Demographic characteristics of transfusion-transmitted infections among blood donors in China

Abstract

Background Demographic characteristic surveillance of transfusion-transmitted infections (TTIs) among blood donors is crucial to formulating control strategies and preventing TTIs. This study aimed to investigate the demographic characteristics and social factors associated with TTIs among blood donors from 14 different blood centers or banks in China, covering almost the entire China. Methods Demographic information of 1976 blood donations were obtained from the donor databases of 14 blood centers. The results of the samples were confirmed by the National Center for Clinical Laboratories (NCCL). Results Of the 1976 donations, 928 were confirmed as TTI positive (HBV, 309; HCV, 162; HIV, 116; syphilis, 341), while 1048 tested negative. The differences in demographic distribution of TTI positive and negative donations regarding age, previous donation history, occupation, and education were statistically significant ( p < 0.001). The factors mentioned above and marital status had associations with TTIs. Among the TTIs, only syphilis was related to ethnicity (adjusted odds ratio [aOR]: 2.309, 95% confidence interval [CI]: 1.378–3.868, p = 0.001), and only HBV positivity was not associated with marital status (HBV, aOR: 0.933, 95% CI: 0.670–1.299, p = 0.681). Gender and education were independent predictors of HIV and syphilis infections ( p < 0.05). Conclusions Demographic characteristics in this study included age, gender, previous donation history, ethnicity, marital status, occupation, and education, some of which were associated with TTIs. The most susceptible populations for TTIs were unmarried males and first-time donors aged between 26 and 55 years, and blood donors who were workers or company employees with low-educational level. Timely surveillance and updated demographic data on blood donors are critical for blood safety.

Trends and epidemiological analysis of hepatitis B virus, hepatitis C virus, human immunodeficiency virus, and human T-cell lymphotropic virus among Iranian blood donors: strategies for improving blood safety

“…Furthermore, this study found that the seroprevalence of TTIs decreased with an increase in the education level [9]. These results are in accordance with the findings from other countries including Ethiopia, China, and Turkey [11][12][13]. Another study reported that the seroprevalence of HTLV1 was higher in female, married, and older blood donors [8].…”

Association of transfusion transmitted infections with ABO and Rh D blood group system in healthy blood donors: a retrospective analysis

“…Transfusion Transmitted Infections (TTI) especially hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV) always pose threat to blood transfusion services. 1 National AIDS Control major concern as it is responsible for significant global morbidity and mortality with an estimated more than half a million deaths across the world. 6 It has been shown that ABO blood groups have some connections with a variety of infectious and non-infectious diseases along with susceptibility to some infections.…”

A study based on four immunoassays: Hepatitis C virus antibody against different antigens may have unequal contributions to detection

“…Between November 2012 and December 2017, 682 specimens from voluntary blood donors tested positive for anti-HCV were collected in 22 blood centers/banks from 17 provinces and municipalities including Beijing, Chongqing, Gansu, Hebei, Heilongjiang, Henan, Hubei, Hunan, Inner Mongolia, Jiangsu, Jilin, Liaoning, Ningxia, Shaanxi, Shandong, Shenzhen and Tianjin. These specimens were primary screened with EIA assays mentioned previously [ 20 ] and then transported on dry ice to National Center for Clinical Laboratories (NCCL) in Beijing. Figure 1 demonstrated the flow chart representing the study process.…”