Demonstration of CSF gamma‐globulin banding in presenile dementia

Williams, Adrian; Papadopoulos, Nicholas M.; Chase, Thomas N.

doi:10.1212/wnl.30.8.882

Cited by 29 publications

(9 citation statements)

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“…multiple sclerosis [14], have been associated with the presence of oligoclonal bands in CSF using IEF followed by immunofixation. Protein bands, probably representing oligoclonal IgG production, were demonstrated in CSF sam ples from 5 unselected cases with presenile dementia [22]. No such changes could be demonstrated in our material.…”

Section: Discussioncontrasting

confidence: 52%

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Isoelectric Focusing and Two-Dimensional Gel Electrophoresis in Plasma and Cerebrospinal Fluid from Patients with Dementia

Alafuzoff¹,

Adolfsson²,

Bucht

et al. 1986

Eur Neurol

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IgG profiles of cerebrospinal fluid (CSF) and plasma from patients with Alzheimer’s disease/senile dementia of Alzheimer type, multi-infarct dementia and aged nondemented individuals were analyzed using isoelectric focusing (IEF) followed by immunofixation and high resolution two-dimensional polyacrylamide gel electrophoresis (PAGE). The IEF profiles of plasma and CSF in patients with dementia were diffuse and lacked oligoclonal bands and were identical to those of nondemented individuals. The investigation of plasma and CSF by two-dimensional PAGE did not reveal any specific protein pattern in the demented individuals compared to the controls.

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Section: Discussioncontrasting

confidence: 52%

“…No such changes could be demonstrated in our material. Oligoclonal IgG production by plasma cells in CSF might be initiated by an unspecific reaction to the tissue damage found in the late stages of dementia and this may provide an explana tion for the contrasting results reported by other workers in studies on demented pa tients [22].…”

Section: Discussionmentioning

confidence: 85%

Isoelectric Focusing and Two-Dimensional Gel Electrophoresis in Plasma and Cerebrospinal Fluid from Patients with Dementia

Alafuzoff¹,

Adolfsson²,

Bucht

et al. 1986

Eur Neurol

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“…Although the occurrence of CNS specific OCB in the CSF of patients with Alzheimer's disease was first reported in 1980 [16] this and subsequent reports have only evaluated relatively small numbers of patients [1,5,10] [3,4,7,8]. The presence of OCB in primary neurodegenerative dementia is generally considered to be a rarity such that their absence is supportive of diagnosis, specifically for example of probable AD [13].…”

Section: Introductionmentioning

confidence: 99%

The prevalence of oligoclonal bands in the CSF of patients with primary neurodegenerative dementia

Janssen

Godbolt

Ioannidis

et al. 2004

Journal of Neurology

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“…It has been suggested that sub‐populations of AD patients are characterized by oligoclonal bands in CSF, indicating intra‐blood‐brain barrier IgG production. This would support hypotheses concerning the involvement of infectious agents or abnormalities of the immune system in the etiology of AD 115 , 116 . This contention, however, is not supported by results of either conventional electrophoresis, agarose isoelectric focussing, or two‐dimensional polyacrylamide gel electrophoresis, all of which failed to show oligoclonal banding in CSF of AD patients 111 , 117–119 .…”

Section: Amino Acids and Proteinsmentioning

confidence: 71%

Cerebrospinal Fluid Markers of Alzheimer's Disease

Gool

Bolhuis

1991

J American Geriatrics Society

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Objective: To review studies on cerebrospinal fluid (CSF) in patients with Alzheimer's disease (AD) in order to answer the question whether CSF contains a specific marker which can be used to support a clinical diagnosis of AD. Data sources: Studies identified through an English‐language literature search using MEDLINE (1966 to 1990) and a review of bibliographies of relevant articles. Study Selection: All studies on CSF in AD patients were selected. Double publications on the same original data were not included. Otherwise, no particular selection was made. Data Extraction: The diagnostic utility of more than 60 substances, including CSF measures related to classical neurotransmitters, (neuro)peptides, proteins, amino acids, purines, trace elements, and constituents of senile plaques and neurofibrillary tangles, is evaluated. Clinical epidemiological criteria for deciding on the usefulness of new diagnostic methods are emphasized in this analysis. Data Synthesis: Concentrations of some CSF constituents are consistently found to be significantly changed in AD. However, overlap with data of control populations and methodological shortcomings in study design, limit the diagnostic value of all CSF measurements reviewed. Conclusion: None of the CSF constituents studied so far can be used in support of the diagnosis of AD. However, increased knowledge concerning macromolecular abnormalities in amyloid containing plaques and neurofibrillary tangles makes the outlook for a diagnostic test for AD on CSF promising.

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Demonstration of CSF gamma‐globulin banding in presenile dementia

Cited by 29 publications

References 0 publications

Isoelectric Focusing and Two-Dimensional Gel Electrophoresis in Plasma and Cerebrospinal Fluid from Patients with Dementia

Isoelectric Focusing and Two-Dimensional Gel Electrophoresis in Plasma and Cerebrospinal Fluid from Patients with Dementia

The prevalence of oligoclonal bands in the CSF of patients with primary neurodegenerative dementia

Cerebrospinal Fluid Markers of Alzheimer's Disease

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