their structure using 1D and 2D Nuclear Magnetic Resonance (NMR) spectroscopy. NMR spectroscopy and relaxation are used to study the structural and dynamic properties of these macromolecules and to compare them with properties of previously studied dendrimers with Lys-2Arg and Lys-2His repeating units. Our results demonstrate that both Lys-His-Arg and Lys-Arg-His dendrimers have pH sensitive conformation and dynamics. However, properties of Lys-His-Arg at normal pH are more similar to those of the more hydrophobic Lys-2His dendrimer, which has tendency towards aggregation, while the Lys-Arg-His dendrimer is more hydrophilic. Thus, the conformation with the same amino acid composition of Lys-His-Arg is more pH sensitive than Lys-Arg-His, while the presence of Arg groups undoubtedly increases its hydrophilicity compared to Lys-2His. Hence, the Lys-His-Arg dendrimer could be a more suitable (in comparison with Lys-2His and Lys-Arg-His) candidate as a pH sensitive nanocontainer for drug delivery.

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“…The most commonly used types of dendrimer are mentioned in Figure 2 [110, [120][121][122][123][124][125][126][127][128][129][130][131][132][133].…”

Section: Types Of Dendrimersmentioning

confidence: 99%

Nano-based drug delivery system

Eskiler¹,

Dıkmen²,

Genc³

2015

Nano Based Drug Delivery

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Dendrimers: A Class of Polymer in the Nanotechnology for Drug Delivery

Cited by 6 publications

References 104 publications

Dendrimers: Advancements and Potential Applications in Cancer Diagnosis and Treatment—An Overview

Dendrimers: Advancements and Potential Applications in Cancer Diagnosis and Treatment—An Overview

NMR Studies of Two Lysine Based Dendrimers with Insertion of Similar Histidine-Arginine and Arginine-Histidine Spacers Having Different Properties for Application in Drug Delivery

Nano-based drug delivery system

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